Rchr

J-GLOBAL ID：200901041886054250 Update date: Nov. 21, 2024

Yamaguchi Akira

ヤマグチアキラ | Yamaguchi Akira

Affiliation and department：
Job title： Others

Research field (3)： Oral medicine (pathology) , Oral medicine , Experimental pathology

Research keywords (3)： Bone cell biology , Oral Pathology , Pathology

Research theme for competitive and other funds (75)：

2024 - 2027 カエルの骨格から探る脊椎動物の骨強度獲得機構の包括的理解
2022 - 2025 Differentiation mechanism of cell groups appearing in the healing process of pulp revascularization procedure.
2020 - 2023 GABA受容体rho2の破骨細胞分化調節機構の解明とそのアゴニストの臨床応用
2020 - 2023 FGF23産生機序とリン代謝異常を基軸とする顎骨線維性骨異形成症の包括的病態理解
2019 - 2022 Establishment of Platform for Dentin Regeneration Drug Discovery by Targeting Multiple Signals that Regulate Odontoblast Function and Differentiation

2017 - 2020 Establishment and application of disease-specific iPS cells for Apert syndrome

2017 - 2020 Multiscale analysis of peri-implant bone based on mechanobiology

2016 - 2020 Development and application of the trace elements and micro structure analyses of tissue specimens using the quantum beams

2016 - 2018 Establishment of iPS cells from McCune-Albright syndrome and it application

2014 - 2017 The analysis of the role of CCN3 in the formation of vascularization at the tissue regeneration and the constraction of the drug discovery

2014 - 2016 Evolutional investigation of the hematopoietic niches in bone marrow

2013 - 2016 Comprehensive analyses of the mechanism of bone destruction by oral cancer

2011 - 2014 Visualization of oral cancer microenvironment using molecular imaging and its application to radiotherapy

2011 - 2013 Serum calcium upregulates Fgf23 expression by Dickopf-1-mediated inhibition of Wnt/beta-catenin signaling in bone

2011 - 2012 Investigation for the bone clock development by bioluminescence and fluorescence imaging on brain and bone

2011 - 2012 Challenge to clarify the acquirement of osteonetwork

2010 - 2012 Strategic Survey of Trends Toward Oral Pathology Standardization and Oral Pathology Board Certification in Asia for the New Century

2010 - 2012 Maintenance and disturbance of osteonetwork: basic studies on clarification of pathophysiology of craniofacial bone diseases

2009 - 2011 Pathophysiological significance of altered kerakin expression in oral cancer

2009 - 2010 骨再生過程におけるOsteocrine factorの同定

2007 - 2009 Crosstalk among cells and molecules during bone regeneration

2006 - 2007 Analysis of regulation of osteogenesis by Notch signaling andits application to boneregeneration therapy

2006 - 2007 Regeneration of resorbed tooth roots by cementogenesis

2005 - 2006 脊椎動物の進化における骨格形成の変遷を解析するための基盤研究

2002 - 2006 Comprehensive analysis of bone formation and its application

2004 - 2005 二本鎖RNAを導入したC.elegansの渦巻き反射と重力ストレス-痛み受容相関

2003 - 2004 gene therapy for massive bone defects : Development of the delivery system for clinical use

2002 - 2004 Evaluation of 9.4-T MR microimaging in assessing normal and defective fetal bone development : comparison of MR imaging and histological findings

2002 - 2004 Comprehensive approach to identify novel molecules involved in osteogenesis and chondrogenesis during tooth development.

2000 - 2004 骨芽細胞の分化調節機構を基盤として新しい骨再生療法を開発する

2002 - 2003 歯周組織幹細胞(Periodontal Stem Cell)は存在するか?

2002 - 2003 ヒト過誤腫から多分化能を保持した細胞株を樹立し、骨軟骨分化機構解析に利用する試み

2002 - 2003 Functional analysis of TNF signaling in bone metabolism using knocked-out mice of type I and II TNF receptors.

2001 - 2002 Microscopic analysis of three-dimensional trabecular structure using X-ray and syncrotron radiation

2000 - 2002 炎症性サイトカイン関連遺伝子変異マウスを用いて歯周組織破壊と再生の機序を解析する

2000 - 2001 カエルのオタマジャクシと成体の骨格の解析により骨粗鬆症の病態像を再考する試み

2000 - 2001 Exhaustive analysis of gene expression dining bone regeneration

2000 - 2001 DEVELOPMENT OF A NEW THERAPEUTC APPROCH TO BONE REGENERATION FOR GENE THERAPY

1999 - 1999 骨格系の制御プログラムと疾患

1999 - 1999 骨芽細胞の分化調節機構の細胞生物学的・分子生物学的解析

1998 - 1999 cbfa1ヘテロ接合体マウスはヒト鎖骨頭蓋異形成症のモデルとなるか?

1998 - 1999 Recovery of bone forming ability with bone morphogenetic protein from radiation injury

1998 - 1999 The roles of nuclear transcription factors in calcium homeostasis

1997 - 1999 Application of Hedgehog Proteins as Drugs for Induction of Hard Tissues and Repair of Hard Tissue Defects.

1997 - 1999 Studies on Clarification of Pathological Conditions of Osteoporosis in the Ora

1998 - 1998 骨形成機構の細胞生物学・分子生物学的解析

1997 - 1998 Role of hedgehogs in differentiation of cultured osteoblasts

1997 - 1998 Development of a therapeutic method of bone repair using BMP responding mesencbymal cells

1997 - 1998 Morphological and molecular analyses of bone repair

1997 - 1997 骨形成機構の細胞生物学的・分子生物学的解析

1995 - 1997 Establishment of assay systems for examining bone metabolism : Studies on differentiation and function of osteoblasts and osteoclasts

1996 - 1996 骨芽細胞の放射線感受性に及ぼす多因子の相関

1995 - 1996 Role of BMP in fracture repair

1994 - 1996 Role of BMPs in differentiation process of osteoblasts, chondrocytes and muscle cells

1995 - 1995 オステオポンチン遺伝子導入トランスジェニックマウスの解析

1993 - 1995 Development of reliable screening systems for drugs which regulate bone resorption : In vitro assay systems for osteoclast formation and function.

1994 - 1994 骨組織薄切切片を用いた器官培養系の確立

1993 - 1994 Study for differentiation process of osteoblasts

1993 - 1993 成熟骨組織中で骨芽細胞の新生を促す因子に対する受容体遺伝子を、形態学的に探し出す

1992 - 1993 Investigation of mechanism of bone formation associated with aging

1991 - 1993 Development and its application of simple methods for bone sections

1989 - 1991 Establishment of the screening methods for bone-resorbing factors using in vitro osteoclast formation system.

1990 - 1990 破骨細胞の分化段階および活性状態の組織化学的方法による解明

1989 - 1990 Establishment of Assay System for Studying Osteoblastic Function and Differentiation Using Newly Isolated Osteoblast-Like Cell Lines

1989 - 1990 Molecular Biological and Immunohistochemical Study of Differentiation of the Osteoblast.

1988 - 1989 Role of the osteoclast and osteoblast during the bone resorption

1988 - 1989 Production and characterization of monoclonal antibodies that react with osteoblasts

脊椎動物の進化における骨格形成の変遷

癌による骨破壊のメカニズム

口腔疾患の臨床病理学的研究

骨形成・骨再生の分子メカニズム

Development of new therapy for bone regeneration

Development of new drugs for osteoporosis

Bove cell Biology

Oral Pathology

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Papers (300)：

Yutaro Ando, Masayuki Tsukasaki, Nam Cong-Nhat Huynh, Shizao Zang, Minglu Yan, Ryunosuke Muro, Kazutaka Nakamura, Masatsugu Komagamine, Noriko Komatsu, Kazuo Okamoto, et al. The neutrophil-osteogenic cell axis promotes bone destruction in periodontitis. International journal of oral science. 2024. 16. 1. 18-18
Hiroyuki Ogura, Takashi Nakamura, Takenobu Ishii, Akiko Saito, Shoko Onodera, Akira Yamaguchi, Yasushi Nishii, Toshifumi Azuma. Mechanical stress-induced FGF-2 promotes proliferation and consequently induces osteoblast differentiation in mesenchymal stem cells. Biochemical and biophysical research communications. 2023. 684. 149145-149145
溝口利英, 澁川義幸, 大野建州, 菅原圭亮, 山口朗. 「東京歯科大学研究プロジェクトからの情報発信」新たな研究プロジェクト「各ライフステージにおける口腔顎顔面機能維持・改善で目指すウェルビーイング社会の実現(ウェルビーイングプロジェクト)」の概要紹介. 歯科学報. 2023. 123. 2. 73-82
Shinichirou Ito, Norio Kasahara, Kei Kitamura, Satoru Matsunaga, Toshihide Mizoguchi, Myo Win Htun, Yasuaki Shibata, Shinichi Abe, Masayuki Takano, Akira Yamaguchi. Pathological differences in the bone healing processes between tooth extraction socket and femoral fracture. Bone reports. 2022. 16. 101522-101522
Kazuto Koresawa, Satoru Matsunaga, Atsuhiko Hikita, Hajime Okudera, Akira Yamaguchi, Yasutomo Yajima, Shinichi Abe. Micro/nanostructural properties of peri-implant jaw bones: a human cadaver study. International journal of implant dentistry. 2022. 8. 1. 17-17

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MISC (104)：

伊藤慎一郎, 笠原典夫, 北村啓, 松永智, 溝口利英, 笠原正貴, 山口朗. Skeleton-dependent stem cell diversity explored from the healing process of extraction sockets and femoral bone defects. Journal of Oral Biosciences Supplement (Web). 2022. 2022
小倉弘之, 中村貴, 石井武展, 齋藤暁子, 小野寺晶子, 山口朗, 末石研二, 西井康, 東俊文. Apert症候群における頭蓋縫合早期癒合メカニズムの解明. 歯科学報. 2021. 120. 4
東俊文, 中村貴, 中村貴, 斎藤暁子, 斎藤暁子, 小野寺晶子, 小野寺晶子, 末石研二, 長山和亮, 山口朗. ラミノパチーとしての鎖骨頭蓋骨異形成症病態解明から新奇薬剤治療法開発への展開. 日本再生医療学会総会(Web). 2019. 18th
山口朗, 東俊文, 東俊文, 石原和幸, 片倉朗, 後藤多津子, 齋藤淳, 澁川義幸, 新谷誠康, 新谷誠康, et al. 顎骨疾患プロジェクトの現状と今後の展望. 歯科学報. 2017. 117. 4. 271-279
東俊文, 東俊文, 小野寺晶子, 小野寺晶子, 小野寺晶子, 齋藤暁子, 齋藤暁子, 中村貴, 中村貴, 大庭伸介, et al. iPS細胞を用いた顎骨疾患病態解明へのアプローチ. Journal of Oral Biosciences Supplement (Web). 2017. 2017

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Books (1)：

The role of BMP-2 in the olipperentiation of skeletal mesenclymal cells.
Biological mechanisms of footh movement and craniofacial adaptation 1996

Works (4)：

骨再生における力学的負荷の役割の解析
2001 -
骨芽細胞の分化に及すリゼトロネートの作用
2001 -
Role of mechanical loading on bone regeneration
2001 -
Effects of Risedronate on osteoblast differentiation
2001 -

Education (3)：

- 1980 Tokyo Medical and Dental University
- 1980 Tokyo Medical and Dental University Graduate School, School of Dentistry School of Dentistry
- 1974 Tokyo Dental College Faculty of Dentistry

Professional career (1)：

- (Tokyo Medical and Dental University)

Work history (8)：

2016/04 - 現在 Meikai University
2015 - 現在 Tokyo Dental College Oral Health Science Center Professor
2011/04 - 現在 Showa University
2013/04 - 2015/03 東京医科歯科大学歯学部附属病院検査部部長
2004/04 - 2015/03 - 東京医科歯科大学大学院医歯学総合研究科教授

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Committee career (11)：

2017/10 - 2021/09 日本学術会議連携会員
2011/10 - 2017/09 日本学術会議会員
2011 - 2015 日本口腔腫瘍学会理事
2012 - 2014 日本臨床口腔病理学会理事長
2008 - 2014 日本病理学会理事

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Awards (6)：

2017 - 日本骨代謝学会学会賞
2015 - 日本歯科医学会会長賞
2005 - 日本病理学会賞
1997 - 昭和大学上條奨学賞研究補助
1996 - 日本病理学会学術研究賞

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Association Membership(s) (8)：

日本分子生物学会 , 日本口腔病理学会 , 日本発生生物学会 , American Society of Bone and Mineral Research , 日本骨形態計測学会 , 歯科基礎医学会 , 日本病理学会 , 日本骨代謝学会

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