Rchr
J-GLOBAL ID：200901041822341272
Update date: Nov. 26, 2024
Kouguchi Hirokazu
コウグチ ヒロカズ | Kouguchi Hirokazu
Affiliation and department：
Job title：
Researcher/Deputy Director of Division
Homepage URL (1)：
http://www.iph.pref.hokkaido.jp/
Research field (3)：
Parasitology
, Applied biochemistry
, Molecular biology
Research keywords (7)：
人獣共通感染症
, 血清診断抗原
, ワクチン
, Protein
, Vaccine
, Clostridium botulinum
, Echinococcus multilocularis
Research theme for competitive and other funds (16)：
- 2023 - 2026 新規化合物とミトコンドリア標的型ナノカプセルを用いた包虫症の新治療法の基盤的研究
- 2023 - 2026 For coexistence with Echinococcus - Re-evaluation of biological characteristics of Hokkaido-prevalent population based on the new findings
- 2022 - 2025 一次包虫病巣モデルおよび活性化六鉤幼虫を利用したエキノコックス治療法と予防薬開発
- 2020 - 2023 The basic research of unique and effective wild intermediate host animal control methods for alveolar hydatidosis
- 2017 - 2020 Disease control of Echinococcus multilocularis by development of anti-echinococcus drug and vaccine-bait for both definitive and intermediate hosts
- 2015 - 2019 Molecular and functional characterization of glucose transporter genes of the fox tapeworm Echinococcus multilocularis
- 2014 - 2017 An epidemiological study on echinococcosis in Qinghai, China, and development of a chemotherapeutic drug for humans and domestic animals
- 2013 - 2016 Development of practical mucosal vaccine for the final host of Echinococcus multilocularis and characterization of host protective reaction induced by reinfection of the parasite in dogs
- 2013 - 2016 Analysis on gene expression profile in oncosheres and early stage metacestodes from Echinococcus multilocularis
- 2011 - 2013 Development of a vaccine against Echinococcus multilocularis for vectors using pupose-built experimental facilities.
- 2011 - 2012 Development of the oral vaccine for definitive hosts against Echinococcus multilocularis infection based on mucosal immunization
- 2007 - 2008 Studies on development of serodiagnosis system for dog infected in Echinococcus multilocularis by using specific recombinant antigen
- 2006 - 2008 Analysis of cDNA library of Echionococcus multilocularis adult worm for its control measures in dog
- 2005 - 2005 タンパク質抗原を用いる新しいエキノコックス症血清診断法の研究
- 人獣共通感染症に関わる診断・ワクチン開発
- Development of vaccines and diagnosis method for the control of potential zoonotic desease
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Papers (70)：
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Hirokazu Kouguchi, Masahito Hidaka, Hiroyuki Matsuyama, Naoki Hayashi, Tomohito Koyano, Ryo Nakao, Nariaki Nonaka, Kinpei Yagi, Shigehiro Enkai. Synergistic Effects of Anti-echinococcosis Drug Candidates Combined With Atovaquone in Culture Assays and Mice With Primary Infections of Echinococcus multilocularis. Cureus. 2024
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Izumi Kida, Naoki Hayashi, Nozomu Yokoyama, Noriyuki Nagata, Kazuyoshi Sasaoka, Noboru Sasaki, Keitaro Morishita, Kensuke Nakamura, Hirokazu Kouguchi, Kinpei Yagi, et al. Case report: Echinococcus multilocularis infection in a dog showing gastrointestinal signs in Hokkaido, Japan. Frontiers in Veterinary Science. 2024. 11
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Masahito Hidaka, Kohji Uraguchi, Hiroyuki Matsuyama, Hirokazu Kouguchi. The first record of Brachylaima ezohelicis (Trematoda: Brachylaimidae) in the red fox (Vulpes vulpes schrencki). Parasitology International. 2024. 98. 102826-102826
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Naoki Hayashi, Ryo Nakao, Yuma Ohari, Takao Irie, Hirokazu Kouguchi, Elisha Chatanga, Wessam Mohamed Ahmed Mohamed, Mohamed Abdallah Mohamed Moustafa, Gohta Kinoshita, Munehiro Okamoto, et al. Mitogenomic exploration supports the historical hypothesis of anthropogenic diffusion of a zoonotic parasite Echinococcus multilocularis. iScience. 2023. 107741-107741
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Shigehiro Enkai, Hirokazu Kouguchi, Daniel Ken Inaoka, Tomoo Shiba, Masahito Hidaka, Hiroyuki Matsuyama, Takaya Sakura, Kinpei Yagi, Kiyoshi Kita. Killing Two Birds with One Stone: Discovery of Dual Inhibitors of Oxygen and Fumarate Respiration in Zoonotic Parasite, Echinococcus multilocularis. Antimicrobial Agents and Chemotherapy. 2023
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MISC (83)：
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中村鉄平, 市居修, 入江隆夫, 篠原明男, 孝口裕一, 昆泰寛, 森松正美. コットンラットの胸腺にみられる嚢胞の由来と胸腺機能との関連. 日本獣医学会学術集会講演要旨集. 2023. 166th
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林直樹, 入江隆夫, 尾針由真, 孝口裕一, CHATANGA Elisha, 木下豪太, 八木欣平, 中尾亮, 野中成晃. Genetic diversity of Echinococcus multilocularis in Hokkaido and the verification of crossbreeding between populations. 日本寄生虫学会大会プログラム・抄録集. 2022. 91st
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林直樹, 入江隆夫, 尾針由真, 木下豪太, 孝口裕一, 八木欣平, 中尾亮, 野中成晃. 北海道に分布する多包条虫Echinococcus multilocularisのミトゲノムにおける遺伝的多様性. 日本獣医学会学術集会講演要旨集. 2021. 164th (CD-ROM)
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林直樹, 中尾亮, 孝口裕一, 今里裕平, 入江隆夫, 八木欣平, 野中成晃. Comparative analysis on the migration dynamics of Echinococcus multilocularis oncospheres in two mouse strains. 日本寄生虫学会大会プログラム・抄録集. 2020. 89th
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今里裕平, 中尾亮, 孝口裕一, 入江隆夫, 八木欣平, 野中成晃. Considering the assembly methods for the draft genome of Echinococcus multilocularis using the long-read sequencer MinION. 日本寄生虫学会大会プログラム・抄録集. 2020. 89th
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Patents (2)：
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多包条虫由来の新規蛋白質
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モノクローナル抗体、ハイブリドーマ、腸管毒素の検査方法及びその除去方法
Books (1)：
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Current Topics in Food Science and Technology, (Structure and function of the Clostridium botulinum serotypes C and D toxin complex)
Reseach Signpost 2005 ISBN:8130800039
Professional career (1)：
Work history (6)：
Committee career (1)：
- 2020/01 - 現在 北海道エキノコックス症対策協議会 特別委員
Awards (2)：
- 2019/06 - 地方衛生研究所全国協議会 会長奨励賞
- 2009 - 地方衛生研究所設立60周年記念表彰 学術貢献賞 (八木欣平、加藤芳伸、伊藤拓也、孝口裕一)
Association Membership(s) (4)：
日本細菌学会
, 日本生化学会
, 日本衛生動物学会
, 日本寄生虫学会
