Nishinaka Toru

ニシナカトオル | Nishinaka Toru

Affiliation and department：
Job title： Associate Professor

Research field (4)： Pharmacology , Cell biology , Molecular biology , Functional biochemistry

Research keywords (5)：転写調節 , 生活習慣病 , 発癌 , 酸化的ストレス , カルボニル代謝

Research theme for competitive and other funds (8)：

2006 - 2007 Study on aldo-keto reductases as potential targets of antitumor agents : its involvement in the drug resistance of cancer cells
2002 - 2004 転写因子Nrf2による薬物代謝酵素の発現調節と薬物相互作用に及ぼす効果の解析
1999 - 2000 酸化的ストレスによる糖尿病合併症発症因子の発現誘導と病態モデルでの解析
薬物代謝酵素の発現および活性の調節機構
酸化的ストレス、化学ストレスによって活性化される情報伝達機構に関する研究

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Papers (80)：

Kahori Shimizu, Moe Ono, Takenari Mikamoto, Yuya Urayama, Sena Yoshida, Tomomi Hase, Shotaro Michinaga, Hiroki Nakanishi, Miho Iwasaki, Tomoyuki Terada, et al. Overexpression of lysophospholipid acyltransferase, LPLAT10/LPCAT4/LPEAT2, in the mouse liver increases glucose-stimulated insulin secretion. The FASEB Journal. 2024. 38. 2
Kahori Shimizu, Syogo Nishimuta, Yuri Fukumura, Shotaro Michinaga, Yuka Egusa, Tomomi Hase, Tomoyuki Terada, Fuminori Sakurai, Hiroyuki Mizuguchi, Koji Tomita, et al. Liver-specific overexpression of lipoprotein lipase improves glucose metabolism in high-fat diet-fed mice. PLOS ONE. 2022. 17. 9. e0274297-e0274297
Satoshi Endo, Yoshifumi Morikawa, Toshiyuki Matsunaga, Akira Hara, Toru Nishinaka. Porcine aldo-keto reductase 1C subfamily members AKR1C1 and AKR1C4: Substrate specificity, inhibitor sensitivity and activators. The Journal of steroid biochemistry and molecular biology. 2022. 221. 106113-106113
Satoshi Endo, Tsubasa Nishiyama, Tomoe Matuoka, Takeshi Miura, Toru Nishinaka, Toshiyuki Matsunaga, Akira Ikari. Loxoprofen enhances intestinal barrier function via generation of its active metabolite by carbonyl reductase 1 in differentiated Caco-2 cells. Chemico-biological interactions. 2021. 348. 109634-109634
Satoshi Endo, Toshiyuki Matsunaga, Toru Nishinaka. The Role of AKR1B10 in Physiology and Pathophysiology. Metabolites. 2021. 11. 6

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MISC (10)：

K. Shimizu, Y. Ogiya, T. Nishinaka, F. Sakurai, H. Mizuguchi, K. Tomita, T. Terada. Study of zinc finger AN1-type domain gene transduction by a novel adenovirus vector with lower hepatotoxicity for treatment of diabetes mellitus. HUMAN GENE THERAPY. 2016. 27. 11. A179-A179
Takeshi Miura, Toru Nishinaka, Tomoyuki Terada. Potential Targeting Region for the Specific Inhibition of Human Monomeric Carbonyl Reductases of the Short-Chain Dehydrogenase/Reductase Superfamily. DRUG METABOLISM REVIEWS. 2009. 41. 54-55
Takeshi Miura, Toru Nishinaka, Tomoyuki Terada. COMPARATIVE STUDY OF HUMAN MONOMERIC CARBONYL REDUCTASES IN TISSUE DISTRIBUTION, REDUCTASE ACTIVITY, AND COENZYME SPECIFICITY. DRUG METABOLISM REVIEWS. 2007. 39. 191-192
Takeshi Miura, Toru Nishinaka, Tomoyuki Terada. COMPARATIVE STUDY OF HUMAN MONOMERIC CARBONYL REDUCTASES IN TISSUE DISTRIBUTION, REDUCTASE ACTIVITY, AND COENZYME SPECIFICITY. DRUG METABOLISM REVIEWS. 2007. 39. 263-263
K Iwata, K Matsuno, T Nishinaka, C Yabe-Nishimura. Inhibition of aldose reductase improves myocardial reperfusion injury by a dual mechanism. JOURNAL OF PHARMACOLOGICAL SCIENCES. 2006. 100. 86P-86P

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Education (2)：

Professional career (1)：

Work history (6)：

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Association Membership(s) (3)：

日本薬理学会 , 日本薬学会 , 日本生化学会

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