Nakano Masakazu

ナカノマサカズ | Nakano Masakazu

Affiliation and department：
Job title： Assistant Professor

Research field (1)： Pathobiochemistry

Research keywords (2)：ゲノム医科学 , 分子生物学

Research theme for competitive and other funds (20)：

2024 - 2027 Identification of novel target molecules against ALL and discovery of their seed compounds using open access data
2023 - 2026 Investigation of genetic variants and clinical risk factors associated with the progression rate of visual field defect in glaucoma
2021 - 2024 Establishing a Risk Prediction Method for Primary Open Angle Glaucoma Using Next Generation Sequencer and Analysis on Non-synonymous Valiant
2021 - 2024 Establishment of multi-omics dataset for elucidating the genetic factors of corneal dystrophy
2020 - 2023 遺伝解析の統計的検出力を高めるための緑内障臨床情報クラスタリング手法の開発

2020 - 2023 Identification and kinetic analysis of glaucoma resistance gene with primary open angle glaucoma

2020 - 2023 疾患関連ゲノム領域に潜む人種差から迫る緑内障発症機序解明に向けたマルチオミクス

2017 - 2020 Evaluation of genetic factors for deterioration of primary open angle glaucoma

2017 - 2020 Identification of variants associated with intraocular pressure lowering efficacy of glaucoma eye drops by genome-wide association study

2017 - 2020 Identification of responsible genomic region of Primary Open Angle Glaucoma with International Consortium

2015 - 2018 The effect of TGC triplet repeat expansion on the pathophysiology of Fuchs endothelial corneal dystrophy

2014 - 2017 Identifying novel angiogenesis-related pathway from differentially expressed genes during retinal development obtained by the microarray analysis

2014 - 2017 Genome wide association study by visual field defect pattern in primary open angle glaucoma

2014 - 2017 Revealing pathogenesis of Fuchs endothelial corneal dystrophy in Japanese by means of exome array

2012 - 2015 Candidate gene analysis of well-known genes in primary open-angle glaucoma patients utilizing custom-made gene chip

2012 - 2014 Resequencing analysis of glaucoma-associated chromosome loci

2011 - 2013 Identification of Japanese-specific SNP in exfoliation glaucoma patients with genome-wide association analysis of 1000K microarray

2011 - 2012 落屑緑内障の発症機序解明と分子診断を目指したゲノム医科学研究のための生体試料の収集と臨床情報のデータベース化

2010 - 2011 Analyzing glaucoma-associated variants to reveal molecular mechanism of glaucoma pathogenesis

2002 - 2003 がん治療を目指した単一型特異的高度発現アデノウイルスベクターの開発

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Papers (62)：

Tetsuro Honda, Tatsuya Nakagawa, Taichi Yuasa, Yuichi Tokuda, Masakazu Nakano, Kei Tashiro, Theofilos Tourtas, Ursula Schlötzer-Schrehardt, Friedrich Kruse, Koji Yamamoto, et al. Dysregulation of the TCF4 Isoform in Corneal Endothelial Cells of Patients With Fuchs Endothelial Corneal Dystrophy. Investigative ophthalmology & visual science. 2024. 65. 6. 27-27
Yasuo Takashima, Tohru Inaba, Tasuku Matsuyama, Kengo Yoshii, Masami Tanaka, Kazumichi Matsumoto, Kazuki Sudo, Yuichi Tokuda, Natsue Omi, Masakazu Nakano, et al. Potential marker subset of blood-circulating cytokines on hematopoietic progenitor-to-Th1 pathway in COVID-19. Frontiers in Medicine. 2024. 11
Yuka Kawaji-Kanayama, Taku Tsukamoto, Masakazu Nakano, Yuichi Tokuda, Hiroaki Nagata, Kentaro Mizuhara, Yoko Katsuragawa-Taminishi, Reiko Isa, Takahiro Fujino, Yayoi Matsumura-Kimoto, et al. miR-17-92 cluster-BTG2 axis regulates B-cell receptor signaling in mantle cell lymphoma. Cancer science. 2023
Yuki Sugiyama, Seikou Nakamura, Yuichi Tokuda, Masakazu Nakano, Yasunao Hattori, Hiroki Nishiguchi, Yuki Toda, Shigekuni Hosogi, Masayuki Yamashita, Kei Tashiro, et al. 7,8-Dihydroxy-3-(4'-hydroxyphenyl)coumarin inhibits invasion and migration of osteosarcoma cells. Biochemical and biophysical research communications. 2022. 638. 200-209
Tatsuya Nakagawa, Yuichi Tokuda, Masakazu Nakano, Yuya Komori, Naoya Hanada, Theofilos Tourtas, Ursula Schlötzer-Schrehardt, Friedrich Kruse, Kei Tashiro, Noriko Koizumi, et al. RNA-Seq-Based Transcriptome Analysis of Corneal Endothelial Cells Derived from Patients with Fuchs Endothelial Corneal Dystrophy. Scientific reports. 2022. 13. 1. 8647-8647

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MISC (30)：

湯淺太智, 奥村直毅, 中川達也, 本田徹郎, 立石あやな, SCHLOETZER-SCHREHARDT Ursula, KRUSE Friedrich, 徳田雄市, 中野正和, 小泉範子. フックス角膜内皮ジストロフィにおけるTCF4のスプライシング異常の検討. 日本角膜学会総会・日本角膜移植学会プログラム・抄録集. 2024. 48th-40th
島田虎太朗, 奥村直毅, 今井康太, 中川達也, 立石あやな, SCHLOTZER-SCHREHARDT Ursula, KRUSE Friedrich, 徳田雄市, 中野正和, 小泉範子. フックス角膜内皮ジストロフィ患者の角膜内皮における長鎖非コードRNAの解析. 日本角膜学会総会・日本角膜移植学会プログラム・抄録集. 2024. 48th-40th
徳田雄市, 奥拓明, 中山知倫, 渡辺彰英, 外園千恵, 田代啓, 中野正和. Optimization of nucleic acid extraction methods from tissues for obtaining high-quality genomic analysis data. 日本分子生物学会年会プログラム・要旨集(Web). 2023. 46th
立石あやな, 奥村直毅, 中川達也, 小森裕也, 花田尚也, 徳田雄市, 中野正和, 小泉範子. Transcriptome Analysis of Human Corneal Endothelial Cells between Sexes. 日本角膜学会総会・日本角膜移植学会プログラム・抄録集. 2023. 47th-39th
本田徹郎, 奥村直毅, 中川達也, 立石あやな, 山本浩司, SCHBETZER-SCHREDHARDT Ursula, KRUSE Friedrich, 徳田雄市, 中野正和, 小泉範子. RNA-Seq Analysis of Altered TCF4 Isoforms in Fuchs Endothelial Corneal Dystrophy. 日本角膜学会総会・日本角膜移植学会プログラム・抄録集. 2023. 47th-39th

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Lectures and oral presentations (17)：

遺伝医学と次世代シーケンサーの進化
(第102回TIK(Team In KYOTO)勉強会 2023)
Genetics study of common diseases toward revealing the molecular pathogenesis.
(Symposia KPUM 2022)
Genetics study of common diseases - from statistical significance to functional annotation -.
(Symposia KPUM 2020)
大規模データを活用した多因子疾患のゲノム医科学研究
(第22回スクリプス・バイオメディカルフォーラム 2019)
Genetics study of exfoliation syndrome/exfoliation glaucoma in Japanese
(2019)

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Professional career (1)：

博士(工学) (東京理科大学)

Work history (10)：

2013/04 - 現在 Kyoto Prefectural University of Medicine
2014/07 - 2019/03 Doshisha University
2010/04 - 2013/03 Kyoto Prefectural University of Medicine
2009/08 - 2010/03 Division of Genome Information Sciences, Moores UCSD Cancer Center, University of California, San Diego,
2008/04 - 2009/07 Scripps Genomic Medicine, The Scripps Research Institute,

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Association Membership(s) (3)：

American Society of Human Genetics , 日本生化学会 , 日本分子生物学会

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