TAGUCHI SEIICHI

Affiliation and department：
Job title： Professor

Research field (1)： Applied microbiology

Research keywords (3)：応用微生物学 , 高分子化学 , 生物機能・バイオプロセス

Research theme for competitive and other funds (21)：

2019 - 2023 Biosynthesis of chiral polymer with stereochmical reversion
2017 - 2020 Creation of new biodegradability controlled plastics based on the degradation mechanism
2014 - 2017 Efficient production of high optical pure hydroxy acid based on the regeneration of coenzyme A
2014 - 2017 Microbial production of elastic polymers with ordered structure
2014 - 2016 Evolutionary engineering of microbial enzyme that regulates the monomer composition in lactate-based polymer

2012 - 2014 Evolutionary engineering based creation of monomer-supplying enzyme that allows the microbial synthesis of new monomer-incorporated polymers

2011 - 2014 Establishment of the next generation microbial factory for lactate-based polymers by utilizing biomass

2011 - 2013 Development of microbial factory for bioplastic production adapting inedible biomass hydrolysates

2010 - 2011 Creation of biocatalyst capable of biosynthesizing lactate-based polymers with highly regulated chirality

2008 - 2010 Establishment of the all biosynthetic system for new monomers-contained biopolymers as a basis for enzyme evolutionary engineering

2005 - 2007 Prroduction System for Carbon Recyclable Green Plastics Based on Enzyme Evolutionary Engineering

2006 - 2006 次世代バイオベースプラスチックの創成とナノ構造制御による高機能化

2002 - 2004 Oprimization of production system for bioplastics by enzyme evolutionary engineering

1998 - 1999 Cold adaptation of enzymes by means of evolutionary and protein engineering

1998 - 1999 分化微生物プロテアーゼインヒビターと多様な酵素群とのコミュニケーション

1995 - 1997 Experimental evolution of apidaecin of honey bee origin as a model of antimicrobial peptides

1996 - 1996 単純分化微生物のプロテアーゼ・インヒビター間コミュニケーション

1995 - 1995 単純分化モデル放線菌におけるプロテアーゼ・インヒビター相互作用系

1994 - 1994 SSI様インヒビター群と真の標的酵素群の相互作用ならびに生理的意義

1992 - 1994 Genetic Studies on Cold-adapted Enzymes

1993 - 1993 放線菌に高頻度出現するSSI様プロテアーゼヒビターの生理的意義の解明

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Papers (317)：

Sangho Koh, Michio Sato, Hiromi Matsusaki, Seiichi Taguchi. The Discovery of Membrane Vesicle Biogenesis in the Polyhydroxybutyrate-non-producing Mutant Strain of Cupriavidus necator H16. Microbes and environments. 2024. 39. 3
Ryosuke Kadoya, Hitomi Soga, Miki Matsuda, Michio Sato, Seiichi Taguchi. Bacterial Population Changes during the Degradation Process of a Lactate (LA)-Enriched Biodegradable Polymer in River Water: LA-Cluster Preferable Bacterial Consortium. Polymers. 2023. 15. 20
Yuki Nagao, Sangho Koh, Seiichi Taguchi, Tomohiro Shimada. Cell-growth phase-dependent promoter replacement approach for improved poly(lactate-co-3-hydroxybutyrate) production in Escherichia coli. Microbial cell factories. 2023. 22. 1. 131-131
Ramamoorthi M Sivashankari, Maierwufu Mierzati, Yuki Miyahara, Shoji Mizuno, Christopher T Nomura, Seiichi Taguchi, Hideki Abe, Takeharu Tsuge. Exploring Class I polyhydroxyalkanoate synthases with broad substrate specificity for polymerization of structurally diverse monomer units. Frontiers in bioengineering and biotechnology. 2023. 11. 1114946-1114946
Lucas Vinicius Santini Ceneviva, Maierwufu Mierzati, Yuki Miyahara, Christopher T Nomura, Seiichi Taguchi, Hideki Abe, Takeharu Tsuge. Poly(3-mercapto-2-methylpropionate), a Novel α-Methylated Bio-Polythioester with Rubber-like Elasticity, and Its Copolymer with 3-hydroxybutyrate: Biosynthesis and Characterization. Bioengineering (Basel, Switzerland). 2022. 9. 5

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MISC (447)：

門屋亨介, 曽我瞳, 松田美樹, 佐藤道夫, 田口精一. Effects of LAHB degradation in the water environment on bacterial communities. 日本生物工学会大会講演要旨集. 2023. 75th
KOH Sangho, 田口精一, 田口精一. メンブレンベシクル創発の新原理バイオプラスチック合成が”引き金”. 化学と生物. 2023. 61. 5
長尾優輝, 高相昊, 田口精一, 島田友裕. プロモーター置換法による進化型ポリ乳酸の生産性向上. 日本農芸化学会関東支部講演要旨集(CD-ROM). 2023. 2023
門屋亨介, 曽我瞳, 松田美樹, 田口精一. Effect of bacterial flora in river water samples on the degradation of the biodegradable bioplastic LAHB. 日本農芸化学会大会講演要旨集(Web). 2023. 2023
KOH Sangho, 今井祐介, 冨永雄一, 田中真司, 吉田勝, 古舘祥, 佐藤俊輔, 田口精一. Microbial production of lactate (LA)-based polymers varying LA fractions aimed to optimize mechanical performance upon blending with PLA. 日本農芸化学会大会講演要旨集(Web). 2023. 2023

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Books (63)：

「バイオリアクターのスケールアップと物質生産事例集」:乳酸ポリマーP(LAHB)の微生物生産
NTS出版 2021
非天然型ポリヒドロキシアルカン酸の分解性とその評価方法
シーエムシー 2019
多元ポリ乳酸:生分解性バイオマスプラスチックの食品包装材への展開
包装食品技術協会誌「食品の包装」特集:バイオプラスチック 2019
「オリゴマー」が鍵:バイオプラスチックの生合成と生分解
エヌティーエス 2019
多元ポリ乳酸の合成/分解の交差点:「オリゴマー」
シーエムシー 2019

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Lectures and oral presentations (72)：

Synthetic biology for bioplastics = Biosynthesis x Polymer Chemistry (Invited Lecture)
(Technical Seminar 2019)
Biodegradable and biocompatible polymers biosynthesized by sustainable integrated bioprocess (Plenary Lecture)
(10th Edition of International Conference on Biofuels and Bioenergy, Barcelona, Spain 2019)
多元ポリ乳酸を細胞培養基材とした軟骨組織形成(招待講演)
(第5回生命理工オープンイノベーションハブ(LiHub)、東京工業大学大岡山キャンパス、蔵前会館、ロイヤルブルーホール 2018)
環境生体に調和するバイオプラスチックの合成生物学と機能部材化(招待講演)
(群馬大学(招待講演)、群馬大学総合研究棟303教室(S303) 2018)
Biodegradable and biocompatible polymers biosynthesized by microbial platform from renewable feedstock (Invited Lecture)
(BIT’s 9th World Gene Conversion-2018, Singapore 2018)

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