Kubo Takeo

Affiliation and department：
Job title： Professor
Homepage URL (1)： http://www.biol.s.u-tokyo.ac.jp/users/saibou/lab.html

Research field (4)： Molecular biology , Developmental biology , Neuroscience - general , Animals: biochemistry, physiology, behavioral science

Research keywords (7)：ケニヨン細胞 , キノコ体 , 尻振りダンス , 社会性行動 , ミツバチ , アフリカツメガエル , 器官再生

Research theme for competitive and other funds (29)：

2020 - 2023 Study on the molecular basis that defines organ regenerative ability in an anuran amphibian (Xenopus laevis)
2020 - 2023 Analyses of Kenyon cell type diversification in hymenopteran insect brains and its relationship with behavioral evolution
2014 - 2017 Study on the reactivation of regenerative ability by masking 'autoantigens' expressed in organ blastema.
2014 - 2017 Functional analysis of the 'middle-type' Kenyon cells that were newly identified in the honeybee brain in dance communication
2014 - 2017 Functional mapping of fish social brain

2013 - 2016 花粉媒介行動の脳の分子神経基盤とその生態系への影響の解明

2012 - 2014 アフリカツメガエルの器官再生に阻害的に働く自然炎症の分子機構の解析

2012 - 2014 Analysis of novel proteins abundantly expressed in extremo-tolerant tardigrades.

2011 - 2014 Analysis of the endocrine and neural mechanisms that synergistically regulate the behavior and physiology of the worker honeybees.

2010 - 2011 Identification and analysis of blastema-specific molecules that are targeted by immature immune system in Xenopus tadoples

2009 - 2010 ミツバチの視覚情報処理を支える脳のモジュール構造の分子的構築の解析

2006 - 2006 昆虫をモデルとした適応戦略の分子メカニズムに関する企画調査

2004 - 2005 Study on the molecular basis that underlies the dance language and aggressive behaviors of the honeybee.

2004 - 2004 行動研究のモデル生物としてのミツバチの開発と利用

2003 - 2004 攻撃的なミツバチの脳に感染するRNAウイルスの感染ルートと攻撃行動への関与の証明

2003 - 2003 ミツバチの脳に感染し、攻撃行動を誘発する新種のピコルナウイルスに関する研究

2001 - 2001 アフリカツメガエルの尾の再生に働く遺伝子の系統的検索と解析

2000 - 2001 消毒剤耐性変異の獲得に伴うMRSAのβラクタム系抗生物質耐性の上昇

2000 - 2001 Development of antibiotics by monitoring the inhibition of the ATP-binding to DnaA, the initiator protein of chromosomal DNA replication in bacteria

2000 - 2001 Identification and analysis of genes involved in the intrinsic behaviors of the social insect (the honey bee)

2000 - 2000 ミツバチの脳で領野特異的、行動特異的に発現する遺伝子の同定と解析

2000 - 2000 Molecular Mechanism of Insect Metamorphosis and Diapause

1999 - 2000 Study of the regulatory mechanism of DnaA protein, the initiator of DNA replication in Escherichia coli.

1996 - 1999 Molecular mechanisms of self / non-self recognition and tissue-remodeling during metamorphosis.

1997 - 1998 Identification and analysis of the genes that regurate the bahavior of the honeybee

1995 - 1996 Mechanisms of regeneration of insect imaginal discs.

1995 - 1995 昆虫の変態・休眠の分子機構に関する研究の企画調査

1992 - 1994 Defense mechanism of insect (Sarcophaga peregrina)

1991 - 1992 ワモンゴキブリの体液性レクチンの肢の再生に於ける機能解析と構造決定

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Papers (64)：

Hiroto Tadano, Hiroki Kohno, Hideaki Takeuchi, Takeo Kubo. Unique spatially and temporary-regulated/sex-specific expression of a long ncRNA, Nb-1, suggesting its pleiotropic functions associated with honey bee lifecycle. Scientific reports. 2024. 14. 1. 8701-8701
Hiroki Kohno, Shuichi Kamata, Takeo Kubo. Analysis of Antennal Responses to Motion Stimuli in the Honey Bee by Automated Tracking Using DeepLabCut. Journal of Insect Behavior. 2024
Yasuhiro Matsumura, Hiroki Kohno, Takeo Kubo. Possible functions of ecdysone signaling reiteratively used in the adult honey bee brain. Frontiers in Bee Science. 2023. 1
Shiori Iino, Satoyo Oya, Tetsuji Kakutani, Hiroki Kohno, Takeo Kubo. Identification of ecdysone receptor target genes in the worker honey bee brains during foraging behavior. Scientific reports. 2023. 13. 1. 10491-10491
Takayoshi Kuwabara, Hiroki Kohno, Masatsugu Hatakeyama, Takeo Kubo. Evolutionary dynamics of mushroom body Kenyon cell types in hymenopteran brains from multifunctional type to functionally specialized types. Science advances. 2023. 9. 18. eadd4201

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MISC (38)：

松村泰宏, 河野大輝, 久保健雄. Developmental stage-specific expression analysis of Mblk-1, a transcription factor involved in ecdysteroid-signaling in the honey bee brain. 昆虫と自然. 2021. 56. 1
河野大輝, 久保健雄. ミツバチの社会性行動の分子生物学遺伝子から探るミツバチの脳の仕組み (特集ミツバチ新時代). 遺伝 : 生物の科学. 2019. 73. 6. 596-602
Atsuhiro Yamane, Hiroki Kohno, Tsubomi Ikeda, Kumi Kaneko, Atsushi Ugajin, Toshiyuki Fujita, Takekazu Kunieda, Takeo Kubo. Correction: Gene expression and immunohistochemical analyses of mKast suggest its late pupal and adult-specific functions in the honeybee brain (vol 12, e0183522, 2017). PLOS ONE. 2017. 12. 10
河野大輝, 佐々木哲彦, 久保健雄. Development of genome-editing techniques in the honeybee : its future prospects. 昆虫と自然. 2017. 52. 10. 36-39
橋本拓磨, 斎藤裕樹, 尾山大明, 秦裕子, 榎本敦, 宮川清, 桑原宏和, 堀川大樹, 豊田敦, 片山俊明, et al. 放射線耐性を示すクマムシの新規タンパク質S261によるDNA損傷の抑制. 日本放射線影響学会大会講演要旨集. 2014. 57th. 121

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Professional career (1)：

博士(薬学)

Work history (5)：

2001/04 - 現在 The University of Tokyo Graduate School of Science, Department of Biological Sciences
1997/04 - 2001/03 The University of Tokyo Graduate School of Pharmaceutical Sciences
1995/07 - 1997/03 The University of Tokyo Faculty of Pharmaceutical Sciences
1992/12 - 1995/06 The University of Tokyo Faculty of Pharmaceutical Sciences
1987/11 - 1992/11 The University of Tokyo Faculty of Pharmaceutical Sciences

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