Rchr
J-GLOBAL ID：200901033490787350
Update date: Jun. 06, 2024
Mashima Tetsuo
マシマ テツオ | Mashima Tetsuo
Affiliation and department：
Job title：
Researcher
Homepage URL (1)：
https://scholar.google.com/citations?user=Yq7ZvtsAAAAJ&hl=en
Research field (1)：
Molecular biology
Research keywords (4)：
分子標的治療
, 癌
, Molecular-Target Therapy
, Cancer
Research theme for competitive and other funds (24)：
- 2022 - 2028 先端モデル動物支援プラットフォーム
- 2021 - 2024 大腸癌治療薬の基礎解析データからの血中循環バイオマーカー同定と生物学的意義の解析
- 2021 - 2024 胃がんの初期薬剤抵抗性を司るがん細胞の可塑性および安定維持機構の解明
- 2022 - 分子プロファイリング支援活動・トランスクリプトーム解析
- 2019 - 2022 Changes in the immunological profile of gastric cancer stem cells due to irradiation
- 2016 - 2022 Development of innovative methods for cancer therapy based on DDS
- 2018 - 2021 Analysis of the regulation mechanisms of colorectal cancer stem cell maintenance and plasticity
- 2016 - 2019 Synthetic lethality-based identification of drug-sensitive genome profiles
- 2015 - 2018 Identification of biomarkers for novel therapeutic agents in colorectal cancer based on preclinical analysis.
- 2015 - 2018 Clinical impact of intratumoral HER2 heterogeneity on trastuzumab eficacy
- 2014 - 2017 Analysis of the mechanisms of survival and differentiation inhibition of prostate tumor-propagating cells
- 2010 - 2016 Scientific Support Programs for Cancer Research Grant-in-Aid for Scientific Research on Innovative Areas
- 2011 - 2013 Role of oncogenic factors and their cooperations in survival of prostate tumor-propagating cells
- 2010 - 2011 Lipid metabolomics to analyze the mechanisms for cellular adaptation to tumor microenvironment
- 2005 - 2009 Molecular therapeutics targeting drug-resistance mechanisms
- 2006 - 2007 脂質代謝制御系を標的とした難治がん選択的治療法の開発
- 2006 - 2007 アポトソーム選択的活性化化合物を用いた細胞死制御因子同定と癌治療
- 2003 - 2005 アポトーシス実行に関わるアポトソーム系制御因子の同定
- 2001 - 2004 癌細胞の内在性アポトーシス阻害因子とこれを標的とした抗腫瘍薬剤の探索
- 2001 - 2002 アポトーシス実行に関わるApaf1およびCARD4を制御する新たな蛋白質の同定
- 2000 - 2000 癌細胞のアポトーシス誘導制御因子を標的とする化合物を用いた新しい癌化学療法の開発
- 1999 - 1999 抗癌剤による癌細胞のアポトーシスにおける転写誘導遺伝子の同定とその機能の解析
- 1994 - 1999 がん細胞の薬剤感受性と抵抗性の分子機構とその制御
- Development of novel reprogramming therapy with tankyrase inhibitors by dual targeting of cancer microenvironment and stemness
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Papers (76)：
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Ayane Nakamura, Tetsuo Mashima, Jin Lee, Saori Inaba, Naomi Kawata, Shun Morino, Koshi Kumagai, Kensei Yamaguchi, Hiroyuki Seimiya. Intratumor transforming growth factor-β signaling with extracellular matrix-related gene regulation marks chemotherapy-resistant gastric cancer. Biochemical and biophysical research communications. 2024. 721. 150108-150108
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Jin Lee, Tetsuo Mashima, Naomi Kawata, Noriko Yamamoto, Shun Morino, Saori Inaba, Ayane Nakamura, Koshi Kumagai, Takeru Wakatsuki, Kengo Takeuchi, et al. Pharmacological targeting of histone H3K27 acetylation/BRD4-dependent induction of ALDH1A3 for early-phase drug tolerance of gastric cancer. Cancer research communications. 2024
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Shiho Hirose, Tetsuo Mashima, Xunmei Yuan, Makiko Yamashita, Shigehisa Kitano, Shinichi Torii, Toshiro Migita, Hiroyuki Seimiya. Interleukin-4 induced 1-mediated resistance to an immune checkpoint inhibitor through suppression of CD8+ T cell infiltration in melanoma. Cancer Science. 2024
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Shun Morino, Tetsuo Mashima, Fumiyuki Shirai, Satoshi Nagayama, Ryohei Katayama, Hiroyuki Seimiya. BET protein-dependent E2F pathway activity confers bell-shaped type resistance to tankyrase inhibitors in APC-mutated colorectal cancer. Cancer letters. 2024. 584. 216632-216632
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Mingjue Chen, Tetsuo Mashima, Taichi Oishi, Yukiko Muramatsu, Yosuke Seto, Manabu Takamatsu, Naomi Kawata, Shun Morino, Ayane Nakamura, Saori Inaba, et al. APC/PIK3CA mutations and β-catenin status predict tankyrase inhibitor sensitivity of patient-derived colorectal cancer cells. British journal of cancer. 2023
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MISC (39)：
Patents (5)：
Education (4)：
- - 1997 The University of Tokyo
- - 1997 The University of Tokyo Graduate School, Division of Pharmaceutical Sciences
- - 1992 The University of Tokyo Faculty of Pharmaceutical Sciences
- - 1992 The University of Tokyo Faculty of Pharmaceutical Science
Professional career (1)：
Committee career (4)：
- JFCR-ISCC Symposium Committee Member
- 日本癌分子標的治療学会 選挙管理委員
- 日本癌分子標的治療学会 評議員
- 日本癌学会 評議員
Awards (2)：
- 2007 - 日本がん分子標的治療学会研究奨励賞
- 2007 - 日本癌学会奨励賞
Association Membership(s) (4)：
日本分子標的治療学会
, 日本分子生物学会
, 日本癌学会
, 日本薬学会
