2019 - 2022 Analysis of the molecular mechanism of LSR ligand-dependent atypical macropinocytosis and following multilayered cell growth.
2019 - 2022 Analyses of malignant mechanisms via abnormality of novel multifunctional tricellular junction molecules in cancer cells
2020 - 2021 マクロ飲作用を利用した新しい癌悪性化抑制機序の開拓
2018 - 2019 2D,及び3D培養細胞における細胞張力の認知と上皮バリア機能制御
2015 - 2018 A novel tricellular tight junction molecule LSR in diagnosis and therapy for cancer
2016 - 2017 上皮細胞のバリアを超えた過増殖を引き起こすLSRの局在変化と,その機序解明
2013 - 2015 Analysis of the space-occupying process as a novel phenomenon in cell adhesion
2011 - 2012 Occupying the space :A new phenomenon in cell attachment,and the elucidation of molecular mechanism
2009 - 2010 休眠期の癌幹細胞に転移能を与える細胞内シグナルの起源探索
2008 - 2009 カルシウム感受性チロシンキナーゼによる細胞の増殖期と運動期の変換機構の解明
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Papers (77):
Arisa Kura, Kimihito Saito, Takumi Konno, Takayuki Kohno, Hiroshi Shimada, Tadahi Okada, Soshi Nishida, Daichi Ishii, Motoki Matsuura, Tsuyoshi Saito, et al. The roles of tight junction protein cingulin in human endometrioid endometrial cancer. Tissue barriers. 2024. 2361976-2361976
Daichi Ishii, Yuma Shindo, Wataru Arai, Takumi Konno, Takayuki Kohno, Kazuya Honda, Masahiro Miyajima, Atsushi Watanabe, Takashi Kojima. The Roles and Regulatory Mechanisms of Tight Junction Protein Cingulin and Transcription Factor Forkhead Box Protein O1 in Human Lung Adenocarcinoma A549 Cells and Normal Lung Epithelial Cells. International Journal of Molecular Sciences. 2024
Takumi Konno, Takayuki Kohno, Kikuchi S, Kura A, Saito K, Okada T, Shimada H, Yamazaki Y, Sugiyama T, Matsuura M, et al. The interplay between the epithelial permeability barrier, cell migration and mitochondrial metabolism of growth factors and their inhibitors in a human endometrial carcinoma cell line. Tissue barriers. 2024
Shin Kikuchi, Takayuki Kohno, Takashi Kojima, Haruyuki Tatsumi, Yuki Ohsaki, Takafumi Ninomiya. Oxygen-Glucose Deprivation Decreases the Motility and Length of Axonal Mitochondria in Cultured Dorsal Root Ganglion Cells of Rats. Cellular and Molecular Neurobiology. 2023
Wataru Arai, Takumi Konno, Takayuki Kohno, Yuki Kodera, Mitsuhiro Tsujiwaki, Yuma Shindo, Hirofumi Chiba, Masahiro Miyajima, Yuji Sakuma, Atsushi Watanabe, et al. Downregulation of angulin-1/LSR induces malignancy via upregulation of EGF-dependent claudin-2 and TGF-β-dependent cell metabolism in human lung adenocarcinoma A549 cells. Oncotarget. 2023. 14. 261-275
2024/01 - 現在 Sapporo Medical University Department of Cell Science, Institute of Cancer Research Associate Professor
Committee career (1):
2013/12 - 現在 北海道癌談話会 幹事
Awards (4):
2022 - 研究助成(一般) 秋山記念生命科学振興財団
2019 - 優秀演題賞 第51回 日本臨床分子形態学会
2009 - 第36回調査研究助成 大和証券ヘルス財団
2008 - 研究助成(奨励) 秋山記念生命科学振興財団
Association Membership(s) (6):
JAPAN SOCIETY FOR CELL BIOLOGY
, 北海道癌談話会
, THE JAPANESE CANCER ASSOCIATION
, THE MOLECULAR BIOLOGY SOCIETY OF JAPAN
, The Japanese Society of Pathology
, The Japanese Biochemical Society