Research field (2)：
Environmental effects of chemicals
, Environmental effects of radiation
Research keywords (2)：
分子生物
, Molecular biology
Research theme for competitive and other funds (23)：
2021 - 2024 放射線誘発甲状腺癌の発症リスクを高める遺伝的素因はあるのか?
2019 - 2023 Genome-wide gene-environmental interaction analysis of exposures to radiation and nitrates as modifiers of the risk for thyroid cancer in the Chernobyl region
2019 - 2022 Molecular epidemiological study of radiation-induced juvenile thyroid cancer
2016 - 2020 Molecular epidemiological study of radiation-free pediatric and adolescent thyroid cancers around the Chernobyl area.
2016 - 2019 Molecular epidemiological study of radiation-induced childhood thyroid cancer
2016 - 2019 Mitochondrial DNA deletions as a bioindicator of radiation exposure in papillary thyroid carcinoma
2016 - 2019 Molecular epidemiological study of thyroid cancers by international collaboration
2014 - 2019 The molecular epidemiological study of DNA repair-related genes in post-Chernobyl radiation-induced thyroid cancers
2015 - 2018 Establishment of a synthetic promoter-based system for sensing oncogenic alteration in human live thyroid cells at a single-cell level
2014 - 2018 Elucidation of Prognostic Markers and their Molecular Mechanism for Thyroid Cancer
2014 - 2016 Provocative epidemiological study on identification of factor of thyroid carcinogenesis
2013 - 2016 Molecular Epidemiological Study on Risk of Radiation-associated Cancer after the Chernobyl Nuclear Power Plant accident
2012 - 2015 Establishment of Chernobyl paraffin-embedded tissue Bank and discovering of new oncogene
2012 - 2015 Do thyroid cancer risk factors FOXE1 and NKX2-1 influence risk of development of a benign adenoma?
2010 - 2012 Elucidation of molecular mechanism on thyroid carcinogenesis anddevelopmental application of molecular targeting therapy
2010 - 2012 Large-scale cohort molecular epidemiological study after the Chernobyl accident
2009 - 2011 Novel insights into the effect protecting DNA from radiation-induced damage : identification of relevant factors involved in paracrine epithelial-mesenchymal cell interactions
2007 - 2009 Elucidation of thyroid carcinogenesis and clinical application of molecular targeting therapy
2007 - 2009 Elucidation of a novel mechanism of epithelial-mesenchymal cells cross-talk leading to the reducation of radiation-induced DNA damage
2007 - 2008 Elucidation of a novel mechanism of epithelial-mesenchymal cells cross-talk leading to the reduction of radiation-induced DNA damage
2003 - 2008 放射線誘発ヒト甲状腺癌の分子疫学的研究
2003 - 2008 Molecular epidemiology of radiation-induced human thyroid cancer
2002 - 2004 Prevalence of mitochondrial DNA mutations in radiation associated human thyroid tumors
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Papers (118)：
Ayaka Sako, Michiko Matsuse, Vladimir Saenko, Aya Tanaka, Ryota Otsubo, Michi Morita, Sayaka Kuba, Eijun Nishihara, Keiji Suzuki, Tomoo Ogi, et al. TERT promoter mutations increase tumor aggressiveness by altering TERT mRNA splicing in papillary thyroid carcinoma. The Journal of clinical endocrinology and metabolism. 2024
Tetiana Bogdanova, Tatiana I. Rogounovitch, Liudmyla Zurnadzhy, Norisato Mitsutake, Mykola Tronko, Masahiro Ito, Michael Bolgov, Serhii Chernyshov, Serhii Gulevatyi, Sergii Masiuk, et al. Characteristics and immune checkpoint status of radioiodine-refractory recurrent papillary thyroid carcinomas from Ukrainian Chornobyl Tissue Bank donors. Frontiers in Endocrinology. 2024. 14. 1343848-1343848
Tetiana Bogdanova, Serhii Chernyshov, Liudmyla Zurnadzhy, Tatiana I. Rogounovitch, Norisato Mitsutake, Mykola Tronko, Masahiro Ito, Michael Bolgov, Sergii Masiuk, Shunichi Yamashita, et al. The relationship of the clinicopathological characteristics and treatment results of post-Chornobyl papillary thyroid microcarcinomas with the latency period and radiation exposure. Frontiers in Endocrinology. 2022. 13. 1078258-1078258
Tetiana Bogdanova, Serhii Chernyshov, Liudmyla Zurnadzhy, Tatiana I. Rogounovitch, Norisato Mitsutake, Mykola Tronko, Masahiro Ito, Michael Bolgov, Sergii Masiuk, Shunichi Yamashita, et al. The high degree of similarity in histopathological and clinical characteristics between radiogenic and sporadic papillary thyroid microcarcinomas in young patients. Frontiers in Endocrinology. 2022. 13. 970682-970682
Expression of PD-L1 and PD-1 in poorly differentiated thyroid carcinoma as a means of selecting patients for immunotherapy
(The 66th Annual Meeting of the Japan Thyroid Association 2023)
Primary tumors and recurrent radioiodine-resistant metastases of PTC have highly concordant immune checkpoint status
(The 66th Annual Meeting of the Japan Thyroid Association 2023)
2010/11 - 日本甲状腺学会 第7回 日本甲状腺学会基礎医学研究奨励賞 Molecular epidemiology study of papillary thyroid carcinoma developing after internal exposure to radioiodine in Chernobyl
