Nakaya Michio

ナカヤミチオ | Nakaya Michio

Affiliation and department：
Homepage URL (1)： http://210.233.60.66/~chudoku/

Research field (3)： Pharmacology , Pharmaceuticals - health and biochemistry , Molecular biology

Research keywords (4)： myofibroblast , fibrosis , 心臓 , G蛋白質

Research theme for competitive and other funds (18)：

2020 - 2023 筋線維芽細胞に特異的に発現する線維化促進分子の機能解析とその創薬応用への基盤構築
2017 - 2021 Analysis of the roles and interaction of various cells including myofibroblasts involved in fibrosis after myocardial infarction
2017 - 2021 機械的刺激を感知し、組織の線維化を促進する転写共役因子の機能解析とそれを基盤とした新規線維化治療法の開発
2018 - 2020 Search for cell membrane marker protein specifically expressed in cancer-associated fibroblasts and its therapeutic application
2017 - 2020 Development of innovative fibrosis therapy targeting a receptor specifically expressed in myofibroblasts

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Papers (57)：

Yuma Horii, Shoichi Matsuda, Chikashi Toyota, Takumi Morinaga, Takeo Nakaya, Soken Tsuchiya, Masaki Ohmuraya, Takanori Hironaka, Ryo Yoshiki, Kotaro Kasai, et al. VGLL3 is a mechanosensitive protein that promotes cardiac fibrosis through liquid-liquid phase separation. Nature Communications. 2023. 14. 1
Akiomi Nagasaka, Tsuyoshi Terawaki, Makoto Noda, Miyuki Takashima, Mika Fujino, Yuto Yamauchi, Shigeki Arawaka, Takeo Kato, Michio Nakaya. GRK5 -mediated inflammation and fibrosis exert cardioprotective effects during the acute phase of myocardial infarction. FEBS Open Bio. 2023. 13. 2. 380-391
Yuya Yoshida, Naoya Matsunaga, Takaharu Nakao, Kengo Hamamura, Hideaki Kondo, Tomomi Ide, Hiroyuki Tsutsui, Akito Tsuruta, Masayuki Kurogi, Michio Nakaya, et al. Alteration of circadian machinery in monocytes underlies chronic kidney disease-associated cardiac inflammation and fibrosis. Nature Communications. 2021. 12. 1
Noburo Takizawa, Takanori Hironaka, Kyosuke Mae, Tomoyuki Ueno, Yuma Horii, Akiomi Nagasaka, Michio Nakaya. GPRC5B promotes collagen production in myofibroblasts. Biochemical and Biophysical Research Communications. 2021. 561. 180-186
Kotaro Kasai, Yuma Horii, Takanori Hironaka, Kyosuke Mae, Tomoyuki Ueno, Akiomi Nagasaka, Michio Nakaya. Increased Expression of Heparan Sulfate 6-O-Sulfotransferase-2 Promotes Collagen Production in Cardiac Myofibroblasts. BPB Reports. 2021. 4. 3. 85-91

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MISC (26)：

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Books (1)：

Lectures and oral presentations (11)：

心筋梗塞時における死細胞の貪食
(日本薬学会, 第138年会 2018)
BLT1は心筋梗塞時における炎症を悪化させる
(酸素生物学・ダイイングコード合同若手会議 2018)
基礎研究から創薬へ
(創薬等ライフサイエンス研究支援基盤事業(BINDS事業)2017年度九大拠点アカデミア創薬シンポジウム 2018)
心筋梗塞時におけるプロトン感知性受容体(GPR4)の役割解析
(第34回日本薬学会九州支部大会 2017)
BLT1は心筋梗塞時における炎症を悪化させる
(第70回日本薬理学会西南部会 2017)

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Work history (1)：

Awards (1)：

Association Membership(s) (5)：

THE JAPANESE BIOCHEMICAL SOCIETY , THE JAPANESE PHARMACOLOGICAL SOCIETY , THE PHARMACEUTICAL SOCIETY OF JAPAN , 日本結合組織学会 , 日本Cell Death学会

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