Rchr
J-GLOBAL ID：200901027480766133   Update date: Oct. 17, 2024

Nakata Susumu

ナカタ ススム | Nakata Susumu
Affiliation and department：
Kyoto Pharmaceutical University

About Kyoto Pharmaceutical University


Homepage URL  (1)： http://labo.kyoto-phu.ac.jp/oncology/
Research field  (1)： Tumor biology
Research keywords  (5)： gastrointestinal cancer ,  glioblastoma ,  cancer metabolic reprogramming ,  cancer stem cells ,  cancer research
Research theme for competitive and other funds  (16)：
  • 2024 - 2028 膠芽腫幹細胞の増殖を阻害する新規チオフェンカルボキサミド誘導体の合成研究
  • 2024 - 2027 Elucidation of the Pathological Significance of CD276 Expression in M2 Macrophages in Primary Central Nervous System Lymphoma
  • 2023 - 2027 Construction of pseudo-natural products using enzymes from medicinal plants and development of therapeutic agents for glioblastoma
  • 2023 - 2026 GGCT阻害によるNotch制御機構の解明と膠芽腫幹細胞を標的する新規治療法の確立
  • 2022 - 2025 GGCTとxCTのダブル阻害によりフェロトーシスを増強する全く新しいがん治療戦略
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Papers (65)：
  • Kozue Nose, Keiko Taniguchi, Mitsugu Fujita, Chiami Moyama, Masaya Mori, Mizuki Ishita, Tatsushi Yoshida, Hiromi Ii, Toshiyuki Sakai, Susumu Nakata. γ-Glutamylcyclotransferase is transcriptionally regulated by c-Jun and controls proliferation of glioblastoma stem cells through Notch1 levels. Cancer Gene Therapy. 2024
  • Kaito Ohta, Hiromi Ii, Mei Takahashi, Chiami Moyama, Shota Ando, Masaya Mori, Maho Masuda, Hisanori Nambu, Susumu Nakata, Naoto Kojima. Structure-activity relationships study of N-ethylene glycol-comprising alkyl heterocyclic carboxamides against A549 lung cancer cells. Future medicinal chemistry. 2024. 1-16
  • Tomoya Ueno, Shohei Otani, Yuki Date, Yu Katsuma, Yuma Nagayoshi, Tomoko Ito, Hiromi Ii, Susumu Kageyama, Susumu Nakata, Kosei Ito. Myc upregulates Ggct, γ-glutamylcyclotransferase to promote development of p53-deficient osteosarcoma. Cancer science. 2024
  • Keiichi Ishihara, Ryuto Sakoda, Masako Mizoguchi, Mitsugu Fujita, Chiami Moyama, Yuri Okutani, Kazuyuki Takata, Miwa Tanaka, Takashi Minami, Haruhiko Sago, et al. Suppression of Sleeping Beauty-induced Gliomagenicity in Ts1Cje Mice, a Model of Down Syndrome. Anticancer research. 2024. 44. 2. 489-495
  • Masaya Mori, Hiromi Ii, Mitsugu Fujita, Kozue Nose, Ayako Shimada, Risa Shiraki, Yuhi Sone, Chiami Moyama, Keiko Taniguchi, Susumu Nakata. Desert Hedgehog Down-regulation Mediates Inhibition of Proliferation by γ-Glutamylcyclotransferase Knockdown in Murine Glioblastoma Stem Cells. Cancer genomics & proteomics. 2024. 21. 5. 474-484
ｍore...
MISC (147)：
  • 菰池璃香, 近藤由佳, 立川歩実, 近藤真帆, 伊藤公成, 飯居宏美, 中田晋. Involvement of wnt-β-catenin pathway suppression in anticancer activity of GGCT inhibition in colorectal cancer cells. 日本薬学会年会要旨集(Web). 2024. 144th
  • 齋藤 友充子, 谷口 恵香, 飯居 宏美, 堀中 真野, 影山 進, 中田 晋, 浮村 理, 酒井 敏行. c-Met発現低下を介したγ-glutamylcyclotrasnferase(GGCT)阻害による前立腺がん細胞増殖抑制の新規分子機構の解明(Identification of c-Met as a novel target of gamma-glutamylcyclotrasnferase in a prostate cancer cell line). 日本泌尿器科学会総会. 2023. 110回. AOP09-07
  • 大田海斗, 飯居宏美, 茂山千愛美, 安藤翔太, 岩崎宏樹, 南部寿則, 中田晋, 小島直人. N-トリエチレングリコール含有アルキル-3-カルボキサミドの合成と膠芽腫に対する抗腫瘍効果. 日本薬学会九州山口支部大会講演要旨集(CD-ROM). 2023. 40th
  • 飯居宏美, 近藤真帆, 伊藤公成, 中田晋. Suppression of Wnt pathway is involved in anticancer activity of GGCT knockdown in colorectal cancer cells. 日本癌学会学術総会抄録集(Web). 2023. 82nd
  • 中田晋, 小島直人. Novel AMPK activators inhibiting mitochondrial complex I that attack glioblastoma, and colon/lung cancer. 日本癌学会学術総会抄録集(Web). 2023. 82nd
ｍore...
Patents (2)：
  • NOVEL AMP-ACTIVATED PROTEIN KINASE ACTIVATOR
  • Novel AMPK activators
Books (1)：
  • LGR5 as a marker in brain cancer, Biomarkers in Disease: Methods, Discoveries and Applications
    Springer Netherlands 2015
Education (2)：
  • 2002 - 2006 Kyoto Prefectural University of Medicine Ph D program Medical Science
  • 1992 - 1998 Kyoto Prefectural University of Medicine
Professional career (1)：
  • 博士(医学) (京都府立医科大学)
Work history (8)：
  • 2015/01 - 現在 Kyoto Pharmaceutical University Department of Clinical Oncology Associate Professor
  • 2011/04 - 2014/12 Aichi Cancer Center Research Institute Oncological Pathology Senior Researcher
  • 2010/05 - 2011/03 Yokohama City University Regenerative Medicine Contracted Assistant
  • 2007/11 - 2010/04 German Cancer Research Center Division of Molecular Genetics Guest Scientist
  • 2007/04 - 2007/10 Second Okamoto General Hospital Gastrointestinal Divisions Medical Doctor
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Awards (1)：
  • 2007/11 - Alexander von Humboldt Foundation Fellowship
Association Membership(s) (7)：
日本がん分子標的治療学会 ,  THE PHARMACEUTICAL SOCIETY OF JAPAN ,  THE JAPANESE SOCIETY OF INTERNAL MEDICINE ,  THE JAPANESE SOCIETY FOR HYGIENE ,  JAPAN GASTROENTEROLOGICAL ENDOSCOPY SOCIETY ,  The Japanese Society of Gastroenterology ,  THE JAPANESE CANCER ASSOCIATION
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