Research theme for competitive and other funds (5)：
2017 - 2020 Involvement of acyl-CoA thioester metabolite in drug-induced idiosyncratic liver injury
2017 - 2020 特異体質性肝障害にアシルCoAチオエステル中間代謝物は関与しているか?
2011 - 2014 反応性代謝物を介する肝障害発現に関与する機能タンパク質の解明
2008 - 2010 Development of an adenovirus vector containing microRNA-regulated gene expression system
1992 - 1993 PERCUTANEOUS ABSORPTION OF PEPTIDE DRUGS AND THE APPLICATION FOR MEDICAL TREATMENT
Papers (241)：
Hiroaki Shimada, Akito Yokotobi, Nonoka Yamamoto, Mao Takada, Atsushi Kawase, Takeo Nakanishi, Masahiro Iwaki. Inhibition of 15-prostaglandin dehydrogenase attenuates acetaminophen-induced liver injury via suppression of apoptosis in liver endothelial cells. Prostaglandins, leukotrienes, and essential fatty acids. 2024. 202. 102640-102640
Yoshihito Kasanami, Takashi Yamamoto, Tomoyoshi Miyamoto, Sumio Matzno, Mikio Sakakibara, Masahiro Iwaki, Atsufumi Kawabata. Characterization of Potentially Inappropriate Medications That Need Special Attention in the Elderly with Dementia by Analyzing Pharmacy Claims Data. Biological and Pharmaceutical Bulletin. 2023. 46. 12. 1699-1705
Atsushi Kawase, Kota Irie, Naoya Matsuda, Yuzuki Takai, Hiroaki Shimada, Masahiro Iwaki. Distinct roles of HMGB1 in the regulation of P-glycoprotein expression in the liver and kidney of mice with lipopolysaccharide-induced inflammation. Molecular medicine reports. 2022. 26. 5
Hiroyuki Ikuta, Hiroaki Shimada, Kenjiro Sakamoto, Rena Nakamura, Atsushi Kawase, Masahiro Iwaki. Species differences in liver microsomal hydrolysis of acyl glucuronide in humans and rats. Xenobiotica. 2022. 52. 7. 1-8
Atsushi Kawase, Ouka Takashima, Satsuki Tanaka, Hiroaki Shimada, Masahiro Iwaki. Diclofenac-Induced Cytotoxicity in Direct and Indirect Co-Culture of HepG2 Cells with Differentiated THP-1 Cells. International journal of molecular sciences. 2022. 23. 15
Effects of Mrp2- and Mrp3-knockdown in mice on covalent adduct formation of acyl glucuronide using shRNA-expressing adenovirus vector
(Pharmaceutical Sciences World Congress 2010 2010)
The effect of fasting and hyperlipidemia on the disposition of pravastatin in the in situ perfused rat liver model
(Pharmaceutical Sciences World Congress 2010 2010)
