Takakura Yoshinobu

2014 - 2017 Development of therapeutic systems based on three-dimensional DNA nanostructures

2014 - 2016 Efficient induction of in vivo RNA interference by designing exosome-tropic siRNA derivatives

2014 - 2016 Development of DDS applicable for immune therapy by using self-assembling RNA sponge particle

2013 - 2015 Development of microtissue therapeutic system based on mixed multicellular spheroids

2012 - 2015 Optimization of cytokine gene therapy based on the regulation of transcription/translation, pharmacokinetics, and cellular response.

2012 - 2014 Development of target-specific multifunctional exosomes loaded with RNA drugs

2011 - 2014 Development of nano-sized DDS for nucleic acid drugs based on polypod-like structured nucleic acids

2011 - 2012 Development of targeted cell therapeutic systems based on cell characteristics

2009 - 2011 Design and delivery of plasmid vector for spatiotemporal control of the expression of therapeutic protein and siRNA

2010 - 2010 一回の投与で繰り返しタンパク質を供給可能なオンデマンド型遺伝子治療システムの開発

2009 - 2010 次世代細胞治療に向けた細胞製剤のステルス化・標的指向化

2008 - 2010 DEVELOPMENT OF CANCER CHEMO-IMMUNOTHERAPEUTIC SYSTEM USING REDOX CONTROLLABLE DDS

2009 - 2009 遺伝子発現再活性化現象を利用したリピータブルタンパク質発現システムの開発

2008 - 2009 インターフェロン遺伝子発現の増強・持続化による新規癌治療戦略

2007 - 2008 抗原投与を全く必要としない細胞内抗原トラップ型新規腫瘍ワクチンの開発

2007 - 2008 Development of all inclusive anti tumor immunotherapy based on engineered protein and nucleic acid

2005 - 2006 RNAiによる遺伝子ノックダウンと抗原デリバリーを組み合せた新規免疫療法の確立

2005 - 2006 Design and delivery of nucleic acid drugs for optimization of DNA vaccination

2003 - 2004 In vivo RNAiによる遺伝子ノックダウンマウス作出と薬物動態研究への応用

2003 - 2004 Establishment of novel delivery strategies to dendritic cells and optimization of DNA vaccination

2003 - 2003 プラスミド水溶液投与による高効率遺伝子導入法を利用したがんのサイトカイン療法

2002 - 2002 プラスミド水溶液投与による高効率遺伝子導入法を利用したがんのサイトカイン療法

2001 - 2002 Development of plasmid DNA delivery methods to antigen presenting cells for optimized DNA vaccination

2000 - 2001 Development of local drug disposition analysis and delivery methods in human solid tumors

1999 - 2000 遺伝子医薬品の体内動態および細胞取り込み機構の解明に基づくデリバリー戦略の確立

1998 - 2000 動態-発現相関の解析に基づくin vivo遺伝子導入キャリアーシステムの分子設計

1997 - 1998 Development of Gene Delivery Systems to Intestinal Epithelial Cells as a Target

1996 - 1997 Systematic development of targeting systams for prevention of tissue damages in organ transplantation

1995 - 1996 Development of Delivery Systems for the Control of Pharmacokinetics and Intracellular Trafficking of Antisense Drugs

1995 - 1996 Establishment of the theory based on a skin diffusion model for the optimal design of a new approach to enhanced trandermal drug delivery

1995 - 1995 IFN-γ遺伝子導入による抗腫瘍機構の解析と遺伝子治療へ向けての基礎的研究

1994 - 1994 遺伝子治療を目的とした核酸医薬品のデリバリーシステムの確立

1993 - 1994 Establishment of Evaluation Method for Function of Drug Targeting Systems and Systematization of their Physicochemical Character-Function Relationship

1991 - 1991 タ-ゲティング型製剤の製剤特性ー機能相関の体系化

1990 - 1991 Pharmacokinetic modeling and penetration enhancement of the percutaneous drug absorption based on diffusion theory

1988 - 1989 Establishment of a new theory for assessment of drug disposition

1988 - 1989 Control of biopharmaceutical properties of peptide drugs by chemical modification employing carbohydrates

1986 - 1986 薬物の腫瘍移行性評価システムの開発とそれを利用したターゲティング型抗癌剤設計

遺伝子治療における製剤設計に関する研究

細胞特異的薬物送達に関する研究

Study on Dosage Form Design for Gene Therapy

Study on Cell Specific Drug Delivery