Rchr
J-GLOBAL ID：200901028808270900   Update date: Nov. 03, 2024

Toma-Fukai Sachiko

トウマ サチコ | Toma-Fukai Sachiko
Affiliation and department：
Nara Institute of Science and Technology Graduate School of Science and Technology

About Nara Institute of Science and Technology Graduate School of Science and Technology


Job title： Associate Professor
Research field  (1)： Structural biochemistry
Research keywords  (3)： Structural Biology ,  Biochemistry ,  物理系薬学
Research theme for competitive and other funds  (10)：
  • 2021 - 2026 不可逆的タンパク質メチル化を介した進行性および加齢性心腎障害の分子基盤
  • 2021 - 2024 Transportin-1が担う非古典的核輸送機構解明に向けた構造生物研究
  • 2023 - 2023 脳上衣腫治療薬創成を目指した構造生物研究
  • 2018 - 2022 Structural study of the PCAF-HD domain of GCN5 to reveal signaling in hepatic glucogenesis
  • 2019 - 2019 高分解能立体構造解析から明らかにするPPARgの核輸送機構
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Papers (28)：
  • Sachiko TOMA-FUKAI, Yutaro Nakamura, Akihiro Kawamoto, Hikaru Shimizu, Koki Hayama, Ruri Kojima, Kanami Yoshimura, Masaki Ishii, Mika Hirose, Toshiaki Teratani, et al. Structural insight into the nuclear transportation mechanism of PPARg by Transportin-1. 2024
  • Hiroaki Matsuura, Naoki Sakai, Sachiko Toma-Fukai, Norifumi Muraki, Koki Hayama, Hironari Kamikubo, Shigetoshi Aono, Yoshiaki Kawano, Masaki Yamamoto, Kunio Hirata. Elucidating polymorphs of crystal structures by intensity-based hierarchical clustering analysis of multiple diffraction data sets. Acta crystallographica. Section D, Structural biology. 2023. 79. Pt 10. 909-924
  • Honami Echizen, Kenjiro Hanaoka, Kazuhito Shimamoto, Ryota Hibi, Sachiko Toma-Fukai, Hisashi Ohno, Eita Sasaki, Toru Komatsu, Tasuku Ueno, Yukihiro Tsuchiya, et al. Discovery of a cystathionine γ-lyase (CSE) selective inhibitor targeting active-site pyridoxal 5'-phosphate (PLP) via Schiff base formation. Scientific reports. 2023. 13. 1. 16456-16456
  • Sachiko Toma-Fukai, Yuto Sawada, Ayako Maeda, Hikaru Shimizu, Toshiharu Shikanai, Mizuki Takenaka, Toshiyuki Shimizu. Structural insight into the activation of an Arabidopsis organellar C-to-U RNA editing enzyme by active site complementation. The Plant cell. 2023. 35. 6. 1888-1900
  • Yoshihiro Yamaguchi, Koichi Kato, Yoshimi Ichimaru, Yuya Uenosono, Sakiko Tawara, Rio Ito, Natsuki Matsuse, Jun-Ichi Wachino, Sachiko Toma-Fukai, Wanchun Jin, et al. Difference in the Inhibitory Effect of Thiol Compounds and Demetallation Rates from the Zn(II) Active Site of Metallo-β-lactamases (IMP-1 and IMP-6) Associated with a Single Amino Acid Substitution. ACS infectious diseases. 2023. 9. 1. 65-78
ｍore...
MISC (65)：
  • Sachiko TOMA-FUKAI. Structural insight into nuclear transportation mechanism of PPARg. Advances In Pharmaceutical Sciences. 2023. 39. 59-63
  • 藤間祥子, 藤間祥子, 澤田優斗, 前田彩子, 清水光, 鹿内利治, 竹中瑞樹, 清水敏之. 植物オルガネラC-to-U RNA編集酵素DYW1の結晶構造解析. 日本結晶学会年会講演要旨集. 2023. 2023
  • 竹中瑞樹, 藤間祥子, BRODY Frink, WANG Tenghua, 竹中佐知, 鹿内利治, 清水敏之. Activation of a plant organellar C-to-U RNA editing enzyme by complex formation. 日本植物生理学会年会(Web). 2023. 64th
  • 藤間祥子, 中村雄太郎, 寺谷俊昭, 川本晃大, 清水光, 廣瀬未果, 端山浩輝, 大畑慎也, 林有吾, 山崎洋一, et al. Structural insight into the nuclear transport mechanism of PPARg. 日本薬学会年会要旨集(Web). 2022. 142nd
  • 藤間祥子, 藤間祥子, 澤田優斗, 前田彩子, 清水光, 鹿内利治, 竹中瑞樹, 清水敏之. Structural study of plant organellar C-to-U RNA editing enzyme DYW-1. 量子ビームサイエンスフェスタ(Web). 2022. 2021
ｍore...
Lectures and oral presentations  (22)：
  • Structural study of the nuclear transportation mechanism of PPARg by Transportin-1
    (3rd Joint International Symposium of National Synchrotron Radiation Research Center, Taiwan Institute for Protein Research, Osaka University, Japan 2024)
  • Frontiers of Structural Biology for Drug Design: Structural insight into the nuclear transportation of ependymoma-driving ZFTA-RELA fusion Protein
    (Protein Biochemistry & Biotechnology Symposium 2024)
  • クライオ電子顕微鏡とX線結晶構造解析から明らかにするTransportin-1によるカーゴ認識機構の多様性
    (日本結晶学会年会 (2023年)シンポジウム名:蛋白質結晶学者がクライオ電子顕微鏡で見つめる新しい世界 2023)
  • Frontiers of Structural Biology for Drug Design
    (NAIST-NYCU Joint Seminar 2023)
  • Structural insight into the activation of an Arabidopsis organellar C-to-U RNA editing enzyme by active site complementation.
    (The Plant Cell webinar on RNA Biology 2023)
ｍore...
Education (4)：
  • 2006 - Osaka University Graduate School of Science
  • 2001 - 2003 Osaka University Graduate School of Science Department of Macromolecular Science
  • 1999 - 2001 Ochanomizu University
  • 1995 - 1999 Ochanomizu University Faculty of Science Division of Chemistry
Professional career (1)：
  • 博士(理学) (大阪大学)
Work history (7)：
  • 2024/07 - 現在 Nara Institute of Science and Technology
  • 2018/10 - 現在 Nara Institute of Science and Technology
  • 2018/04 - 2018/09 Ochanomizu University Faculty of Science
  • 2007/04 - 2018/09 The University of Tokyo Graduate School of Pharmaceutical Sciences
  • 2017/09 - 2017/09 Ochanomizu University Graduate School of Humanities and Sciences
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Committee career (24)：
  • 2024/04 - 現在 日本薬学会 物理系薬学部会 ブロック選出世話人(近畿) ブロック選出世話人(近畿)
  • 2021/06 - 現在 CBI研究機構 量子構造生命科学研究所 個人会員
  • 2021/04 - 2027/03 大学共同利用機関法人 高エネルギー加速器研究機構 物質構造科学研究所放射光共同利用実験審査委員会委員
  • 2023/09 - 2026/08 International Union of Crystallography Member of Gender Equity and Diversity Committee
  • 2024/06 - 2026/06 日本蛋白質科学会 代議員, 執行役員 (男女参画役員)
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Awards (1)：
  • 2024 - 日本結晶学会 学術賞 転写・翻訳後修飾が制御する生命現象の構造生物学的解明
Association Membership(s) (4)：
THE PHARMACEUTICAL SOCIETY OF JAPAN ,  日本結晶学会 ,  Protein Science Society of Japan ,  THE JAPANESE BIOCHEMICAL SOCIETY
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