Rchr
J-GLOBAL ID：200901043150844427   Update date: Aug. 23, 2024

Shirasawa Senji

シラサワ センジ | Shirasawa Senji
Affiliation and department：
Fukuoka University Faculty of Medicine, School of Medicine

About Fukuoka University Faculty of Medicine, School of Medicine


Homepage URL  (1)： http://www.med.fukuoka-u.ac.jp/cellbio/index-j.html
Research field  (4)： Experimental pathology ,  Medical biochemistry ,  Molecular biology ,  Cell biology
Research keywords  (7)： obesity & diabetes mellitus ,  ZFAT ,  hematopoietic cell differentiation ,  T cell differentiation ,  KRAS ,  colorectal cancer ,  Molecular carcinogenesis
Research theme for competitive and other funds  (30)：
  • 2021 - 2024 Control of KRAS signals in cancer-immune microenvironment
  • 2018 - 2021 Elucidation of in vivo-like signal regulated by mutated KRAS in colorectal cancer spheroid and development of inhibitor.
  • 2015 - 2018 Elucidation of the mechanism for regulating microenvironment and cancer development by mutant KRAS
  • 2012 - 2015 Analyse of peripheral secreted microRNA controlled by mutations KRAS in lung cancer.
  • 2012 - 2015 Elucidation of the transcription factor Zfat function in the immune system using a conditional knockout mouse model
Show all
Papers (195)：
  • Takanori Kitaguchi, Taichi Matsumoto, Kazumasa Yoshida, Yuriko Hamaguchi, Gen Maruta, Hisanori Maeoka, Shuhei Ishikura, Michitaka Nakano, Yusuke Ishida, Fumihito Hirai, et al. Inhibitory Effect of Pyra-Metho-Carnil on the Differentiation and Maturation of Macrophages in Normal and Cancer Microenvironments. Anticancer research. 2024. 44. 8. 3557-3565
  • KAZUMASA YOSHIDA, KENSUKE NISHI, SHUHEI ISHIKURA, TAICHI MATSUMOTO, KAZUHIKO NAKABAYASHI, RYO YAZAKI, TAKASHI OHSHIMA, MASAHIKO SUENAGA, SENJI SHIRASAWA, TOSHIYUKI TSUNODA. Inhibitory Effect of Pyra-Metho-Carnil on Cancer Spheroid Growth Through Decrease in Glycolysis-associated Molecules. Anticancer Research. 2023. 43. 8. 3717-3726
  • Shuhei Ishikura, Kazumasa Yoshida, Toshiyuki Tsunoda, Senji Shirasawa. Death domain-associated protein DAXX regulates non-coding RNA transcription at the centromere through the transcription regulator ZFAT. The Journal of biological chemistry. 2022. 298. 11. 102528-102528
  • Tokio Terado, Chul Jang Kim, Akiyo Ushio, Kahori Minami, Yukihiro Tambe, Susumu Kageyama, Akihiro Kawauchi, Toshiyuki Tsunoda, Senji Shirasawa, Hiroyuki Tanaka, et al. Cryptotanshinone suppresses tumorigenesis by inhibiting lipogenesis and promoting reactive oxygen species production in KRAS-activated pancreatic cancer cells. International journal of oncology. 2022. 61. 3
  • Kensuke Nishi, Shohei Yoshimoto, Soichiro Nishi, Tatsuro Nishi, Ryushiro Nishi, Takayuki Tanaka, Toshiyuki Tsunoda, Kazuaki Imai, Hiroaki Tanaka, Osamu Hotta, et al. Epipharyngeal Abrasive Therapy (EAT) Reduces the mRNA Expression of Major Proinflammatory Cytokine IL-6 in Chronic Epipharyngitis. International journal of molecular sciences. 2022. 23. 16
ｍore...
MISC (5)：
  • 石倉 周平, 中林 一彦, 白澤 専二. Znフィンガータンパク質Zfatのセントロメアへの局在. 日本生化学会大会プログラム・講演要旨集. 2018. 91回. [1P-241]
  • 澤田 悠賀, 松川 泰治, 土井 聡, 角田 俊之, 岡本 春奈, 苗村 円佳, 田原 圭一郎, 有川 和沙, 松岡 耕平, 原田 正樹, et al. 新規レスベラトロール誘導体は大腸癌細胞三次元増殖を抑制する. 生命科学系学会合同年次大会. 2017. 2017年度. [3P-1297]
  • Shirasawa S, Nabeshima K, Kuroki M, Tachibana K, Yamashita Y, Sakisaka S, Iwamoto T, Saku K, Hiromatsu K, Saito T, et al. Targeting of gene therapy for gastrointestinal cancer by using anti-tumor antibodies (in Japanese). MEXT-Supported Program for the Strategic Research Foundation at Private Universities: Central Research Institute for Advanced Molecular Medicine, Fukuoka University - Overview Reports. 2013. 1. 1. 107-181
  • Shirasawa S, Nabeshima K, Kuroki M, Tachibana K, Yamashita Y, Sakisaka S, Iwamoto T, Saku K, Hiromatsu K, Saito T, et al. Analysis of etiology and pathogenesis of cancer, lifestyle-related diseases, and immune-related diseases and development of molecular targeted therapy for them: targeting of gene therapy for gastrointestinal cancer by using anti-tumor antibodies (in Japan. Annual Reports of Central Research Center for Advanced Molecular Medicine, Fukuoka University. 2011. 1. 1. 53-108
  • Hirotoshi Kikuchi, Maria S. Pino, Min Zeng, Senji Shirasawa, Hiroyuki Konno, Daniel C. Chung. Translational regulation of hypoxia-inducible factor-1 alpha and 2 alpha by mutant oncogenes in colon cancer. CANCER RESEARCH. 2010. 70
Patents (5)：
  • ZFAT遺伝子発現制御RNA
  • 白血病治療用医薬組成物
  • イノシトール-1,4,5-トリスリン酸受容体結合タンパク質およびそれを含むトランスジェニック非ヒト哺乳動物
  • エピレグリン遺伝子欠損動物およびその利用方法
  • KRAP遺伝子変異による脂質代謝および糖代謝改変動物、改変方法および改変剤
Education (2)：
  • Kyushu University Faculty of Medicine
  • Kyushu University Graduate School, Division of Medical Sciences
Professional career (2)：
  • 医学博士 (九州大学)
  • M.D.Ph.D. (Kyushu University)
Work history (5)：
  • 2006/04 - 福岡大学医学部細胞生物学 教授
  • 2001/04 - 2006/03 国立国際医療センター研究所臨床病理研究部 部長
  • 1996/04 - 2001/03 Dept. Genet. Med. Inst. of Bioreg., Kyushu Univ., Research Assistant
  • 1993/10 - 1996/03 Research Associate, HHMI, Washington Univ., School of Med.
  • 1987/04 - 1989/03 Resident, Kyushu Univeristy Hospital
Association Membership(s) (2)：
バイオ治療法研究会 ,  日本癌学会
※ Researcher’s information displayed in J-GLOBAL is based on the information registered in researchmap. For details, see here.

Return to Previous Page

TOP

BOTTOM