LEE Jong-Kook

リショウコク | LEE Jong-Kook

Affiliation and department：
Job title： Professor (Specially-appointed, full-time)

Research field (5)： Clinical pharmacy , Physiology , Cardiology , Biomaterials , Biomedical engineering

Research keywords (6)：イオンチャネル , 不整脈 , バイオペースメーカ , ion channel , cardiac arrhythmia , biological pacemaker

Research theme for competitive and other funds (8)：

2004 - 2005 再生心筋を用いた不整脈治療への新しいアプローチ:「バイオペースメーカー」の開発
2004 - 2005 Generataion of biological pacemaker using stem cell derived cardiac cells.
内向き整流Kチャネルの構造と機能
心臓突然死のメカニズムに関する研究
遺伝子工学的手法を用いた心筋細胞興奮性の調節

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Papers (64)：

Satoshi Kameda, Shuichiro Higo, Mikio Shiba, Takumi Kondo, Junjun Li, Li Liu, Tomoka Tabata, Hiroyuki Inoue, Shota Okuno, Shou Ogawa, et al. Modeling Reduced Contractility and Stiffness Using iPSC-Derived Cardiomyocytes Generated From Female Becker Muscular Dystrophy Carrier. JACC: Basic to Translational Science. 2023
Takumi Kondo, Shuichiro Higo, Mikio Shiba, Yasuaki Kohama, Satoshi Kameda, Tomoka Tabata, Hiroyuki Inoue, Shota Okuno, Shou Ogawa, Satoki Nakamura, et al. Human-Induced Pluripotent Stem Cell-Derived Cardiomyocyte Model for TNNT2 Δ160E-Induced Cardiomyopathy. Circulation. Genomic and precision medicine. 2022. 101161CIRCGEN121003522
Kiyoshi Masuyama, Tomoaki Higo, Jong-Kook Lee, Ryohei Matsuura, Ian Jones, Chris Bakal, Shuichiro Higo, Sachio Morimoto, Shigeru Miyagawa, Yoshiki Sawa, et al. Homogeneous 2D and 3D alignment of cardiomyocyte in dilated cardiomyopathy revealed by intravital heart imaging. Scientific Reports. 2021. 11. 1
Haruki Shinomiya, Hisakazu Kato, Yuki Kuramoto, Nozomi Watanabe, Toshihiro Tsuruda, Tadaaki Arimura, Yohei Miyashita, Yoshiki Miyasaka, Tomoji Mashimo, Ayako Takuwa, et al. Aberrant accumulation of TMEM43 accompanied by perturbed transmural gene expression in arrhythmogenic cardiomyopathy. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2021. 35. 11. e21994
Yayoi Honda, Jun Li, Aya Hino, Shinji Tsujimoto, Jong-Kook Lee. High-Throughput Drug Screening System Based on Human Induced Pluripotent Stem Cell-Derived Atrial Myocytes ∼ A Novel Platform to Detect Cardiac Toxicity for Atrial Arrhythmias. Frontiers in Pharmacology. 2021. 12

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MISC (134)：

Jong-Kook Lee. Protocol for Morphological and Functional Phenotype Analysis of hiPS-Derived Cardiomyocytes. Methods Mol Biol/ Pluripotent Stem-Cell Derived Cardiomyocytes. 2021. 91-100
Masato Shibamoto, Tomoaki Higo, Atsuhiko T. Naito, Akito Nakagawa, Tomokazu Sumida, Katsuki Okada, Taku Sakai, Yuki Kuramoto, Toshihiro Yamaguchi, Masamichi Ito, et al. Activation of DNA Damage Response and Cellular Senescence in Cardiac Fibroblasts Limit Cardiac Fibrosis After Myocardial Infarction (vol 60, pg 944, 2019). INTERNATIONAL HEART JOURNAL. 2021. 62. 1. 220-220
Akira Yoshida, Jong-Kook Lee, Shigeru Miyagawa, Yoshiki Sawa, Yasushi Sakata, Issei Komuro. In Vitro Model of Allogenic Cell Transplantation for Conduction Defects - Electrical Coupling Between Rat iPS Cell-Derived Cardiac Cells and Rat Native Cardiac Cells. CIRCULATION. 2016. 134
三輪佳子, 横山光樹, 宮川繁, 田畑泰彦, 澤芳樹, 李鍾國. LIF徐放性ハイドロゲルを用いた心筋・神経共培養系における神経伸長効果の検討. 日本バイオマテリアル学会大会予稿集. 2015. 37回. 334-334
H. Iseoka, S. Miyagawa, S. Fukushima, S. Masuda, A. Saito, S. Yajima, E. Ito, J. Lee, Y. Sawa. Development of Functional Tissue-engineered Artificial Cardiac Construct generated by Human Induced Pluripotent Stem Cells. TISSUE ENGINEERING PART A. 2015. 21. S212-S213

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Books (7)：

再生医療と不整脈治療
CATHLAB JIN Heart Rhythm(メディカルアイ) 2021
スマートウォッチと不整脈
心電図(日本不整脈心電学会誌) 2021
再生医療と不整脈
BIO Clinica(北隆館) 2020
たこつぼ症候群における分子メカニズム(明石嘉浩編:「たこつぼ症候群のすべて」)
医学のあゆみ2020 (医歯薬出版) 2020
不整脈の考えかた,治しかた
中外医学社 2019 ISBN:9784498136564

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Lectures and oral presentations (24)：

Transitional sympathetic dysinnervation underlie pathophysiological process of Takotsubo syndrome
(CVMW 2020 37th ISHR 2021)
Sympathetic Innervation Promotes Self-Organization and Maturation of iPS cell-derived Cardiomyocytes: Implication for Organoids and Three-dimensional Bioartificial Hearts
(2021)
バイオペースメーカ研究の最近の動向と展望
(第13回植込みデバイス関連冬季大会 2021)
Homogeneous Array of Cardiomyocytes in Dilated Cardiomyopathy Revealed by Intravital Heart Imaging
(AHA Scientific Sessions 2020 2020)
Sympathetic Innervation Facilitated the Self-organization of iPS Cell-derived Cardiac Tissues
(2020)

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Works (5)：

自律神経支配を有する「バイオペースメーカ」構築の試み
2008 -
軸索誘導による神経・心筋細胞間ネットワーク形成~再生心筋における神経支配の構築
2007 -
心筋細胞間ネットワーク解析~興奮伝播のメカニズムを探る
2006 -
洞結節の再生~生体ナノ工学を駆使した「バイオペースメーカ」の機能的構築
2006 -
再生心筋を用いた不整脈治療への新しいアプローチ:「バイオペースメーカ」の開発
2004 -

Education (2)：

1993 - 1998 Nagoya University Graduate School of Medicine Circulation
1981 - 1987 Nagoya University School of Medicine

Work history (10)：

2023/10 - 現在 Osaka University Graduate School of Medicine Department of Cardiovascular Regenerative Medicine and Drug Discovery Professor (Specially-appointed, full-time)
2023/04 - 2023/09 Osaka University Graduate School of Medicine Department of Cardiovascular Medicine Visiting Professor
2022/11 - 2023/03 Osaka University Graduate School of Medicine Department of Medical Therapeutics for Advanced Heart Failure Professor (Speciall-appointed, full-time)
2019/09 - 2022/10 Osaka University Graduate School of Medicine Department of Cardiovascular Regenerative Medicine Professor (Specially-appointed, Full-time)
2016/09 - 2019/08 Osaka University Graduate School of Medicine Department of Advanced Cardiovascular Regenerative Medicine Associate Professor (Specially-appointed, Full-time)

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Association Membership(s) (9)：

日本心血管インターベンション学会 , 日本臨床薬理学会 , 日本薬理学会 , 日本内科学会 , 日本心電学会 , 日本循環器学会 , Japanese Society of Interventional Cardiology , The Japanese Society of Clinical Pharmacology and Therapeutics , The Japanese Pharmacological Society

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