Rchr
J-GLOBAL ID:200901027951060880
Update date: May. 24, 2024
Hiraoka Yoshinori
ヒラオカ ヨシノリ | Hiraoka Yoshinori
Affiliation and department:
Job title:
Assistant Professor
Research field (2):
Molecular biology
, Functional biochemistry
Research keywords (3):
多機能メタロペプチダーゼ
, 体内時計
, 体温恒常性
Research theme for competitive and other funds (11):
- 2019 - 2022 A metalloprotease regulates the activity of the nuclear receptor REV-ERBs
- 2016 - 2019 A metalloprotease regulates the circadian clock
- 2013 - 2016 Molecular mechanism and biomarkers for non-alcoholic steatohepatitis
- 2013 - 2015 Assessment of temperature compensation of circadian rhythm by using cold-blooded mice
- 2012 - 2014 個体恒常性を制御する天然変性タンパク質ナルディライジンの機能解明
- 2011 - 2014 Pathophysiological roles of nardilysin, critical factor for axonal maturation and myelination
- 2009 - 2010 The role of M16 family metalloprotease in Alzheimer's disease
- 2008 - 2010 The role of nardilysin in body temperature homeostasis
- 2008 - 2008 体温による生体防御反応の制御機構:変温マウスを用いた解析
- 2007 - 2008 肺細菌感染症における宿主膜タンパク質シェディング誘導の病態生理学的意義の解明
- 2006 - 2007 緑膿菌由来毒力因子による細胞外ドメインのシェディング誘導機構の解明とその臨床応用
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Papers (23):
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Sayaka Saijo, Mikiko Ohno, Hirotaka Iwasaki, Shintaro Matsuda, Kiyoto Nishi, Yoshinori Hiraoka, Natsuki Ide, Takeshi Kimura, Eiichiro Nishi. Nardilysin in adipocytes regulates UCP1 expression and body temperature homeostasis. Scientific reports. 2022. 12. 1. 3449-3449
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Daisuke Yasuda, Yoshinori Hiraoka, Mikiko Ohno, Kiyoto Nishi, Hirotaka Iwasaki, Toru Kita, Eiichiro Nishi, Noriaki Kume. Deficiency of Nardilysin in the Liver Reduces Serum Cholesterol Levels. Biological & pharmaceutical bulletin. 2021. 44. 3. 363-371
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Mikiko Ohno, Kiyoto Nishi, Yoshinori Hiraoka, Shinichiro Niizuma, Shintaro Matsuda, Hirotaka Iwasaki, Takeshi Kimura, Eiichiro Nishi. Nardilysin controls cardiac sympathetic innervation patterning through regulation of p75 neurotrophin receptor. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2020. 34. 9. 11624-11640
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Daisuke Yasuda, Haruki Torii, Rumiko Shimizu, Yoshinori Hiraoka, Noriaki Kume. Reduced Serum Cholesterol and Triglyceride Levels in a Choline-Deficient L-Amino Acid-Defined High-Fat Diet (CDAHFD)-Induced Mouse Model of Non-alcoholic Steatohepatitis (NASH). Biological & pharmaceutical bulletin. 2020. 43. 4. 616-618
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Haruki Torii, Rumiko Shimizu, Yuriko Tanizaki, Yurina Omiya, Miwa Yamamoto, Sayaka Kamiike, Daisuke Yasuda, Yoshinori Hiraoka, Tohru Hashida, Noriaki Kume. Effects of Ramelteon and Other Sleep-Promoting Drugs on Serum Low-Density Lipoprotein and Non-high-density Lipoprotein Cholesterol: A Retrospective Comparative Pilot Study. Biological & pharmaceutical bulletin. 2018. 41. 12. 1778-1790
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MISC (1):
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Mikiko T. Ohno, Yoshinori Hiraoka, Tatsuhiko Matsuoka, Kiyoto Nishi, Sayaka Saijo, Takeshi Kimura, Eiichiro Nishi. Nardilysin Regulates Circulatory Dynamics Through Modulating Sympathetic Nerve Innervation. CIRCULATION. 2011. 124. 21
Education (3):
- 1998 - 2002 東京工業大学大学院 総合理工学研究科 人間環境システム専攻(博士課程)
- 1996 - 1998 東京工業大学大学院 総合理工学研究科 人間環境システム専攻(修士課程)
- 1992 - 1996 Sophia University Faculty of Science and Technology Department of Mechanical Engineering
Professional career (1):
- Doctor of Engineering (Tokyo Institute of Technology)
Work history (7):
- 2023/03 - 現在 Technical University of Munich School of Life Sciences, Metabolic Programming (PI: Prof. Nina Henriette Uhlenhaut) Visiting Researcher
- 2014/04 - 現在 Kobe Gakuin University The Faculty of Pharmaceutical Sciences
- 2013/04 - 2023/03 京都大学大学院 医学研究科 循環器内科学 客員研究員
- 2013/04 - 2014/03 Kobe Gakuin University The Faculty of Pharmaceutical Sciences
- 2007/04 - 2013/03 京都大学大学院医学研究科 循環器内科学 産学官連携助教
- 2004/11 - 2007/03 京都大学大学院医学研究科 先端領域融合医学研究機構 特任助手
- 2002/04 - 2004/10 University of Illinois at Chicago (UIC), College of Medicine Department of Microbiology and Immunology (PI: Prof. Ananda M Chakrabarty) Postdoctoral Fellow
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Committee career (1):
Awards (1):
- 2019/08 - XVI Congress of the European Biological Rhythms Society (EBRS) Poster Award
Association Membership(s) (4):
日本分子生物学会
, 日本時間生物学会
, 日本薬学会
, The American Society for Cell Biology (ASCB)
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