Ohnishi Kazunori

オオニシカズノリ | Ohnishi Kazunori

Affiliation and department：
Job title：教授

Research field (1)： Hematology and oncology

Research keywords (2)：血液学 , Hematology

Research theme for competitive and other funds (25)：

2012 - 2015 Isolation of cancer stem cells by the staining nucleic acid and analyses of their molecular specificities
2012 - 2015 BCR-ABL1 mutations in patients with imatinib-resistant chronic myelogenous leukemia
2011 - 2015 白血病に対する標準的治療法の確立に関する研究
2011 - 2014 成人難治性白血病におけるバイオマーカーに基づく層別化治療法の確立に関する研究
2011 - 2013 創薬コンセプトに基づく戦略的治療デザインの確立

2011 - 2013 The metabolome analysis of leukemic stem cell

2009 - 2011 Utility of separation technique of live cancer stem cells with using an energy transfer fluorescence probes

2009 - 2011 A functional quantitative receptor assay using flluoscein labeled hormones with a carbohydrate chain for the evaluation of the hormonal replacement therapy

2008 - 2011 難治性白血病に対する標準的治療法の確立に関する研究

2008 - 2010 Development of phosphor sugar derivatives for hematological malignancy therapy

2006 - 2008 Use of mesenchymal stem cells as a vector for glioma gene therapy

2005 - 2008 臨床研究チームの整備

2005 - 2008 難治性白血病に対する標準的治療法の確立に関する研究

2005 - 2007 Anon-isotopic quantitative receptor assay using biotinylation of ligands and hormones with a carbohydrate chain

2005 - 2006 Research for eradication of CML stem/progenitor cells which resisted Abl kinase inhibitors

2003 - 2006 成人難治性白血病の分子生物学的特徴に基づく治療法に関する研究

2002 - 2004 Enhancement of purging for minimal residual disease by anti-CD33 monoclonal antibody and multidrug resistant modifiers

2001 - 2001 急性前骨髄球性白血病の薬剤耐性例に対する砒素標識ヒト化抗体の有効性と砒素毒性の軽減

2000 - 2001 Retrovirus-mediated gene transfer of hematopoietic stimulating factor receptor cDNA into MDS cells and gene therapy

1999 - 2001 がん細胞の分化誘導機序を基盤とする新しい癌治療法の開発

2000 - 2000 白血病における分子標的療法の至適臨床応用と併用による効果増強に関する研究

1998 - 1999 Study of Resistance Mechanisms of All-trans Retinoic Acid in Acute Promyelocytic Leukemia

1995 - 1996 Cytokine receptor expression and gene in myelodysplastic syndromes.

1995 - 1996 Homeobox B genes expression in human leukemia cell lines during myelomonocytic differentiation

1993 - 1995 Differentiation therapy of acute promylocytic leukemia.

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Papers (180)：

Michinori Ogura, Kazuhito Yamamoto, Yasuo Morishima, Masashi Wakabayashi, Kensei Tobinai, Kiyoshi Ando, Naokuni Uike, Mitsutoshi Kurosawa, Hiroshi Gomyo, Masafumi Taniwaki, et al. Long-term follow-up after R-High CHOP/CHASER/LEED with Auto-PBSCT in untreated mantle cell lymphoma-Final analysis of JCOG0406. Cancer science. 2023. 114. 8. 3461-3465
Takaaki Ono, Naoto Takahashi, Masahiro Kizaki, Tatsuya Kawaguchi, Ritsuro Suzuki, Kazuhito Yamamoto, Kazunori Ohnishi, Tomoki Naoe, Itaru Matsumura. Clinical outcomes of second-generation tyrosine kinase inhibitors versus imatinib in older patients with CML. Cancer science. 2023. 114. 3. 995-1006
Ken Ohmachi, Michinori Ogura, Yoshitoyo Kagami, Yosuke Imai, Takayuki Hirose, Tomohiro Kinoshita, Hirokazu Nagai, Kazunori Ohnishi, Tomomitsu Hotta. A multicenter, phase II study of full-dose THP-COP therapy for elderly patients with newly diagnosed, advanced-stage, aggressive non-Hodgkin lymphoma. JOURNAL OF CLINICAL AND EXPERIMENTAL HEMATOPATHOLOGY. 2022. 62. 4. 202-207
Takaaki Ono, Naoto Takahashi, Masahiro Kizaki, Tatsuya Kawaguchi, Ritsuro Suzuki, Kazuhito Yamamoto, Kazunori Ohnishi, Tomoki Naoe, Itaru Matsumura. Prognostic effect of comorbidities in patients with chronic myeloid leukemia treated with a tyrosine kinase inhibitor. Cancer science. 2020. 111. 10. 3714-3725
Masatoshi Sakurai, Shinichiro Okamoto, Itaru Matsumura, Satsuki Murakami, Makiko Takizawa, Masato Waki, Daiki Hirano, Reiko Watanabe-Nakaseko, Naoki Kobayashi, Masaki Iino, et al. Treatment outcomes of chronic-phase chronic myeloid leukemia with resistance and/or intolerance to a 1st-line tyrosine kinase inhibitor in Japan: the results of the New TARGET study 2nd-line. International journal of hematology. 2020. 111. 6. 812-825

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MISC (423)：

大西一功. 【急性骨髄性白血病(AML)-新分類・分子病態・治療-】(序)急性骨髄性白血病におけるprecision medicineはどこまで到達したか. 血液フロンティア. 2017. 27. 4. 495-498
Koichi Miyamura, Shigeki Ohtake, Kazunori Ohnishi, Noriko Usui, Chiaki Nakaseko, Hiroyuki Fujita, Shin Fujisawa, Toru Sakura, Hirokazu Okumura, Yoshihiro Hatta, et al. Phase III Randomized Study of Imatinib Therapy in Chronic Phase Chronic Myeloid Leukemia Comparing Standard Dose-Escalation with Progressive Dose-Escalation (JALSG CML207 study). BLOOD. 2016. 128. 22
花井美惠, 津田待美, 市川幸子, 深澤詩子, 伊藤美香, 内海雪美, 名倉まい, 末永典子, 村瀬沙織, 相澤峰子, et al. 機種別・採血種別におけるクエン酸反応の発生率の違いについて. 血液事業. 2016. 39. 2. 436-436
松田亜沙実, 勝見章, 天野睦紀, 永田泰之, 大西一功, 清井仁, 直江知樹. 血球特異的Rhoファミリー蛋白RhoHはT cell activation GTPase activating protein(TAGAP)を介してRacを不活性化する. 日本癌学会総会記事. 2015. 74回. P-3040
大西一功. G-CSF適正使用ガイドライン一部改訂にかかるコンセンサスミーティング悪性リンパ腫の化学療法におけるG-CSF適性投与. 日本癌治療学会誌. 2015. 50. 3. 1208-1208

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Books (11)：

Chemotherapy for Leukemia-Novel Drugs and Treatment
Springer Nature Singapore 2017
内科診療実践マニュアル改訂第2版
日本医学出版 2016
造血器腫瘍アトラス第5版
日本医事新報社 2016
カラーテキスト血液病学第2版
中外医学社 2013
G-CSF適正使用ガイドライン2013年度版
金原出版 2013

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Lectures and oral presentations (4)：

Current clinical studies of CML treatment in JASG in 2008
(2008)
Lower Dose of Imatinib Provides Outcomes Similar to the Standard Dose Imatinib in Japanese Patients with Early Chronic-Phase CML: The Interim Analyses of JALSG CML202 Study
(49th annual meeting of American Society of Hematology 2007)
Glivec safety evaluation committee interstitial pneumonia during imatinib mesylate therapy
(45th ASH Annual Meeting 2003)
Multicenter prospective study of interferon-alpha versus bone marrow transplantation for newly diagnosed patients with chronic myelogenous leukemia
(43rd ASH Annual Meeting 2001)

Education (1)：

1969 - 1975 Nagoya University School of Medicine

Professional career (1)：

(BLANK)

Work history (10)：

2020/04 - 現在 Shubun University
2018/04 - 2020/03 日本赤十字社東海北陸ブロック血液センター所長
2015/04 - 2018/03 日本赤十字社愛知県赤十字血液センター所長
2015/04 - 国立大学法人浜松医科大学
2012/06 - 2015/03 国立大学法人浜松医科大学医学部臨床腫瘍学講座教授

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Committee career (4)：

2006/04 - 2019/03 特定非営利活動法人成人白血病治療共同研究支援機構理事
2005/04 - 2015/03 Japan Adult Leukemia Study Group(JALSG) 副代表
2008/10 - 2014/10 日本血液学会理事
2014/05 - The 5th JSH International Symposium in Hamamatsu 2014 President

Association Membership(s) (6)：

米国血液学会 , 日本内科学会 , 日本網内系学会 , 日本血液学会 , 日本造血細胞移植学会 , 日本輸血・細胞治療学会

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