Kawauchi Daisuke

カワウチダイスケ | Kawauchi Daisuke

Affiliation and department：
Job title： Professor

Research field (3)： Tumor biology , Developmental biology , Neuroscience - general

Research keywords (11)： cancer epigenetics , Brain microenvironment , 上衣腫 , ゲノム編集 , oncogene , Electroporation , Pediatric brain tumor , cancer stem cell , cerebellum , medulloblastoma , neuronal differentiation

Research theme for competitive and other funds (10)：

2023 - 2026 N/A
2023 - 2026 N/A
2022 - 2025 Understanding of functional interaction between tumor cells and brain microenvironment in brain tumor development
2022 - 2025 手術検体を用いた脳腫瘍細胞と正常神経細胞間のてんかん原性回路の解明
2020 - 2022 The study of novel therapeutic avenues for pediatric brain tumors based on molecular mechanisms of their tumorigenesis

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Papers (48)：

Ryo Shiraishi, Gabriele Cancila, Kohei Kumegawa, Jacob Torrejon, Irene Basili, Flavia Bernardi, Patricia Benites Goncalves da Silva, Wanchen Wang, Owen Chapman, Liying Yang, et al. Cancer-specific epigenome identifies oncogenic hijacking by nuclear factor I family proteins for medulloblastoma progression. Developmental cell. 2024. 59. 17. 2302-2319
David R Ghasemi, Konstantin Okonechnikov, Anne Rademacher, Stephan Tirier, Kendra K Maass, Hanna Schumacher, Piyush Joshi, Maxwell P Gold, Julia Sundheimer, Britta Statz, et al. Compartments in medulloblastoma with extensive nodularity are connected through differentiation along the granular precursor lineage. Nature communications. 2024. 15. 1. 269-269
Konstantin Okonechnikov, Piyush Joshi, Mari Sepp, Kevin Leiss, Ioannis Sarropoulos, Florent Murat, Martin Sill, Pengbo Beck, Kenneth Chun-Ho Chan, Andrey Korshunov, et al. Mapping pediatric brain tumors to their origins in the developing cerebellum. Neuro-oncology. 2023. 25. 10. 1895-1909
Takayoshi Watanabe, Hayato Laurence Mizuno, Jumpei Norimatsu, Takumi Obara, Horacio Cabral, Kouhei Tsumoto, Makoto Nakakido, Daisuke Kawauchi, Yasutaka Anraku. Ligand Installation to Polymeric Micelles for Pediatric Brain Tumor Targeting. Polymers. 2023. 15. 7
Yong Ha Youn, Shirui Hou, Chang-Chih Wu, Daisuke Kawauchi, Brent A Orr, Giles W Robinson, David Finkelstein, Makoto M Taketo, Richard J Gilbertson, Martine F Roussel, et al. Primary cilia control translation and the cell cycle in medulloblastoma. Genes & development. 2022. 36. 11-12. 737-751

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MISC (36)：

Melanie Schoof, Michael Spohn, Mario Dorostkar, Sina Neyazi, Michael Bockmayr, Fredrik Swartling, Daisuke Kawauchi, Richard Gilbertson, Jessica Taylor, Yanxin Pei, et al. ARRAY-BASED GLOBAL DNA METHYLATION PROFILING OF MOUSE BRAIN TUMORS ALLOWS COMPARISON TO HUMAN TUMORS. NEURO-ONCOLOGY. 2022. 24. 158-159
Ryo Shiraishi, Gabriele Cancila, Kohei Kumegawa, Patricia da Silva, Owen Chapman, Wang Wanchen, Maki Jami, Mikio Hoshino, Stefan Pfister, Lukas Chavez, et al. DYNAMIC CHROMATIN ALTERATION INDUCES ONCOGENIC HIJACKING BY ESSENTIAL TRANSCRIPTIONAL FACTORS DURING SHH MEDULLOBLASTOMA TUMORIGENESIS. NEURO-ONCOLOGY. 2022. 24. 107-108
Tuyu Zheng, Martin Sill, Roland Imle, Ryo Shiraishi, Wanchen Wang, Alaide Morcavallo, Louis Chesler, Daisuke Kawauchi, Olivier Ayrault, Lutsik Pavlo, et al. DNA METHYLATION-BASED BIOBANK OF MURINE MODELS FOR PEDIATRIC TUMORS. NEURO-ONCOLOGY. 2022. 24. 169-170
Tuyu Zheng, David R. Ghasemi, Konstantin Okonechnikov, Andrey Korshunov, Kendra K. Maass, Martin Sill, Johannes Gojo, Ulrich Schueller, Till Milde, Stephen C. Mack, et al. ZFTA/C11ORF95 FUSIONS DRIVE SUPRATENTORIAL EPENDYMOMA VIA SHARED ONCOGENIC MECHANISMS. NEURO-ONCOLOGY. 2021. 23. 13-14
Ryo Shiraishi, Mana Shimoda, Reo Maruyama, Daisuke Kawauchi. Analysis of epigenetic alteration required for malignant transformation of pre-neoplastic cells in a brain tumor. CANCER SCIENCE. 2021. 112. 849-849

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Patents (3)：

Drug for ZFTA fusion-subgroup ependymoma
神経膠腫治療剤、および神経膠腫細胞の増殖抑制方法
抗腫瘍剤、抗腫瘍剤のスクリーニング方法、および予後検査薬

Books (1)：

疾患原因遺伝子・タンパク質の解析技術と創薬/診断技術への応用
技術情報協会 2022 ISBN:9784861048777

Lectures and oral presentations (12)：

Conditional expression and activation of DREADDs reveals novel impact of neuron-tumor communications on brain tumor progression
(2024)
Dynamic chromatin alteration causes oncogenic hijacking by NFIA/B during medulloblastoma tumorigenesis
(The 82nd Annual Meeting of the Japanese Cancer Association 2023)
Conditional expression and activation of DREADDs reveals novel impact of neuron-tumor communications on brain tumor progression.
(1st Heidelberg Conference on Cancer Neuroscience 2023)
Discovery of Novel Oncogenic Signaling for Pediatric Brain Tumors via Understanding of Human Cancer Genomes
(The 9th US-JAPAN Conference on Oncology 2022)
Discovery and Understanding of Oncogenic Fusion Genes in Ependymoma
(2022)

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Education (2)：

1999 - 2004 Osaka University
1995 - 1999 Osaka University School of Science

Professional career (1)：

Ph. D (Osaka University)

Work history (8)：

2024/04 - 現在 Nagoya City University Graduate School of Medical Sciences, Institute of Brain Science, Department of Neuro-oncology Professor
2023/04 - 2024/03 Graduate School of Medicine, Science and Technology, Shinshu University Specially appointed associate professor
2019/12 - 2024/03 National Center of Neurology and Psychiatry
2018/08 - 2019/11 ドイツ癌研究センター小児脳腫瘍学テニュアグループリーダー
2013/05 - 2018/07 ドイツ癌研究センター小児脳腫瘍学テニュアトラック・グループリーダー

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Committee career (2)：

2023 - 現在 Curie institut, France PhD thesis committee
2015/01 - 2015/06 Curie institut, France PhD thesis committee

Awards (6)：

2023/06 - Fudan University Fudan University Visiting Scholar
2020 - Brain Tumour Charity Collaborative Team Award (GN-000690) Targeting Src as a Driver of CNS Grp 4 Medulloblastoma and Glioma
2017 - Brain Tumour Charity Collaborative Team Award (GN-000356) Identification, in-vivo modelling and therapeutic targeting of superenhancer-driven oncogenes in Group 3 medulloblastoma
2011 - St Jude intramural grant: The Anderson fellowship
2009 - 公益財団法人持田記念医学薬学振興財団留学補助金

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Association Membership(s) (5)：

JSNO , 日本分子生物学会 , 日本癌学会 , 日本神経科学学会 , 北米癌学会

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