Yotsuyanagi Hiroshi

ヨツヤナギヒロシ | Yotsuyanagi Hiroshi

Affiliation and department：
Job title：教授

Research field (1)： Infectious disease

Research theme for competitive and other funds (27)：

2024 - 2027 移植摘出肝に着眼したB型肝癌のクローナリティ解析ーゲノム個別化治療の基盤構築
2023 - 2026 高齢HIV感染者の生活習慣病に関するヘルスリテラシーの研究
2022 - 2025 進行性前立腺癌における免疫環境の解明と新規CAR-T細胞による免疫療法の開発
2022 - 2025 Genomic analysis of hepatitis-B-related hepatocarcinoma developing after administration of nucleoside acid analogue - revealing the mechanism and its clinical application
2021 - 2024 Hepatitis B vaccination for immunocompromised hosts

2015 - 2018 Elucidation of the mechanism of cryoglobulin formation in hepatitis C

2011 - 2013 Analysis of the role of HBx in the HBV-related hepatocarninogenesis

2008 - 2010 Control of chronic hepatitis by splicing variant of hepatitis B virus

2008 - 2010 Metabolic abnormalities in hepatitis C and its impact on the progression of liver disease

2006 - 2007 C型肝炎ウイルスRNAのマイクロ断片化によるウイルス増殖制御法の開発

2006 - 2007 Hepatitis C as a Metabolic Disease : Pathogenesis for liver cancer and lifestyle-related diseases

2006 - 2007 C型肝炎ウイルスによる肝発癌機構の解明

2005 - 2005 HIV感染によるC型慢性肝炎進行促進機序の解明

1999 - 2000 ANALYSIS OF HEPATITIS B VIREMIA AMONG HBS ANTIGEN-NEGATIVE PEOPLE (MUTUAL REACTION BETWEEN HBV AND CYTOTOXIC T CELLS)

1998 - 1998 トランスジェニックマウスを用いたC型肝炎ウイルスによる肝発癌機構の解明

1997 - 1998 Investigation for the development of vaccine against hepatitis C virus

1997 - 1997 トランスジェニックマウスを用いたC型肝炎ウイルスによる肝発癌機構の解明

1996 - 1997 DEVELOPMENT OF HEPATITIS THERAPY AND VACCINE USING HEPATITIS C VIRUS TRANSGENIC MICE

1994 - 1995 Transgenic mice carrying hepatitis C Virus genome

1994 - 1994 C型肝炎ウイルスコア蛋白の細胞同期進行中の細胞内局在の変化とその肝発癌への関与

1993 - 1993 B型肝炎ウイルスX遺伝子の肝発癌における細胞周期促進とアポトーシス誘発作用の解析

1993 - 1993 トランスジェニックマウスを用いたB型肝炎ウイルスX遺伝子による肝発癌機構の解析

1990 - 1991 TRANSGENIC MOUSE MODEL FOR GASTRIC AND HEPATOCELLULAR CARCINOMA

肝発癌に関する研究

ウイルス肝炎に関する研究

Study on Hepatocarcinogenesis

Study on viral Hepatitis

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Papers (466)：

Yukari Inoue, Akiyo Ishiguro, Yutaka Suehiro, Yuki Kunimune, Yuko Yamaoka, Shinichi Hashimoto, Katsuhiko Nakamura, Atsushi Goto, Koichi Hamabe, Toshihiko Matsumoto, et al. A novel index combining fecal immunochemical test, DNA test, and age improves detection of advanced colorectal adenoma. Cancer science. 2024. 115. 11. 3682-3694
Tetsuya Kuwano, Takayuki Kanno, Minoru Tobiume, Yuichiro Hirata, Harutaka Katano, Michiko Koga, Hiroyuki Nagai, Takeya Tsutsumi, Noritada Yoshikawa, Hiroshi Yotsuyanagi, et al. Non-invasive SARS-CoV-2 RNA detection and human transcriptome analysis using skin surface lipids. Scientific reports. 2024. 14. 1. 26057-26057
Wakana Sato, Ayako Sedohara, Michiko Koga, Yu Nakagama, Hiroshi Yotsuyanagi, Yasutoshi Kido, Eisuke Adachi. Epidemic of multiple Treponema pallidum strains in men who have sex with men in Japan: efficient multi-locus sequence typing scheme and indicator biomarkers. AIDS research and therapy. 2024. 21. 1. 71-71
Kazuya Okushin, Tatsuya Kanto, Masaaki Korenaga, Kazuhiko Ikeuchi, Toshiyuki Kishida, Akira Kado, Mitsuhiro Fujishiro, Takeya Tsutsumi, Tomoyuki Takura, Hiroshi Yotsuyanagi. Real-world trends in acute viral hepatitis in Japan: A nationwide questionnaire-based survey. Hepatology research : the official journal of the Japan Society of Hepatology. 2024
Aya Ishizaka, Michiko Koga, Taketoshi Mizutani, Yutaka Suzuki, Tetsuro Matano, Hiroshi Yotsuyanagi. Thiamine deficiency underlies persistent gut dysbiosis and inflammation in people living with HIV on antiretroviral therapy. Translational Medicine Communications. 2024. 9. 1

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MISC (132)：

水谷壮利, 石坂彩, 古賀道子, 山吉誠也, 山吉誠也, 岩附研子, 安達英輔, 鈴木穣, 河岡義裕, 河岡義裕, et al. SARS-CoV-2感染がPLWHに及ぼす腸内細菌叢変化と病態との相関関係. 日本エイズ学会誌. 2023. 25. 4
石坂彩, 古賀道子, 水谷壮利, 四柳宏, 四柳宏. HIV感染者における腸内細菌叢の時間変化と体重増加の関係. 日本エイズ学会誌. 2023. 25. 4
Akira Kado, Takeya Tsutsumi, Kazuya Okushin, Hidetaka Fujinaga, Kyoji Moriya, Hiroshi Yotsuyanagi, Kazuhiko Koike, Mitsuhiro Fujishiro. DIFFERENCES OF PERIPHERAL MEMORY T CELL SUBSETS IN LIVER FIBROSIS AND PATHOLOGICAL PROGRESSION OF NONALCOHOLIC FATTY LIVER DISEASE. HEPATOLOGY. 2022. 76. S655-S656
Eisuke Adachi, Makoto Saito, Hiroyuki Nagai, Kazuhiko Ikeuchi, Michiko Koga, Takeya Tsutsumi, Hiroshi Yotsuyanagi. Transient depletion of T cells during COVID-19 and seasonal influenza in people living with HIV. JOURNAL OF MEDICAL VIROLOGY. 2022
Hideaki Takahashi, Chiaki Okuse, Norie Yamada, Takeshi Niinuma, Masahiro Kai, Hideki Wakasugi, Noriyuki Akutsu, Hiroshi Yotsuyanagi, Michihiro Suzuki, Hiromu Suzuki, et al. LOW EXPRESSION OF miRNA-199-5p AND miRNA-374 CAN PREDICT THE INCIDENCE OF HEPATOCELLULAR CARCINOMA IN PATIENTS WITH CHRONIC HEPATITIS B AFTER ADMINISTRATION OF NUCLEOSIDE ANALOG. HEPATOLOGY. 2021. 74. 656A-657A

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Education (4)：

2016 - 現在東京大学医科学研究所
2004 - 2016 The University of Tokyo
1998 - 2004 聖マリアンナ医科大学
1986 - 1998 The University of Tokyo Faculty of Medicine

Professional career (1)：

(BLANK) (The University of Tokyo)

Committee career (4)：

2023/04 - 現在日本内科学会理事
2021/08 - 現在日本環境感染学会理事
2020/09 - 現在日本肝臓学会理事
2019/04 - 現在日本感染症学会理事

Awards (1)：

1995 - 日本肝臓学会奨励賞

Association Membership(s) (8)：

日本感染症学会 , 日本癌学会 , 日本内科学会 , 日本消化器病学会 , 日本肝臓学会 , 日本環境感染学会 , 日本エイズ学会 , 日本性感染症学会

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