Rchr
J-GLOBAL ID：200901034604344514   Update date: Apr. 02, 2024

Kaifu Tomonori

カイフ トモノリ | Kaifu Tomonori
Affiliation and department：
Tohoku Medical and Pharmaceutical University

About Tohoku Medical and Pharmaceutical University


Job title： Associate Professor
Homepage URL  (1)： http://www.tohoku-mpu.ac.jp/medicine/about/immunology/
Research field  (2)： Immunology ,  Laboratory animal science
Research keywords  (6)： 糖鎖 ,  cytokine ,  osteoclasts ,  osteoimmunology ,  C-type lectin receptor ,  autoimmune disease
Research theme for competitive and other funds  (11)：
  • 2022 - 2025 自然免疫受容体DCIRを標的とした自己免疫、炎症性疾患治療の試み
  • 2022 - 2025 The project that elucidates the mechanism of immunological homeostasis by modification of terminal sugar structure
  • 2019 - 2022 糖鎖認識受容体DCIRと糖鎖リガンドの相互作用による免疫応答制御の解明
  • 2016 - 2021 糖鎖分子による自然免疫受容体制御を介した免疫・骨代謝異常 治療法の開発
  • 2012 - 2017 Establishment of an IL-1-related gene-manipulated mouse library and dissection of the gene-targeted mice, aiming at identifying new therapeutic targets for diseases
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Papers (36)：
  • Atsuya Sawabe, Shogo Okazaki, Akira Nakamura, Ryo Goitsuka, Tomonori Kaifu. The orphan G protein-coupled receptor 141 expressed in myeloid cells functions as an inflammation suppressor. Journal of leukocyte biology. 2024
  • Kazuya Takeda, Tomonori Kaifu, Ryunosuke Michihata, Naotaka Kinugawa, Atushi Fujioka, Ayaka Tateno, Kaoru Toshima, Hirotaka Kanoh, Kei-Ichiro Inamori, Keiju Kamijo, et al. Chronic encephalomyelitis virus exhibits cellular tropism and evades pDCs by binding to sialylated integrins as the cell surface receptors. European journal of immunology. 2023. e2350452
  • Tomonori Kaifu, Takumi Maruhashi, Soo-Hyun Chung, Kenji Shimizu, Akira Nakamura, Yoichiro Iwakura. DCIR suppresses osteoclastic proliferation and resorption by downregulating M-CSF and RANKL signaling. Frontiers in Immunology. 2023. 14. 1159058-1159058
  • Yuki Kohada, Akito Kuromoto, Kazuya Takeda, Hiromichi Iwamura, Yuri Atobe, Jun Ito, Tomonori Kaifu, Yasuhiro Kaiho, Ichiro Nakashima, Nobuyuki Hinata, et al. Circulating PMN-MDSC level positively correlates with a poor prognosis in patients with metastatic hormone-sensitive prostate cancer. Frontiers in Urology. 2022. 2
  • Yulia Makusheva, Soo-Hyun Chung, Aoi Akitsu, Natsumi Maeda, Takumi Maruhashi, Xiao-Qi Ye, Tomonori Kaifu, Shinobu Saijo, Haiyang Sun, Wei Han, et al. The C-type lectin receptor Clec1A plays an important role in the development of experimental autoimmune encephalomyelitis by enhancing antigen presenting ability of dendritic cells and inducing inflammatory cytokine IL-17. Experimental animals. 2022
ｍore...
MISC (26)：
  • 武田和也, 姫田敏樹, 海部知則, 大原義朗, 中村晃. Comparison of glycolipids and N-glycans between Theiler’s murine encephalomyelitis virus binding and non-binding cells. 日本ウイルス学会学術集会プログラム・予稿集(Web). 2021. 68th
  • 武田和也, 海部知則, 中村晃. タイラーマウス脳脊髄炎ウイルス受容体機能に関与する糖脂質の解析. Neuroimmunology. 2021. 26. 1
  • 吉村成央, 海部知則, 武田和也, 跡部百合, 佐々木高信, 菅原崇史, 大類孝, 中村晃. Dynamic alteration of peripheral immune cells in patients with advanced NSCLC received anti-PD-1 therapy and clinical efficacy. 日本呼吸器学会誌(Web). 2021. 10
  • 澤邊敦哉, 中村晃, 後飯塚僚, 海部知則. 自己免疫疾患におけるGタンパク質共役型受容体の機能解析. 日本インターフェロン・サイトカイン学会学術集会抄録集. 2021. 85th (CD-ROM)
  • 海部知則, 武田和也, 岩倉洋一郎, 中村晃. C型レクチン受容体欠損による中枢神経系自己免疫疾患自然発症機序の解明. 日本実験動物学会総会講演要旨集(Web). 2020. 67th
ｍore...
Patents (2)：
Books (3)：
  • C-Type Lectin Receptors in Immunity
    Springer Japan 2016
  • サイトカイン・増殖因子キーワード事典
    羊土社 2015
  • 炎症性サイトカインと骨破壊
    医学のあゆみ 2014
Lectures and oral presentations  (4)：
  • Modification of terminal sugar moiety by neuraminidase regulates immune responses
    (The 2nd TMPU-Acadamia Sinica Joint Symposium 2023)
  • DCIR, a carbohydrate-recognizing inhibitory C-type lectin receptor, regulate the immune system and bone metabolism.
    (2022)
  • Modification of terminal sugar moiety regulates osteoclastogenesis and immune responses.
    (JSICR/MMCB 2022 Joint Symposium 2022)
  • A glycosylation enzyme ameliorates experimental autoimmune encephalomyelitis through increasing ligand for an inhibitory C-type lectin receptor.
    (Novel Pain Therapeutics 2019)
Professional career (1)：
  • 医学博士 (東北大学)
Work history (7)：
  • 2024/04 - 現在 Tohoku Medical and Pharmaceutical University Faculty of Medicine, Division of Immunology Associate Professor
  • 2016/04 - 2024/03 Tohoku Medical and Pharmaceutical University Faculty of Medicine, Division of Immunology
  • 2012/04 - 2016/03 Tokyo University of Science Research Institute for Biological Sciences
  • 2010/04 - 2012/03 The University of Tokyo
  • 2009/12 - 2010/03 The University of Tokyo
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Committee career (4)：
  • 2018/06 - 現在 Experimental Animals 編集委員
  • 2018/06 - 現在 日本実験動物学会 評議員
  • 2015/12 - 現在 日仏生物学会 総務幹事
  • 2015/04 - 2015/12 第80回(2015年度)日本インターフェロン・サイトカイン学会学術集会 実行委員
Awards (4)：
  • 2023/05 - Best paper award in 2022 Experimental Animals The C-type lectin receptor Clec1A plays an important role in the development of experimental autoimmune encephalomyelitis by enhancing antigen presenting ability of dendritic cells and inducing inflammatory cytokine IL-17.
  • 2018/06 - 日本骨免疫学会 優秀演題賞 抑制型C型レクチン受容体(DCIR)による破骨細胞制御機構
  • 2016/11 - 日仏生物学会 ベストプレゼンテーション賞 C型レクチン受容体DCIRの機能的リガンドの同定
  • 2006/04 - 上原記念生命科学財団 リサーチフェローシップ
Association Membership(s) (4)：
Societe Franco-Japonaise de Biologie ,  THE JAPANESE SOCIETY FOR IMMUNOLOGY ,  JAPANESE ASSOCIATION FOR LABORATORY ANIMAL SCIENCE ,  日本神経免疫学会
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