Research field (8)：
Hygiene and public health (non-laboratory)
, Hygiene and public health (laboratory)
, Healthcare management, medical sociology
, Pharmacology
, Pharmaceuticals - health and biochemistry
, Pathobiochemistry
, Anesthesiology
, Clinical pharmacy
2020 - 2023 Prediction system of risk assessments by change the drug metabolism activity in placenta for pregnancy
2020 - 2023 Systematic identification and characterization of essential drug-metabolizing enzyme toward establishment of platform for drug metabolism research in veterinary species
2019 - 2022 Evaluation for pharmacokinetics of chemicals mediated by flavin-containing monooxygenases using humanized animal models
2017 - 2020 Prediction system of risk assessments by change the drug metabolism activity in placenta for pregnancy
2017 - 2020 Relevance to bioactivation and toxicity of thalidomide, pomalidomide, and lenalidomide by human cytochrome P450 3A enzymes in cultured placental cells and humanized-liver mice
2016 - 2019 Pharmacokinetics prediction of drugs in humans associated with flavin-containing monooxygenase dependent-oxygenations in livers and kidneys of animal models
2017 - 2019 The functional characterization of cytochrome P450 enzymes from preclinical species
2013 - 2018 マーモセットシトクロムP450の網羅的解析
2015 - 2017 The functional chacterization of marmoset cytochrome P450 2C enzymes
2014 - 2017 Evaluaion of Human Cytochrome P450 3A Enzymes in Hepatic and Placental Cells by Thalidomide and Relevance to Bioactivation
2013 - 2016 Drug oxygenations and interactions mediated by polymorphic flavin-containing monooxygenases
2012 - 2015 Quantitative analysis of genetic factors affecting the extent of drug interactions via mechanism based inhibition of cytochrome P450
2012 - 2015 The most suitable administration of antidepressive drug to avoid risk of side effects in patient
2011 - 2013 Thalidomide increases cytochrome P450 activity and drug metabolism in liver through direct activation of nuclear receptor CAR and PXR
2009 - 2011 Drug interaction of thalidomide with midazolam and other compounds : heterotropic cooperativiy of human cyochrome P450
2007 - 2008 Polymorphic drug-metabolizing enzymes of anesthetics agent propofol rekated to its infusion syndrome.
2005 - 2007 Molecular mechanism of chemical-induced toxicity in fetal livers
2003 - 2005 Basic Research for Individualized Medicine
2003 - 2004 Molecular Mechanisms of Toxic Expression Induced by Endocrine Disruptors via AHR
2001 - 2002 In vivo model to predict human fetal toxicity of xenobiotics : Establishment and evaluation of humanized mice carrying multiple forms of human fetal drug metabolizing enzymes.
2000 - 2002 CYP2A6のpharmacogenomics的研究
2000 - 2002 Genetic oncological and molecular epidemiological research on development and progression of the biliary tract cancer in Asia
2000 - 2002 Transcriptional regulation of the CYP3A7 gene specifically expressed in the human fetal liver.
2000 - 2001 Investigation and evaluation of genetic polymorphisms of drug metabolizing
1999 - 2000 PREDICTION OF DRUG DISPOSITION BY HUMAN DRUG METABOLIZING ENZYMES
Enzymology of polymorphic cytochrome P450 and flavin-containing monooxygenase
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Papers (745)：
Ayaka Kojima, Masayuki Nadai, Norie Murayama, Hiroshi Yamazaki, Miki Katoh. Effects of tyrosine kinase inhibitors used for the treatment of non-small cell lung carcinoma on cytochrome P450 2J2 activities. Xenobiotica. 2024
Kana Koinuma, Kenji Noto, Tokio Morita, Yoshinori Uekusa, Haruhisa Kikuchi, Miyuki Shimoji, Hiroyuki Seki, Hiroshi Yamazaki, F. Peter Guengerich, Katsunori Nakamura, et al. Kinetics of the inhibition of CYP3A4 and CYP2C19 activity by jabara juice and identification of the responsible inhibitory components. Journal of pharmaceutical sciences. 2024
Yasuhiro Uno, Kyoko Tsukiyama-Kohara, Mayumi Ishizuka, Hazuki Mizukawa, Norie Murayama, Hiroshi Yamazaki. Investigation of functional cytochrome p450 4A enzymes in liver and kidney of pigs, cats, tree shrews, and dogs in comparison with the metabolic capacity of human p450 4A11. Drug metabolism and disposition. 2024
Makiko Shimizu, Miaki Makiguchi, Yasuhiro Uno, Hiroshi Yamazaki. QuinuclidineN-Oxygenation mediated by flavin-containing monooxygenases 1 and 3 in kidney and liver microsomes from humans, monkeys, dogs, and pigs. Drug metabolism and disposition. 2024
Shotaro Uehara, Norie Murayama, Yuichiro Higuchi, Makiko Shimizu, Hiroshi Suemizu, F. Peter Guengerich, Hiroshi Yamazaki. In vivo and in vitro induction of cytochrome p450 3A4 by thalidomide in humanized-liver mice and experimental human hepatocyte HepaSH cells. Chemical research in toxicology. 2024
Yasuhiro Uno, Makiko Shimizu, Hiroshi Yamazaki. A variety of cytochrome P450 enzymes and flavin-containing monooxygenases in dogs and pigs commonly used as preclinical animal models. Biochemical pharmacology. 2024. 228
安達昂一郎, 清水万紀子, 庄野文章, 船津公人, 山崎浩史. Octanol/water partition coefficients determined in a reverse-phase liquid chromatography as a determinant factor for pharmacokinetic parameter estimations of chemical substances. 日本薬学会年会要旨集(Web). 2024. 144th
村山典恵, 上原正太郎, 上原正太郎, 大山勝宏, 安達昂一郎, 田中庸一, 清水万紀子, 斎藤嘉朗, 山崎浩史. Modeled hepatic exposures of omeprazole prescribed alone in subjects with auto-inducible cytochrome P450 2C19 poor ecpressors likely associated with reported adverse drug events. 日本薬学会年会要旨集(Web). 2024. 144th
佐藤翼, 安達昂一郎, 村山典恵, 清水万紀子, 田中庸一, 斎藤嘉朗, 山崎浩史. Prediction of plasma concentrations of atorvastatin and carbamazepine in subjects harboring cytochrome P450 3A4/5 variants using pharmacokinetic modeling. 日本薬学会年会要旨集(Web). 2023. 143rd
安達昂一郎, 清水万紀子, 田中敏博, 山崎浩史. Pharmacokinetics of acetaminophen in a self-administrated overdose in an adolescent girl. 日本薬学会年会要旨集(Web). 2023. 143rd
2023/02 - International Society of Study of Xenobiotics Asia Pacific Regional Scientific Achievement Award pecies Specificity and Selection of Animal Models for Drug Oxygenations Mediated by Polymorphic Human Enzymes
2014 - 日本薬物動態学会 学会賞
2008 - 日本薬物動態学会Fellow
2005 - 日本薬物動態学会奨励賞
2000 - 日本薬学会奨励賞
Association Membership(s) (4)：
日本臨床薬理学会
, International Society of Study of Xenobiotics
, 日本薬学会
, 日本薬物動態学会
