Research keywords (3)：
分子薬物動態学・臨床薬物動態学
, Clinical Pharmacokinetics
, Molecular Pharmacokinetics
Research theme for competitive and other funds (25)：
2022 - 2025 Urate transporter hunting via functional and clinico-genetic approaches focusing on genetic differences in disuricemia patients between the Japanese and central European
2022 - 2024 Vitamin C research based on vitamin C transporters
2020 - 2024 Studies searching for urate-lowering food components using pharmacokinetic model of urate in the whole body
2020 - 2024 Molecular and epidemiological research on gout and hyperuricemia from Japan: heading toward novel genome-personalized prevention and medicine
2019 - 2021 Elucidation of the whole picture of JR blood type by molecular genetic epidemiological analysis and its application for personalized prevention of gout
2018 - 2021 International collaboration on the research of novel urate transporters by leveraging genetic differences between the Japanese and the Czech
2016 - 2020 Studies searching for functional food components to control novel SUA regulators
2017 - 2019 Searching of hepatoprotective substances in health promotive beverages in terms of the pharmacokinetics and bioactivity
2016 - 2018 Investigation of transport mechanisms of lipid and lipophilic drugs
2015 - 2017 Research on the novel risk of breast cancer focusing of the regulation of endo/exogenous substances in mammary glands
2013 - 2017 Investigation of pathophysiology of gout by molecular genetic epidemiological analysis and application to genome-tailored medicine
2014 - 2016 Investigation of organic solvent-mediated carcinogenic mechanisms of bile duct cancer
2012 - 2016 Basis study for the prediction of fatal DILI risk based on MHC expression in the liver
2011 - 2015 Construction of pharmacokinetic model of urate in the whole body to search for novel pharmacological target(s) of hyperuricemia
2010 - 2015 Analyses of small molecules behaviors in the body which is emerged by the cooperation of multi-organs.
2012 - 2014 Search for key molecules for intestinal virus entry
2009 - 2010 Regulatory mechanisms of sterol transporters under pathophysiological conditions
2007 - 2008 Regulatory mechanisms of sterol transporters in the gut
2006 - 2007 Systematic analysis of intestinal absorption process considering drug transportation across membranes
2006 - 2007 Investigation on the molecular mechanism of NPC1L1-mediated cholesterol uptake
2005 - 2006 OSTα/βの薬物・内因性物質の輸送特性および発現調節機構の解析
2005 - 2006 新規SLC10ファミリートランスポーターの輸送機能および発現調節機構の解析
2005 - 2006 Investigation on the transport mechanism of bile lipids
2001 - 2003 有機アニオン輸送担体の発現調節機構及び遺伝的多型の解析
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Papers (231)：
Tanya J Major, Riku Takei, Hirotaka Matsuo, Megan P Leask, Nicholas A Sumpter, Ruth K Topless, Yuya Shirai, Wei Wang, Murray J Cadzow, Amanda J Phipps-Green, et al. A genome-wide association analysis reveals new pathogenic pathways in gout. Nature genetics. 2024
Tappei Takada, Hiroshi Miyata, Yu Toyoda, Akiyoshi Nakayama, Kimiyoshi Ichida, Hirotaka Matsuo. Regulation of Urate Homeostasis by Membrane Transporters. Gout, Urate, and Crystal Deposition Disease. 2024. 2. 2. 206-219
Yu Toyoda, Tappei Takada, Akiyoshi Nakayama, Nariyoshi Shinomiya, Hirotaka Matsuo. Biochemical characterization of renal hypouricemia-associated mutations in urate transporter genes using human cells. Human cell. 2024
Yu Toyoda, Hirotaka Matsuo, Tappei Takada. Functional characterization of variants in human ABCC11, an axillary osmidrosis risk factor. Human cell. 2024
Blanka Stiburkova, Yu Toyoda, Katerina Pavelcova, Martin Klein, Tappei Takada, Hiroshi Suzuki. Identification and Characterization of a Novel Dysfunction Variant p.I242T in ABCG2 Transporter in a Family with Early-onset Hyperuricamia and Gout. ARTHRITIS & RHEUMATOLOGY. 2019. 71
