Rchr
J-GLOBAL ID：200901041549747481   Update date: Nov. 05, 2024

Ito Takuhiro

イトウ タクヒロ | Ito Takuhiro
Affiliation and department：
RIKEN Center for Biosystems Dynamics Research

About RIKEN Center for Biosystems Dynamics Research


Job title： Unit Leader
Research field  (1)： Structural biochemistry
Research keywords  (11)： Electron Microscopy ,  X線結晶構造解析 ,  tRNA ,  核酸 ,  修飾塩基 ,  翻訳 ,  翻訳開始因子 ,  リボソーム ,  RNA ,  タンパク質 ,  立体構造
Research theme for competitive and other funds  (12)：
  • 2021 - 2026 Structural Analysis of Non Domain Biopolymer
  • 2021 - 2026 Management of non-domain biopolymer research group
  • 2022 - 2025 Tissue-specific regulation of translation initiation mediated by ribosome heterogeneity
  • 2019 - 2022 Structural basis of traslation regulation by dynamic interactions between the complexes
  • 2017 - 2019 ウイルスが引き起こす非標準的な翻訳機構の構造基盤
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Papers (65)：
  • Hironori Saito, Yuma Handa, Mingming Chen, Tilman Schneider-Poetsch, Yuichi Shichino, Mari Takahashi, Daniel Romo, Minoru Yoshida, Alois Fürstner, Takuhiro Ito, et al. DMDA-PatA mediates RNA sequence-selective translation repression by anchoring eIF4A and DDX3 to GNG motifs. Nature Communications. 2024
  • Peixun Han, Mari Mito, Takuhiro Ito, Shintaro Iwasaki. Sense codon-misassociated eRF1 elicits widespread ribosome stalling and induction of quality control. 2024
  • Yuichi Shichino, Tomokazu Yamaguchi, Kazuhiro Kashiwagi, Mari Mito, Mari Takahashi, Takuhiro Ito, Nicholas T Ingolia, Keiji Kuba, Shintaro Iwasaki. eIF4A1 enhances LARP1-mediated translational repression during mTORC1 inhibition. Nature structural & molecular biology. 2024
  • Mayuki Tanaka, Takeshi Yokoyama, Hironori Saito, Madoka Nishimoto, Kengo Tsuda, Naoyuki Sotta, Hideki Shigematsu, Mikako Shirouzu, Shintaro Iwasaki, Takuhiro Ito, et al. Boric acid intercepts 80S ribosome migration from AUG-stop by stabilizing eRF1. Nature Chemical Biology. 2024
  • Kazuhiro Kashiwagi, Takuhiro Ito. Switching on stress. Nature Chemical Biology. 2023
ｍore...
MISC (11)：
  • 半田佑磨, 半田佑磨, 斉藤大寛, 斉藤大寛, 奥脇弘次, 古石誉之, 米持悦生, 加藤幸一郎, 渡邉千鶴, 本間光貴, et al. Molecular dynamics and quantum chemical calculations for the RNA sequence specificity of eIF4A inhibitors. 日本薬学会年会要旨集(Web). 2024. 144th
  • 藤博貴, 藤田智也, 藤田智也, 横山武司, 横山武司, 田口英樹, 田口英樹, 伊藤拓宏, 岩崎信太郎, 岩崎信太郎. Anatomy of footprint extension in ribosome profiling reveals a conformational landscape of ribosomes in bacteria. 日本生化学会大会(Web). 2023. 96th
  • 柏木 一宏, 伊藤 拓宏. 統合的ストレス応答における翻訳制御の構造生物学-Structural biology of translation regulation in the integrated stress response-特集 翻訳制御の最前線. 細胞. 2022. 54. 12. 688-691
  • HANDA Yuma, KAWASHIMA Yusuke, FURUISHI Takayuki, YONEMOCHI Etsuo, ITO Takuhiro, SAITO Hironori, SAITO Hironori, IWASAKI Shintaro, IWASAKI Shintaro, WATANABE Chiduru, et al. Dynamic FMO analysis for RNA sequence specificity in inhibitor recognition of translation initiation factor complex. CBI学会大会. 2021. 2021 (CD-ROM)
  • 池内与志穂, 岩崎信太郎, 伊藤拓宏. eIF2B結合性ウイルスタンパク質NSsによる統合的ストレス応答抑制. 日本生化学会大会(Web). 2021. 94th
ｍore...
Professional career (1)：
  • Ph.D. (The University of Tokyo)
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