Rchr
J-GLOBAL ID：200901038760262353   Update date: Oct. 24, 2024

Sano Makoto

サノ マコト | Sano Makoto
Affiliation and department：
Japan Organization of Occupational Health and Safety

About Japan Organization of Occupational Health and Safety


Research field  (6)： Environmental effects of chemicals ,  Hygiene and public health (laboratory) ,  Experimental pathology ,  Cell biology ,  Tumor biology ,  Tumor diagnostics and therapeutics
Research keywords  (4)： オルガノイド・臓器チップ ,  Pancreatic cancer mouse model ,  有害性試験 ,  Translational research
Research theme for competitive and other funds  (11)：
  • 2024 - 2027 担がんマウスモデルを用いた麻酔薬、鎮痛薬の腫瘍ならびに免疫機構への作用機序の解明
  • 2022 - 2026 腹腔内移行経路による腫瘍微小環境編集と難治性腹膜播種治療への展開
  • 2021 - 2024 Inhibition of sleep disorder and pancreatic tumor by improvement of circadian rhythm in a mouse model with pancreatic ductal adenocarcinoma
  • 2021 - 2024 Establishment of new cancer-supportive care in tumor-bearing mouse models
  • 2019 - 2022 Novel hyperthermia immunotherapy for pancreatic cancer by pancreas-specific nano DDS
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Papers (40)：
  • Kato H, Sato M, Ito-Naiki A, Inaguma S, Sano M, Komura M, Nagayasu Y, Xiaochen K, Kato A, Matsuo Y, et al. The role of DPYD and the effects of DPYD suppressor Luteolin combined with 5-FU in pancreatic cancer. Cancer Medicine. 2024. 13. 16. e70124
  • Kuramochi T, Sano M, Kajiwara I, Oshima Y, Itaya T, Kim J, Ichimaru Y, Kitajima O, Masamune A, Ijichi H, et al. The effects of tramadol via a μ-opioid receptor on pancreatic ductal adenocarcinoma in vitro and in vivo. Regional Anesthesia & Pain Medicine. 2024. 49. 3. 200-208
  • Itaya T, Sano M, Kajiwara I, Oshima Y, Kuramochi T, Kim J, Ichimaru Y, Kitajima O, Masamune A, Ijichi H, et al. Mirogabalin improves cancer-associated pain but increases the risk of malignancy in mice with pancreatic cancer. PAIN. 2023. 164. 7. 1545-1554
  • Tomoharu Yamada, Ryosuke Tateishi, Miwako Iwai, Minoru Tanaka, Hideaki Ijichi, Makoto Sano, Kazuhiko Koike, Tomoki Todo. Overcoming resistance of stroma-rich pancreatic cancer with focal adhesion kinase inhibitor combined with G47∆ and immune checkpoint inhibitors. Molecular Therapy Oncolytics. 2022. 28. 31-43
  • Yamamoto M, Kurino T, Matsuda R, Jones HS, Nakamura Y, Kanamori T, Tsuji AB, Sugyo A, Tsuda R, Matsumoto Y, et al. Delivery of aPD-L1 antibody to i.p. tumors via direct penetration by i.p. route: beyond EPR effect. J Control Release. 2022. 352. 328-337
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MISC (6)：
  • Makoto Sano, Ryota Takahashi, Hideaki Ijichi, Kazunaga Ishigaki, Tomoharu Yamada, Koji Miyabayashi, Suguru Mizuno, Takuma Nakatsuka, Yasuo Tanaka, Yohei Masugi, et al. Blocking VCAM-1 inhibits pancreatic tumor progression and cancer-associated thrombosis/thromboembolism. CANCER SCIENCE. 2021. 112. 490-490
  • 大島雪乃, 佐野誠, 市丸嘉, 梶原一絵, 板谷朋亮, 蔵持智也, 金眞淑, 伊地知秀明, 伊地知秀明, 石井敬基, et al. 膵癌モデルに対するミダゾラムの疼痛緩和・抗腫瘍・抗炎症効果. 日本癌学会学術総会抄録集(Web). 2021. 80th
  • Makoto Sano, David R. Driscoll, Wilfredo E. DeJesus-Monge, David S. Klimstra, Brian C. Lewis. Activation of Wnt/beta-catenin in acinar cells accelerates Kras-induced PDAC, while activation of Wnt signaling pathways in stroma induces mucinous cystic neoplasm. CANCER RESEARCH. 2015. 75
  • Makoto Sano, David Driscoll, David S. Klimstra, Wilfredo DeJesus-Monge, Brian C. Lewis. Involvement of canonical Wnt/beta-catenin signaling pathway in pancreatic ductal adenocarcinoma. CANCER RESEARCH. 2012. 72
  • Makoto Sano, Emiko Hayashi, Taku Homma, Yukari Obana, Julie Plaisancie, Tsutomu Yamada, Masahiko Sugitani, Norimichi Nemoto. Expression of the glycoprotein 2G12 is associated with a poor prognosis in pancreatic ductal carcinoma patients. CANCER RESEARCH. 2009. 69
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Books (2)：
  • Testicular Cancer Research Trends: Chapter II- Expression of Bcl-2 family members in testicular germ cell tumors.
    Nova Science Publishers, Inc.; New Yolk 2007
  • Research Advances in Biological Chemistry: The role of Mcl-1, an anti-apoptotic Bcl-2 family member, in the mammalian embryogenesis and fetal development
    Global Research Network 2004
Education (1)：
  • 1997 - 2001 Keio University Graduate School, Division of Medicine Pathology
Professional career (1)：
  • PhD (Medical Science) (Keio University)
Work history (9)：
  • 2024/07 - 現在 National Institute of Occupational Safety and Health, Japan Toxicological Test Methodology Development Group Director
  • 2023/03 - 2024/06 Nihon University School of Medicine Department of Anesthesiology Research Manager
  • 2020/03 - 2023/02 Nihon University School of Medicine Division of Medical Research Planning and Development Associate Professor
  • 2016/10 - 2020/02 Nihon University School of Medicine Division of Human Pathology, Department of Pathology, Part-time Instructor
  • 2016/10 - 2020/02 The University of Tokyo Department of Gastroenterology, Graduate School of Medicine Project Researcher
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Committee career (1)：
  • 2012/04 - 現在 Japanese Society of Pathology Councilor
Awards (2)：
  • 2021/01 - Pancreatic Cancer Action Network PanCan Award (Best Basic Research Award)
  • 2015/12 - Pancreas Research Foundation of Japan 23th Research Award in Pancreas Research Foundation of Japan
Association Membership(s) (7)：
International Association of Pancreatology ,  JAPAN PANCREAS SOCIETY ,  Japanese Society of Pathology ,  Japanese Cancer Association ,  American Association for Cancer Research ,  The Japanese Society of Toxicology ,  Japan Society for Occupational Health (JSOH)
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