2020 - 2023 Development of the evaluation system for cardiovascular effects of fiber materials
2019 - 2022 Role of non-apoptotic caspase in environmental electrophile-induced disorder of central nervous system
2017 - 2022 Biological Response to Environmental Stress: Epigenome/Proteome Analysis
2016 - 2019 Role of autophagy dysfunction in environmental electrophile-induced cognitive disorder
2014 - 2019 Epidemiological study on the effects of industrial nanomaterials on cardiovascular system
2014 - 2017 Animal model for cholangiocarcinoma associated with offset printing process
2014 - 2017 Elucidation of the ultimate carcinogen associated with occupational cholangiocarcinoma
2014 - 2017 Investigation on the effects of environmental stress on the cardiovascular system
2013 - 2016 Study of mechanisms for nanoparticle-induced inflammation and the development of safety evaluation methods for inflammation-related diseases.
2013 - 2016 Construction of an epigenetic epidemiology database for a population cohort
2012 - 2015 Investigation on neurodegenerative effect of 1-bromopropane using new biomarkers
2012 - 2015 Prediction of the genetic and epigenetic risk associated with lifestyle-relatied diseases in the population-based confirmatory factor analysis
2011 - 2013 Role of neurogenesis in mechanism of chronic or late-onset toxicity of environmental chemicals to the central nervous system
2010 - 2012 血液脳関門破綻と血管内皮障害とに共通する接着因子の作用メカニズムの解明
2010 - 2012 Study on oxidative stress and glial activation explaining demyelination in the central nervous system induced by alternative to freons
2009 - 2011 Investigation on toxicity of 1-bromopropane to central nervous system and hematopoetic function in humans
2008 - 2010 Physiological status depending on particle size in workers at the nano-handling factor
2006 - 2008 A role for the aryl hydrocarbon receptor in regulation of ischemia-induced angiogenesis
2006 - 2007 尿中代謝物測定による有機溶剤高感受性作業者スクリーニング法の開発
2004 - 2006 Investigation on protein adduct produced by alternatives to ozone-depleting substances and susceptibility genes and establishment of new method for risk assessment.
2003 - 2005 Research on the mechanism of generalized skin reaction caused by trichloroethylene exposure
2003 - 2004 Risk evaluation of the reproductive effects of chemicals acting on the nervous system in the occupationally exposed population
2002 - 2004 Investigation on neurologic abnormality induced by 1-bromoproane and individual variation in susceptibility
2002 - 2004 Adverse effects of endocrine-disrupting chemicals and the mechanism via nuclear receptor in relation to the risk assessment
2001 - 2003 INVESTIGATION ON TOXICITIES OF ALTERNATIVES FOR CHLOROFLUOROCARBONS AND ITS RISK ASSESSMENT USING MOLECULAR AND BIOLOGICAL MARKERS.
2000 - 2001 Ovarian Toxicity --Investigation of history of exposure to chemicals in infertility patients and an experimental study on a candidate chemical--
2000 - 2001 Development Deregulating system for inhalation exposure to volatile organic chemicals (VOCs) for toxicity testing
1999 - 2000 Study on mechanism of reproductive toxicity and neurotoxicity of 1-bromopropane, a new alternative to chlorofluorocarbons
1998 - 2000 Mechanistic studies on reproductive toxicity and neurotoxicity of alternatives to chlorofluorocarbons and their risk assessment
1998 - 2000 Surveys on reproductive toxicity of 2-bromopropane in humans
1998 - 1999 2-ブロモプロパンによる骨髄のアポトーシスと毒性評価における意義
1998 - 1999 Biological monitoring of organic solvents, alternative to chlorofluorocarbons
1995 - 1996 A study on the mechanism and biomarker of neurotoxicity of organic solvents.
1995 - 1995 蛇紋石産出地域における石綿・非石綿鉱物繊維暴露と住民の胸膜肥厚所見
1994 - 1994 混合溶剤によるヘキサンの神経毒性並びに生物学的モニタリングに対する影響
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Papers (240)：
Alzahraa Fergany, Cai Zong, Frederick Adams Ekuban, Bin Wu, Satoshi Ueha, Shigeyuki Shichino, Kouji Matsushima, Yoichiro Iwakura, Sahoko Ichihara, Gaku Ichihara. Transcriptome analysis of the cerebral cortex of acrylamide-exposed wild-type and IL-1β-knockout mice. Archives of toxicology. 2023
Alzahraa Fergany, Cai Zong, Frederick Adams Ekuban, Aina Suzuki, Yusuke Kimura, Sahoko Ichihara, Yoichiro Iwakura, Gaku Ichihara. Deletion of IL-1β exacerbates acrylamide-induced neurotoxicity in mice. Toxicological sciences : an official journal of the Society of Toxicology. 2023
Yusuke Kimura, Frederick Adams Ekuban, Cai Zong, Shigeyuki Sugie, Xiao Zhang, Ken Itoh, Masayuki Yamamoto, Sahoko Ichihara, Seiichiro Ohsako, Gaku Ichihara. Role of Nrf2 in 1,2-dichloropropane-induced cell proliferation and DNA damage in the mouse liver. Toxicological sciences : an official journal of the Society of Toxicology. 2023
Walaa Slouma Hamouda Abd El Naby, Cai Zong, Alzahraa Fergany, Frederick Adams Ekuban, Saleh Ahmed, Yousra Reda, Harue Sato, Sahoko Ichihara, Natsuko Kubota, Shinya Yanagita, et al. Exposure to Benzo[a]pyrene Decreases Noradrenergic and Serotonergic Axons in Hippocampus of Mouse Brain. International journal of molecular sciences. 2023. 24. 12
Russell C Cattley, Hans Kromhout, Meng Sun, Erik J Tokar, Mohamed A-E Abdallah, Alison K Bauer, Kendra R Broadwater, Laura Campo, Emanuela Corsini, Keith A Houck, et al. Carcinogenicity of anthracene, 2-bromopropane, butyl methacrylate, and dimethyl hydrogen phosphite. The Lancet. Oncology. 2023. 24. 5. 431-432
OHSAKO Seiichiroh, SUZUKI Soto, YADA Kentaro, UEHA Satoshi, CHEN Ming-Chen, OGIWARA Haru, MATSUSHIMA Kouji, ICHIHARA Gaku. Inflammatory bowel disease observed in the Ahr-null mice with an analysis of epigenome in genome-wide. Annual Meeting of the Japanese Society of Toxicology. 2020. 47.1. O-11
Some Industrial Chemicals, IARC Monographs on the Evaluation of Carcinogenic Risks to Humans; Volume115
International Agency for Research on Cancer 2018 ISBN:9789283201533
The role of IL-1ß in Acrylamide-induced Neurotoxicity in mice
(第49回日本毒性学会学術年会 2022)
RNA-Seq analysis of 1C11NE neurons reveals important roles of microglia and proteasome pathway in environmental electrophileinduced neurodegeneration
(第49回日本毒性学会学術年会 2022)
Molecular mechanism of arsenic-induced hypertension: Inhibition of the vasoprotective axes of the renin-angiotensin system by arsenite
(第49回日本毒性学会学術年会 2022)
- 1993 Nagoya University Graduate School, Division of Medicine
- 1987 Nagoya University Faculty of Medicine
Professional career (1)：
博士(医学) (名古屋大学)
Work history (7)：
2018/04 - 2022/03 Tokyo University of Science Health Management Center, Director
2006 - 2014 Nagoya University Graduate School of Medicine Associate Professor
2004 - 2014 Nagoya University Occupational Physician
2014 - Faculty of Pharmaceutical Sciences, Tokyo University of Science Professor
1998 - 2006 Nagoya University Graduate School of Medicine Associate Professor
1993 - 1998 Nagoya University School of Medicine Research Associate
1990 - 1993 Nagoya University Graduate School of Medicine Ph.D. student
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Committee career (27)：
2017/10 - 現在 日本医学会連合 教育および人材育成検討委員会 委員
2020/03/26 - 2024/03/25 日本衛生学会 代議員
2020/04/01 - 2023/03/31 ナノ・バイオメディカル学会 学会理事等
2020/03/01 - 2023/02/28 日本産業衛生学会 許容濃度等に関する委員会 委員
2020/06/22 - 2022/06/21 環境ホルモン学会 評議員
2020/05/25 - 2022/03/31 日本衛生学会 衛生学エキスパート制度運営委員
2019/06/27 - 2021/07/31 日本毒性学会 評議員
2018/10/01 - 2020/12/31 日本衛生学会 専門職制度対応委員
2018/06/22 - 2020/06/22 環境ホルモン学会 評議員
2017/04/01 - 2020/03/31 日本産業衛生学会 許容濃度等に関する委員会 委員
2017/04/01 - 2020/03/31 日本産業衛生学会 学会誌及び論文誌の編集者
2017/04/01 - 2020/03/31 ナノ・バイオメディカル学会 学会理事等
2017/07/11 - 2019/07/31 日本毒性学会 評議員
2017/06/28 - 2018/06/30 日本毒性学会 指針値検討小委員会委員
2016/06/17 - 2018/06/17 環境ホルモン学会 評議員
2014/04/01 - 2017/03/31 Japan Society of Toxicology 学会誌 Journal of Toxicological Sciences 編集委員
2014/04/01 - 2017/03/31 日本衛生学会 評議員
2014/04/01 - 2017/03/31 日本毒性学会 評議員
2014/04/01 - 2017/03/31 日本産業衛生学会 許容濃度等に関する委員会 委員
2014/04/01 - 2017/03/31 日本毒性学会 学会誌及び論文誌の編集者
2014/04/01 - 2017/03/31 日本産業衛生学会 学会誌及び論文誌の編集者
2011/04/01 - 2017/03/31 National Institute of Occupational Safety and Health Industrial Health(英文)誌 編集委員
2011/04/01 - 2017/03/31 労働安全衛生研究所 学会誌及び論文誌の編集者
2015/02/02 - 2017/02/01 Nature Pulishing Group Member of Editorial Board
2015/02/02 - 2017/02/01 Nature Pulishing Group Member of Editorial Board
2015/09/29 - 2016/01/25 Managing risk of nanomaterials (MARINA) Chairperson
2015/09/29 - 2016/01/25 Managing risk of nanomaterials (MARINA) 学会会長
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Awards (3)：
2015/11 - 日本学術振興会 科研費審査委員 表彰
2000/04 - 日本産業衛生学会 奨励賞
1982/04 - 竹中育英会 奨学生
Association Membership(s) (8)：
NANO BIOMEDICAL SOCIETY
, 環境ホルモン学会
, 日本衛生学会
, Japan Society for Occupational Health
, Japan Society of Toxicology
, National Institute of Occupational Safety and Health
, Nature Pulishing Group
, Managing risk of nanomaterials (MARINA)
