2020 - 2023 Basis of treatment strategy for type 2 diabetes using new indices obtained by visualization of pancreatic beta cell activities in vivo
2015 - 2018 Screening and analysis of glial factors for neuroprotection
2015 - 2018 Project to create international glial researcher network: mainly focusing on Japan-Germany research exchange
2013 - 2017 Calcium-dependent regulation and pathophysiology of central nervous system network
2013 - 2017 Analysis of glia-assembly by visualization and control of calcium signal
2009 - 2013 Imaging analyses of signaling mechanism in central nervous system cell-cell network
2005 - 2009 Imaging Study of Dynamic Cellular Signaling
2000 - 2004 細胞内シグナルフローの可視化解析
1996 - 2001 カルシウムシグナル研究の先端的手法による展開
1999 - 1999 リバース薬理学の展開
1999 - 1999 Biological Functions and Designed Probe Compounds
1998 - 1999 Analysis of point mutations in the ryanodine receptor gene from malignant hyperthermia patients who showed highly accelerated CICR
1997 - 1998 細胞内情報伝達の生理機能解析と情報分子の可視化
1996 - 1996 機能探索設計分子の開発とその評価
1996 - 1996 興奮収縮連関機構の構造機能協関
1995 - 1996 Analysis of calcium oscillations in vascular smooth muscle cells
1995 - 1996 Molecular mechanism of force generation in muscle fibers
1994 - 1995 Molecular mechanism of excitation-contraction coupling in sketeltal muscle : The signal transduction from DHP receptor to ryanodine receptor
1994 - 1994 中枢シナプスの逆行性情報伝達物質の探索
1993 - 1994 Responses of individual smooth muscle cells to sympathetic stimulation visualized within the arterial wall using confocal microscopy
1991 - 1992 Pharmacological study of intracellular Ca^<2+> mobilizing mechanism
1991 - 1992 Molecular mechanism of skeletal muscle excitation-contraction coupling
1989 - 1990 骨格筋小胞体のCaチャンネルとその抑制薬
1989 - 1990 捕捉化合物を用いた平滑筋細胞内カルシウム動員機構の薬理学的研究
1988 - 1990 System for the simultaneous analysis of the electrical activities and morphophysiological function in a single cell.
1985 - 1986 A physiological and pharmacological study of excitation-contraction coupling by using single skeletal muscle fibres whose intracellular medium can be exchanged.
1985 - 1985 急速溶液交換法による筋小胞体からの Ca 遊離機構の研究とそれに対する薬物の影響
1984 - 1984 細胞内Ca2+濃度を固定した時の骨格筋興奮収縮連関とそれに対する薬物の影響
1983 - 1983 細胞内灌流した単一骨格筋線維標本による興奮収縮連関の薬理学的研究
Kinetics of Ca2+ release from inositol 1,4,5-trisphosphate seusitive Ca2+ stores
Regulation of central nervous system functions by Ca2+ signaling mechanism.
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Papers (173)：
Mai Takenaka, Masami Kodama, Takashi Murayama, Mari Ishigami-Yuasa, Shuichi Mori, Ryosuke Ishida, Junji Suzuki, Kazunori Kanemaru, Masami Sugihara, Masamitsu Iino, et al. Screening for Novel Type 2 Ryanodine Receptor Inhibitors by Endoplasmic Reticulum Ca2+Monitoring. Molecular Pharmacology. 2023. 104. 6. 275-286
Enrico Zampese, David L Wokosin, Patricia Gonzalez-Rodriguez, Jaime N Guzman, Tatiana Tkatch, Jyothisri Kondapalli, William C Surmeier, Karis B D'Alessandro, Diego De Stefani, Rosario Rizzuto, et al. Ca2+ channels couple spiking to mitochondrial metabolism in substantia nigra dopaminergic neurons. Science advances. 2022. 8. 39. eabp8701
Nagomi Kurebayashi, Takashi Murayama, Ryosaku Ota, Junji Suzuki, Kazunori Kanemaru, Takuya Kobayashi, Seiko Ohno, Minoru Horie, Masamitsu Iino, Fumiyoshi Yamashita, et al. Cytosolic Ca2+-dependent Ca2+ release activity primarily determines the ER Ca2+ level in cells expressing the CPVT-linked mutant RYR2. The Journal of general physiology. 2022. 154. 9
Nami Kitajima, Kenji Takikawa, Hiroshi Sekiya, Daisuke Asanuma, Hirokazu Sakamoto, Shigeyuki Namiki, Masamitsu Iino, Kenzo Hirose. In vivo Fluorescence Imaging of Extracellular ATP in the Mouse Cerebral Cortex with a Hybrid-type Optical Sensor. Bio-protocol. 2021. 11. 11. e4046
Carole Escartin, Elena Galea, András Lakatos, James P O'Callaghan, Gabor C Petzold, Alberto Serrano-Pozo, Christian Steinhäuser, Andrea Volterra, Giorgio Carmignoto, Amit Agarwal, et al. Reactive astrocyte nomenclature, definitions, and future directions. Nature neuroscience. 2021. 24. 3. 312-325
Functional properties of inositol 1,4,5-trisphosphate receptor and Ca<sup>2+</sup> signaling.
In Organellar Ion Channels and Transporters. Clapham, D. E. & Ehrlich, B. E. editors. Rockefeller University Press : New York. 1996
Ca<sup>2+</sup> release mechanisms in smooth muscle.
In Smooth Muscle Excitation. Bolton, T. B. & Tomita, T. editors. Academic Press : London. 1996
Ca<sup>2+</sup> release mechanisms in single smooth muscle cells.
Japan Sci. Soc. Press : Tokyo/S. Karger : Basel. 1995
1976 - 1980 Tohoku University Graduate School of Medicine
1970 - 1976 Tohoku University School of Medicine
Professional career (1)：
MD, PhD (Tohoku University)
Work history (5)：
2023/10 - 現在 Teikyo University Advanced Comprehensive Research Organization
2021/04 - 現在 The University of Tokyo
2021/04 - 現在 日本大学医学部 生理学分野 上席研究員
2016/04 - 2021/03 Nihon University School of Medicine Project Professor
1995/04 - 2016/03 The University of Tokyo Graduate School of Medicine Professor
Committee career (5)：
2017/06 - 2023/06 日本医学会/日本医学会連合 副会長
2006/03 - 2020/09 日本学術会議 連携会員
2014/03 - 2016/03 (公社)日本薬理学会 理事長
2010/04 - 2011/03 日本薬理学会 年会長
2006/04 - 2010/03 日本薬理学会 理事
Awards (6)：
2024/04 - The Order of the Rising Sun, Gold Rays with Neck Ribbon
2020/03 - Toray Science Foundation Toray Science and Technology Prize Studies on regulatory mechanisms of cell functions by calcium
2017/04 - Medal with Purple Ribbon
2013/03 - Japanese Pharmacological Society Setsuro Ebashi Award
2009/03 - The Uehara Memorial Foundation Uehara Prize
1990/03 - 日本薬理学会学術奨励賞
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Association Membership(s) (6)：
THE JAPAN NEUROSCIENCE SOCIETY
, Society for neuroscience
, The Physiological Society
, THE BIOPHYSICAL SOCIETY OF JAPAN
, THE PHYSIOLOGICAL SOCIETY OF JAPAN
, THE JAPANESE PHARMACOLOGICAL SOCIETY
