Rchr
J-GLOBAL ID：200901039649555739   Update date: Sep. 13, 2024

Imamura Ryu

イマムラ リユウ | Imamura Ryu
Affiliation and department：
Osaka University Premium Research Institute for Human Metaverse Medicine (PRIMe)

About Osaka University Premium Research Institute for Human Metaverse Medicine (PRIMe)


Job title： Specially Appointed Associate Professor
Homepage URL  (1)： https://prime.osaka-u.ac.jp
Research field  (3)： Immunology ,  Pathobiochemistry ,  Molecular biology
Research keywords  (7)： cell detah ,  innate immune response ,  Met ,  Hepatocyte growth factor ,  転写因子 ,  炎症 ,  Fasリガンド
Research theme for competitive and other funds  (13)：
  • 2012 - 2015 抗炎症NLRファミリー分子PYNODの発現制御機構の解析
  • 2011 - 2014 炎症抑制型NLR蛋白PYNODの生理的・病理的役割の解明
  • 2011 - 2013 胃がんおよび大腸がんの発症における細胞質病原体センサー蛋白の役割の解明
  • 2009 - 2011 皮膚におけるASCおよびPYNODの機能の解明
  • 2008 - 2009 ASCを標的とした癌治療法の開発
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Papers (57)：
  • Nichole Marcela Rojas-Chaverra, Ryu Imamura, Hiroki Sato, Toby Passioura, Emiko Mihara, Tatsunori Nishimura, Junichi Takagi, Hiroaki Suga, Kunio Matsumoto, Katsuya Sakai. A cyclic peptide-grafted Fc with hepatocyte growth factor functionality ameliorates hepatic fibrosis in a non-alcoholic steatohepatitis mouse model. iScience. 2024. 27. 8. 110426-110426
  • Ryu Imamura, Hiroki Sato, Dominic Chih-Cheng Voon, Takayoshi Shirasaki, Masao Honda, Makoto Kurachi, Katsuya Sakai, Kunio Matsumoto. Met receptor is essential for MAVS-mediated antiviral innate immunity in epithelial cells independent of its kinase activity. Proceedings of the National Academy of Sciences of the United States of America. 2023. 120. 40. e2307318120
  • Katsuya Sakai, Nozomi Sugano-Nakamura, Emiko Mihara, Nichole Marcela Rojas-Chaverra, Sayako Watanabe, Hiroki Sato, Ryu Imamura, Dominic Chih-Cheng Voon, Itsuki Sakai, Chihiro Yamasaki, et al. Designing receptor agonists with enhanced pharmacokinetics by grafting macrocyclic peptides into fragment crystallizable regions. Nature Biomedical Engineering. 2022. 7. 2. 164-176
  • Naoya Hino, Kimiya Matsuda, Yuya Jikko, Gembu Maryu, Katsuya Sakai, Ryu Imamura, Shinya Tsukiji, Kazuhiro Aoki, Kenta Terai, Tsuyoshi Hirashima, et al. A feedback loop between lamellipodial extension and HGF-ERK signaling specifies leader cells during collective cell migration. Developmental cell. 2022. 57. 19. 2290-2304
  • Takayoshi Shirasaki, Satoshi Yamagoe, Tetsuro Shimakami, Kazuhisa Murai, Ryu Imamura, Kiyo-Aki Ishii, Hiroaki Takayama, Yukako Matsumoto, Natsumi Tajima-Shirasaki, Naoto Nagata, et al. Leukocyte cell-derived chemotaxin 2 is an antiviral regulator acting through the proto-oncogene MET. Nature communications. 2022. 13. 1. 3176-3176
ｍore...
MISC (10)：
  • Hiroki Sato, Katsuya Sakai, Ryu Imamura, Kunio Matsumoto. HGF conversion in bronchial epithelial cells triggers pre-metastatic niche formation in the lung. CANCER SCIENCE. 2022. 113. 1142-1142
  • Hiroki Sato, Ryu Imamura, Katsuya Sakai, Hiroko Oshima, Masanobu Oshima, Kazuhiro Murakami, Yumi Terakado, Yukinari Kato, Seiji Yano, Kunio Matsumoto. Roles of Mature HGF in Gastric Tissue Regeneration and Tumorigenesis. CANCER SCIENCE. 2021. 112. 422-422
  • Takeshi Kinoshita, Ryu Imamura, Takashi Suda. NLRP3 mediates NF-kappa B activation and cytokine gene induction under various cellular stress conditions. CYTOKINE. 2017. 100. 85-85
  • Umemura M., Kawabe T., Kidoya H., Shudo Koyo, Fukui Masayuki, Asano M., Iwakura Y., Matsuzaki G., Yahagi A., Imamura Ryu, et al. Molecular mechanisms of Fas ligand-induced inflammation. Cancer Research Institute report. 2006. 2003. 113-113
  • Wang Y., Hasegawa M., Imamura Ryu, Kinoshita Takeshi, Kondo C., Konaka K., Suda Takashi. PYNOD, a Novel Apaf-1/CED4-like Protein is an Inhibitor of ASC and Caspase-1. Cancer Research Institute report. 2006. 2003. 115-115
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Lectures and oral presentations  (13)：
  • Metastatic platform formation triggered by distal HGF conversion
    (2022)
  • Novel (Non-canonical) function of HGF receptor Met in immune responses against RNA virus infection
    (2022)
  • HGFの活性化に依存した前転移ニッチの形成
    (第80回日本癌学会学術総会 2021)
  • 胃組織修復および発がん機構における活性型HGFの役割
    (第79回日本癌学会学術総会 2020)
  • Impaired ligand-dependent MET activation caused by an extracellular SEMA domain missense mutation in lung cancer
    (2020)
ｍore...
Education (4)：
  • - 1993 Kumamoto University
  • - 1993 Kumamoto University Graduate School, Division of Medicine
  • - 1989 Kumamoto University School of Medicine
  • - 1989 Kumamoto University Faculty of Medicine
Professional career (1)：
  • 医学博士 (熊本大学)
Work history (8)：
  • 2023/04 - 現在 Osaka University Premium Research Institute for Human Metaverse Medicine (PRIMe) Specially Appointed Associate Professor
  • 2020/04 - 2023/03 金沢大学ナノ生命科学研究所 助教(併任)
  • 2011/04 - 2023/03 Kanazawa University Cancer Research Institute
  • 2017/10 - 2020/03 Kanazawa University Institute for Frontier Science Initiative
  • 2007/04 - 2011/04 Kanazawa University
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Association Membership(s) (3)：
THE JAPANESE CANCER ASSOCIATION ,  日本免疫学会 ,  日本分子生物学会
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