Research field (2)：
Bioorganic chemistry
, Structural/physical organic chemistry
Research keywords (4)：
核受容体
, ビタミンD
, Nuclear Receptor
, Vitamin D
Research theme for competitive and other funds (2)：
ビタミンD誘導体の合成研究
Synthesis of vitamin D analogues
Papers (16)：
Toshie Fujishima, Takuro Komatsu, Yuri Takao, Wataru Yonamine, Tsutomu Suenaga, Hiroaki Isono, Masayuki Morikawa, Keisuke Takaguchi. Design and concise synthesis of novel vitamin D analogues bearing a functionalized aromatic ring on the side chain. Tetrahedron. 2019. 75. 8. 1098-1106
Fujishima, T, Tsutomu, S, Kawahata, M, Yamaguchi, K. Synthesis and characterization of 20-hydroxyvitamin D3 with the A-ring modification. J. Steroid Biochem. Mol. Biol. 2018. 187. 27-33
Toshie Fujishima, Takato Nozaki, Tsutomu Suenaga. Design and synthesis of novel 1,25-dihydroxyvitamin D-3 analogues having a spiro-oxetane fused at the C2 position in the A-ring. BIOORGANIC & MEDICINAL CHEMISTRY. 2013. 21. 17. 5209-5217
Saito N, Suhara Y, Abe D, Kusudo T, Ohta M, Yasuda K, Sakaki T, Honzawa S, Fujishima T, Kittaka A. Synthesis of 2alpha-propoxy-1alpha,25-dihydroxyvitamin D3 and comparison of its metabolism by human CYP24A1 and rat CYP24A1. Bioorganic & medicinal chemistry. 2009. 17. 13. 4296-4301
Fujishima T, Tsutsumi R, Negishi Y, Fujii S, Takayama H, Kittaka A, Kurihara M. Methyl-introduced A-ring analogues of 1alpha,25-dihydroxyvitamin D3: synthesis and biological evaluation. Anticancer research. 2006. 26. 4A. 2633-2636
Design, Synthesis, and Biological Studies of the A-Ring-Modified 1,25-Dihydroxyvitamin D3 Analogs
Recent Results of Cancer Research, Antitumor Effects of Vitamin D Analogs 2003
Design, Synthesis, and Biological Studies of the A-Ring-Modified 1,25-Dihydroxyvitamin D3 Analogs
Recent Results of Cancer Research, Antitumor Effects of Vitamin D Analogs 2003
Works (4)：
ビタミン D 誘導体の代謝研究
2002 -
Metabolism of vitamin D analoguesr
2002 -
ビタミン D 誘導体の受容体結合様式解析
2000 -
Binding modes of vitamin D analogues to vitamin D receptor
2000 -
Education (2)：
The University of Tokyo Faculty of Pharmaceutical Sciences
The University of Tokyo
Professional career (2)：
Doctor of Philosophy (The University of Tokyo)
Master (The University of Tokyo)
Work history (1)：
2024/04 - Teikyo University Faculty of Pharmaceutical Sciences
