Ken Shirabe

2022 - 2025 癌細胞ならびに腫瘍免疫寛容の同時制御を目指した新規治療ツール開発

2021 - 2025 会話分析を用いた協働意思決定過程の解明

2021 - 2024 膵がん治療におけるO-GlcNAc分解酵素OGAの重要性とその分子機構の解明

2021 - 2024 Identification of novel immune check point molecules in exhausted CD8+ T cells

2021 - 2023 IL-17産生γδ型T細胞を制御する新規癌免疫療法の創生を目指した基礎的研究

2019 - 2022 A new liver regeneration molecular mechanism involving hepatic stellate cells, Kupffer cells, and glucose-regulated protein 78 as a new hepatotrophic factor

2019 - 2022 Evaluation of the effect of sarcopenia on liver regeneration from the viewpoint between liver and muscle correlation

2019 - 2022 Development of a new treatment for high-grade neuroendocrine carcinoma of the lung targeting Stathmin1

2018 - 2021 New humoral factor facilitates hepato-biliary and pancreatic cancer progression and development of innovative thrapy

2015 - 2020 Development of Innovative Treatment Targeting the Sphere Formation Mechanism Involving Cancer Stem Cells

2017 - 2019 Development of novel therapeutic agents targeting cancer-associated fibroblasts (CAFs) via suppression of fibrosis in pancreatic cancer.

2016 - 2019 Development of new therapy for enhancing liver regeneration by WFA-M2BP, which is a new biomarker for liver fibrosis.

2016 - 2019 肝細胞の代謝制御におけるオートファジーの意義-KO細胞の網羅的メタボローム解析

2016 - 2019 The roles of Nrf2 on progression in hepatocellular carcinoma

2016 - 2019 Analyses of regulatory B cell functions for tailor-made immunosuppression after liver transplantation

2015 - 2018 Comprehensive epigenome-transcriptome analysis of hepatocellular carcinoma after eradication of hepatitis C

2015 - 2018 The roles of autophagy in liver regenetion in a steatotic liver

2015 - 2018 The biological analysis of sugar chain signal between hepatic stelate cells and macrophages in the progression of liver fibrosis.

2014 - 2017 Mechanism of sarcopnia in outer space

2014 - 2017 Ischemia-Reperfusion Injury in Fatty Liver Is Mediated by Activated NADPH Oxidase 2 in Rats

2014 - 2017 Development of artificial bile duct which has transplantationable strength and biocompatibility by knitting of biocompatible material

2013 - 2016 The role of macrophage of spleen in wound healing and cancer progression

2013 - 2016 Molecular mechanism of autophagy during differentiation and induction of hepatic stem cells in liver injury and regeneration

2013 - 2016 Development of the innovative hybrid artificial liver with establishment of the hepatocyte strain from human iPS cells

2014 - 2015 ヒト癌免疫編成機構の分子機序解明と免疫合成致死を誘導する革新的免疫療法の研究開発

2012 - 2015 Functional and clinical analysis of angiogenic factor apelin in hepatocellular carcinoma

2012 - 2015 The significance of tumor associated macrophage in recurrent hepatocellular carcinoma after liver transplantation

2012 - 2015 Microenvironment in hepatocellular carcinoma

2011 - 2014 Treatment strategies of recurrent hepatitis C after liver transplantation based on IL28B singlencleotide polymorphism.

2011 - 2013 Impact of autophagy in liver regeneration

2010 - 2012 The biological role of autophagy in liver regeneration in pathological condition.

2011 - 2011 レシピエント由来血管内皮幹細胞誘導による生体肝移植後過小グラフト克服

2008 - 2010 Role of Faascin protein in proliferation and invasion of hepatocellular carcinoma.

2004 - 2004 肝細胞癌の脈管浸潤のメカニズム解明と遺伝子治療への応用に関する研究

2002 - 2004 Promotion of liver regeneration and intrahepatic metastasis of hepatocellular carcinoma by Histone acetylation

2002 - 2003 Identification of differentiation regulated gene and application to differentiation inducing gene therapy

2002 - 2003 Development of a Hybrid Artificial Liver for Treatment of Chronic Liver Failure Patients

2000 - 2001 Development of a Hybrid Artificial Liver for Treatment of Acute and Chronic Liver Failure Patients

1999 - 2000 Study of new metastatic mechanism in hepatocellular carcinoma

1998 - 1999 Development of Hybrid Artificial Liver for Clinical Treatment of Fulminant Hepatic Failure Patient

1997 - 1998 肝細胞癌発癌における新しい発癌遺伝子の同定に関する研究

1996 - 1996 肝細胞癌再発における接着因子の意義

1995 - 1995 肝静脈浸潤肝細胞癌の遺伝子解析

1994 - 1995 アポトーシス導入による肝細胞癌の特異的増殖制御