Rchr
J-GLOBAL ID:200901034996543072   Update date: Jan. 08, 2020

KANEKO Masayuki

カネコ マサユキ | KANEKO Masayuki
Affiliation and department:
Job title: Associate Professor
Homepage URL  (2): http://home.hiroshima-u.ac.jp/imaizumi/index.htmlhttp://www.cis.ac.jp/~kyoin_info/PL/mkaneko.html
Research field  (2): Pharmacology in pharmacy ,  Neurochemistry/Neuropharmacology
Research keywords  (19): osmolality ,  lysosome ,  genome editing ,  apoptosis ,  brain ischemia ,  bioinformatics ,  chemical chaperone ,  ubiquitin ,  Parkinson's disease ,  Alzheimer's disease ,  ubiquitin ligase ,  ERAD ,  Neurodegenerative disease ,  ER stress ,  ALS ,  APP ,  Stress Response ,  Neurodegenerative Diseases ,  Signal Transduction
Research theme for competitive and other funds  (3):
  • 2007 - 2008 The inhibitory mechanism of novel proteins induced in the endoplasmic reticulum and of drugs on neurodegenerative diseases
  • 2007 - 2008 Identification and characterization of genes involved in endoplasmic reticulum-associated degradation
  • 2003 - 2006 Studies on the Regulatory Mechanism of Neuronal Death: Isolation of Novel Factors and Title of Preparation of Model of Neurodegenerative Disease.
Papers (57):
  • Okamoto T, Wu Y, Matsuhisa K, Saito A, Sakaue F, Imaizumi K, Kaneko M. Hypertonicity-responsive ubiquitin ligase RNF183 promotes Na, K-ATPase lysosomal degradation through ubiquitination of its β1 subunit. Biochemical and biophysical research communications. 2020. 521. 4. 1030-1035
  • Wu Y, Kimura Y, Okamoto T, Matsuhisa K, Asada R, Saito A, Sakaue F, Imaizumi K, Kaneko M. Inflammatory bowel disease-associated ubiquitin ligase RNF183 promotes lysosomal degradation of DR5 and TRAIL-induced caspase activation. Scientific reports. 2019. 9. 1. 20301
  • Sekine SI, Kaneko M, Tanaka M, Ninomiya Y, Kurita H, Inden M, Yamada M, Hayashi Y, Inuzuka T, Mitsui J, Ishiura H, Iwata A, Fujigasaki H, Tamaki H, Tamaki R, Kito S, Taguchi Y, Tanaka K, Atsuta N, Sobue G, Kondo T, Inoue H, Tsuji S, Hozumi I. Functional evaluation of PDGFB-variants in idiopathic basal ganglia calcification, using patient-derived iPS cells. Scientific Reports. 2019. 9. 1. 5698
  • Yosuke Osaki, Koji Matsuhisa, Wang Che, Masayuki Kaneko, Rie Asada, Takao Masaki, Kazunori Imaizumi, Atsushi Saito. Calnexin promotes the folding of mutant iduronate 2-sulfatase related to mucopolysaccharidosis type II. Biochemical and Biophysical Research Communications. 2019. 514. 1. 217-223
  • Maeoka Y, Okamoto T, Wu Y, Saito A, Asada R, Matsuhisa K, Terao M, Takada S, Masaki T, Imaizumi K, Kaneko M. Renal medullary tonicity regulates RNF183 expression in the collecting ducts via NFAT5. Biochemical and biophysical research communications. 2019. 514. 2. 436-442
more...
MISC (16):
Lectures and oral presentations  (28):
  • 神経保護作用を持つストレス応答分子
    (日本薬学会第121年会 2001)
  • ERAD(小胞体関連分解)関連分子Hrd1pのヒトホモログの単離・同定とその機能・誘導機構の解析
    (第45回神経化学会大会 2002)
  • ERAD(小体関連分解)関連分子HRD1, SEL1Lの小胞体ストレスに対する防御機構の解析
    (第75回日本生化学会大会 2002)
  • ER signaling in unfolded protein response and drug action
    (The 4th International Symposium on Receptor Mechanisms, Signal Transduction and Drug Effects 2003)
  • 哺乳類におけるERAD遺伝子の誘導機構と小胞体ストレス防御作用
    (第5回ファーマサイエンスフォーラム 2003)
more...
Education (3):
  • 1994 - 1995 Hokkaido University
  • 1995 - 1998 Hokkaido University Faculty of Pharmaceutical Sciences
  • 1998 - 2000 Hokkaido University Graduate School of Pharmaceutical Sciences
Professional career (1):
  • Doctor (Hokkaido University)
Work history (5):
  • 2000/07 - 2005/03 Hokkaido University Research Associate
  • 2005/04 - 2011/03 Chiba Institute of Science Lecturer
  • 2011/04 - 2012/05 Chiba Institute of Science Associate Professor
  • 2012/06 - 2014/06 Gifu Pharmaceutical University Lecturer
  • 2014/07 - 現在 Graduate School of Biomedical & Health Sciences, Hiroshima University Associate Professor
Association Membership(s) (7):
The Pharmaceutical Society of Japan ,  The Japanese Pharmacological Society ,  Japanese Society for Neurochemistry ,  The Japan Brain Science Society ,  The Japanese Biochemical Society ,  The Council for SAM Research ,  Society for Neuroscience
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