Rchr

J-GLOBAL ID：200901029477678056 Update date: Oct. 04, 2024

Kobayashi Takaaki

コバヤシタカアキ | Kobayashi Takaaki

Affiliation and department：
Homepage URL (2)： http://www.aichi-med-u.ac.jp/hospital/sh04/sh0402/sh040216/index.html , https://www.aichi-med-u.ac.jp.e.gy.hp.transer.com/su06/su0607/su060703/26.html

Research field (2)： Immunology , General surgery, pediatric surgery

Research keywords (8)：エピトープ解析 , 主要組織適合性抗原 HLA , 異種移植 , 移植免疫 , 臓器移植 , Xenotransplantation , Transplant Immunology , Organ Transplantation

Research theme for competitive and other funds (46)：

2024 - 2027 ヒト化マウスを用いたドナー特異的抗体産生核酸の同定・機能解明と診断治療への応用
2021 - 2024 ヒト化マウスによるドナー特異的抗体産生免疫プロファイリングの解明と個別化医療
2021 - 2024 非翻訳RNAに着目したCNI腎症早期発見システムの構築
2021 - 2024 Identification of Indirect Alloreactive T-Cells and Application to Monitoring of anti-Donor Antibody Sensing
2020 - 2023 Identification and control of follicular helper T cell clonotype related to donor specific HLA antibody production

2020 - 2023 From treatment to prevention: development of innovative immune regulation based on epitope/paratope analysis

2019 - 2022 Application of gas mediator delivery system for the expanded criteria donor organs

2019 - 2021 BK virus monitoring system in kidney Transplantation

2019 - 2021 Individualized immune monitoring for long-term graft survival after organ transplantation

2018 - 2020 Multifaceted approach to HLA antibody producing B cells for controlling donor specific antibody (DSA)

2015 - 2019 Therapeutic strategies for anti-donor HLA antibody-producing plasma cells using RNA interference

2018 - 2019 Introduction of precision medicine in renal transplantation: attempt to overcome HLA mismatch by TCR/BCR control

2017 - 2019 Potential bias of T cell subgroup and endothelial response after anti-A/B antibody binding : Innovation in antibody-positive transplantation

2016 - 2018 Prophylactic and preemptive treatment for chronic antibody mediated rejection to achieve long-term kidney graft survival

2016 - 2018 Risk-benefit analysis of ABO-incompatible renal transplantation and development of antibody treatment

2015 - 2017 Novel approach for desensitization therapy and immunological tolerance by multifunctional suppressive B cell in organ transplantation

2015 - 2017 Analysis of diversity in antibody function and strategy: Establishment of pig models for ABO-incompatible and HLA-incompatible transplantation

2014 - 2016 Prevention of chronic graft rejection by signal transduction pathway towards resistance to antibody-mediated injury”

2013 - 2015 Multifunction analysis of thrombomodulin and development of novel clinical treatment

2013 - 2015 Multidisciplinary strategy to control chronic antibody mediated rejection in renal transplantation

2011 - 2014 The CD47-SIRPa signaling blockade accelerates macrophage phagocytic activity against cancer cells

2012 - 2014 Novel treatment for chronic rejection using living body-derived suppressive humoral immune system

2012 - 2013 免疫順応を誘導する、HLA-class II 分子結合タンパク質の同定・機能解析(24791371)

2012 - 2013 Establishment of in vitro B cell differentiation system from peripheral B cells to plasma cells

2011 - 2013 Establishment of comprehensive support system by pharmacological and immunological monitoring

2011 - 2013 Cancer therapy through CD47-SIRP alpha signal transduction

2010 - 2012 Development of a new immunosuppressive therapy using adipose derived mesenchymal stem cell

2010 - 2012 Significance of coagulation control in antibody-mediated rejection: Development of new assay and treatment

2010 - 2012 Introduction of novel pharmacodynamics analysis to transplantation medicine: Effect of immunosuppressive agents on B cell

2010 - 2011 抗体関連型慢性拒絶反応を回避するのシグナル伝達の解明(22791246)

2009 - 2011 Novel evaluation method of immune tolerance by analyzing donor-specific regulatory T cells

2009 - 2011 Development of immunological tolerance using cloned pigs expressing human blood type ABH

2007 - 2011 Development of pig models for organ transplantation

2008 - 2010 Individualized immunosuppressive therapy using pharmacological, immunological and molecular biological analysis

2008 - 2010 Dynamism analysis on antigen, antibody, complement, inflammation and coagulation associated with rejection, accommodation and tolerance

2008 - 2009 内皮細胞における抗原抗体反応後に起こるシグナル伝達に関する研究(20890098)

2008 - 2009 Tailoring Immunosuppression using pharmacodynamics analysis

2006 - 2008 The generation of clone pigs expressing blood group antigens -developing a tolerance induction method-

2006 - 2008 Production of cloned pigs expressing human blood type - Attempt to induce immune tolerance

2006 - 2007 Antigen removal in grafts and induction of accommodation for overcoming ABO incompatibility

2005 - 2005 Feasibility of industrialization and practical application in genetically engineered animals using primordial germ cells or somatic cells, and development of production technology for medical supply: Development of model pigs for transplantation

2001 - 2002 Molecular control of humoral rejection in organ transplantation

1999 - 2000 Antisense peptide of immune-related factors in organ transplantation

1999 - 2000 Endothelium-directed molecular strategy to overcome xenograft rejection

1997 - 1998 Molecular modification and immune tolerance in targeted organ

1996 - 1996 Basic study on immune tolerance by veto activity via cell death

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Papers (148)：

Yuko Miwa, Kenta Iwasaki, Kenta Murotani, Manabu Okada, Takaharu Nagaska, Yoshihiko Watarai, Asami Takeda, Masato Shizuku, Satoshi Ashimine, Kohei Ishiyama, et al. C1q binding ability for prior risk assessment of antibody-mediated rejection in ABOincompatible kidney transplantation. Transplant International. 2024. Accepted
Tatsuya Yamazaki, Kenta Iwasaki, Susumu Tomono, Masaki Imai, Yuko Miwa, Masato Shizuku, Satoshi Ashimine, Kohei Ishiyama, Masanori Inui, Daisuke Okuzaki, et al. Human RP105 monoclonal antibody enhances antigen-specific antibody production in unique culture conditions. iScience. 2024. 27. 9
Takahisa Hiramitsu, Tomoki Himeno, Yuki Hasegawa, Kenta Futamura, Manabu Okada, Yutaka Matsuoka, Norihiko Goto, Toshihiro Ichimori, Shunji Narumi, Asami Takeda, et al. Impact of Age 70 years or Older on Donors for Living-Donor Kidney Transplantation. Kidney International Reports. 2024. 9. 5. 1321-1332
Morikuni Nishihira, Yutaka Matsuoka, Mayuko Hori, Makoto Tsujita, Kaoru Yasuda, Satoshi Ashimine, Kohei Ishiyama, Kazuharu Uchida, Kunio Morozumi, Takaaki Kobayashi. Low skeletal muscle mass index is independently associated with low bone mineral density in kidney transplant recipients: a retrospective observational cohort study. Journal of Nephrology. 2024
David K.C. Cooper, Takaaki Kobayashi. Xenotransplantation experiments in brain-dead human subjects-A critical appraisal. American Journal of Transplantation. 2024. 24. 4. 520-525

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MISC (599)：

松岡直也, 岩崎研太, 小林孝彰, 伊藤恭彦. 尿蛋白によるオートファジー誘導阻害と細胞傷害の可能性. 移植. 2018. 53. 総会臨時. 480-480
前仲亮宏, 岩崎研太, 三輪祐子, 堀見孔星, 松岡裕, 友杉俊英, 奥村真衣, 打田和治, 斎藤寛子, 小林孝彰. 内皮細胞内誘導性HLA class IIは免疫抑制剤により制御される. MHC: Major Histocompatibility Complex. 2018. 25. 2. 133-133
友杉俊英, 小林孝彰, 奥村真衣, 松岡裕, 堀見孔星, 三輪祐子, 岩崎研太, 打田和治, 渡井至彦. De novo DSA産生抑制に関与し得るHLAアリルの検討. MHC: Major Histocompatibility Complex. 2018. 25. 2. 135-135
岩崎研太, 前仲亮宏, 小林孝彰. 内皮細胞HLAの発現抑制シグナルの同定と薬剤探索. Organ Biology. 2018. 25. 2. 140-144
渡邉恵, 前淵恵美, 今野悠美, 柴田裕紀, 松岡裕, 堀見孔星, 畔柳佳幸, 永井琢人, 小林孝彰. 生体腎移植予定で自己管理が必要な患児に対する指導. 日本小児腎不全学会雑誌. 2018. 38. 256-258

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Books (1)：

Xenotransplantation Ethical, Regulatory and Social Aspects, edited by Daniel J Hurst, Luz Padilla and Wayne D. Paris)
2023 ISBN:9783031290701

Professional career (2)：

PhD (Nagoya University)
MD (Nagoya University)

Work history (13)：

2015/04 - 現在 Aichi Medical University School of Medicine Renal Transplant Surgery Professor
2012/04 - 2015/03 Nagoya University Graduate School of Medicine Transplant Immunology Professor
2007/04 - 2012/03 Nagoya University School of Medicine Applied Immunology Professor
2005/11 - 2007/03 Nagoya University Graduate School of Medicine International Affairs Assistant Dean
2002/07 - 2004/06 Nagoya University School of Medicine Surgery II Assistant Professor

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Committee career (12)：

2025/10 - 2025/10 The 61st Annual Congress of the Japan Society for Transplantation President
2023/02 - 2023/02 25th Annual Meeting of Japanese Society for Xenotransplantation Congress President
2019/09 - 2019/09 日本組織適合性学会大会大会長
2013/11 - 2015/11 International Xenotransplantation Association (President) 会長
2013/11 - 2015/11 International Xenotransplantation Association President-Elect

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Awards (1)：

2018/10 - 厚労省厚生労働大臣感謝状

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