Kimura Tominori

キムラトミノリ | Kimura Tominori

Research field (4)： Allergies and connective tissue disease , Virology , Cell biology , Molecular biology

Research keywords (1)： Molecular cell biology, Virology, Microbiology, Infectious Diseases (Nosocomial infections in particular)

Research theme for competitive and other funds (8)：

2013 - 2014 非コード性RNAに由来する核酸医薬シーズと生分解性ナノ粒子DDSの一体開発による革新的抗インフルエンザ予防・治療薬の創出
2011 - 2011 モルモットインフルエンザモデルによるインターフェロン-αモジュレーターの抗ウイルス活性の評価
2009 - 2009 内因性アンチセンスRNAによるインターフェロン-αの発現調節機能の評価
2007 - 2007 新規RNA核外輸送因子による抗ウイルス性自然免疫調節作用の評価
2003 - 2003 新スペクトラムを有する抗HIV-1薬の開発とウイルス感染調節機構のウイルス学的創薬化学的解析

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Papers (18)：

Tokifumi Odaka, Ryou Sakamoto, Kazuhiro Kumagai, Kazu Okuma, Mikio Nishizawa, Tominori Kimura. Ephrin type-A receptor 2-antisense RNA1/2 promote proliferation and migration of MDA-MB-231 cells through EPHA2-dependent Ras signaling pathway mediated by MAPK8/JNK1, MAPK9/JNK2-NFATC2/NFAT1 and JUND. Frontiers in Molecular Biosciences. 2024. 11
Shiwen Jiang, Ryou Sakamoto, Tominori Kimura. A guinea pig IFNA1 gene with antiviral activity against human influenza virus infection. Frontiers in Bioscience (Landmark edition). 2019. 24. 4. 790-797-797
Ryou Sakamoto, Shiwen Jiang, Yusuke Tsukamoto, Hiroyuki Tsujimoto, Tominori Kimura. IFN-Alpha1 antisense RNA represses human influenza A virus growth in a guinea pig system. Frontiers in Bioscience (Landmark edition). 2019. 24. 4. 798-818-818
Souichi Oe, Tominori Kimura, Hisao Yamada. Regulatory non-coding RNAs in neuronal development and disease. Frontiers in Bioscience (Landmark Edition). 2019. In press
Noriyuki Yoshida, Tominori Kimura. Pathogen-associated regulatory non-coding RNAs and oncogenesis. FRONTIERS IN BIOSCIENCE-LANDMARK. 2017. 22. 1599-1621

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MISC (5)：

Mikio Nishizawa, Tominori Kimura. RNA networks that regulate mRNA expression and their potential as drug targets. RNA & Disease. 2016. 3. e864
蒋時文, 吉開会美, 西澤幹雄, 中村紳一郎, 木村富紀. センダイウイルスにより誘導される内因性アンチセンスRNAによるヒトインターフェロン-α1遺伝子の転写後性発現調節. 日本ウイルス学会学術集会プログラム・抄録集. 2012. 60th
Tominori Kimura, Jiang Shiwen, Mikio Nishizawa, Emi Yoshigai, Iwao Hashimoto. Stabilisation of human interferon-alpha 1 mRNA by its antisense RNA. CYTOKINE. 2011. 56. 1. 5-5
Tominori Kimura, Jiang Shiwen, Mikio Nishizawa, Masao Nishikawa. A natural antisense transcript of interferon-alpha 1 gene regulates viral infection-mediated mRNA expression level and further induction of interferon-alpha 1 protein. CYTOKINE. 2009. 48. 1-2. 124-124
Tamura Satoru, Shiomi Atsushi, Todo S., Kaneko Masafumi, Shioda Tatsuo, Kimura Tominori, Yoshida Minoru, Nagata Naoya, Nakanishi Isao, Kitaura Kazuo, et al. P-5 Exploration of New Anti-HIV Leads Inhibiting Nuclear Export of Rev Protein on the Basis of Mechanism of Action. Symposium on the Chemistry of Natural Products, symposium papers. 2006. 48. 253-258

Patents (3)：

インターフェロン-α発現調節剤
Interferon-alpha modulater
呼吸器ウイルス感染症の予防・治療剤

Books (5)：

AHCC 臨床ガイドブック
International Congress on Nutritional and Integrative Medicine 2017 ISBN:9784898015858
Clinician's guide to AHCC: evidence-based nutritional immunotherapy
International Congress on Nutrition and Integrative Medicine 2016 ISBN:9784990926403
スタンダード薬学シリーズII: 第4巻生物系薬学 III生体防御と微生物(日本薬学会編)
東京化学同人 2016 ISBN:9784807917105
Life Science 1-From Individual To Molecule- ・3.2 Infectious Diseases
CORONA PUBLISHING CO., LTD. 2012
『KEY WORD 感染症第2版』54. rev 遺伝子
先端医学社 2008

Lectures and oral presentations (37)：

Interferon-alpha1 antisense RNA modulates levels of interferon-alpha1 mRNA expression and antagonizes proliferation of human influenza A virus in a guinea pig model system
(RNA Therapeutics Conference 2018: From Base Pairs to Bedsides 2018)
Active Hexose Correlated Compound suppressed the proliferation of human breast cancer cells at least by reducing EphA2 antisense RNA, and mRNA expression levels
(The 39th annual meeting of the Molecular Biology Society of Japan 2016)
Effect of AHCC on metastatic mammary carcinoma-derived MDA-MB-231 cell proliferation and EphA2 gene expression that affects the tumor cell growth
(The 24th annual meeting of International Congress on Nutrition and Integrative Medicine 2016)
乳癌培養細胞並びに組織で同定したEphA2アンチセンスRNAの解析
(第38回日本分子生物学会年会/ 第88回日本生化学会大会合同大会 2015)
Natural antisense RNA-based oligoribonucleotide therapeutics for Influenza virus infection
(日本核酸医薬学会第1回年会 2015)

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Works (4)：

Catching the common cold
2013 -
User Applications, Suspension cells/B-lymphoblastoid cells (Namalwa)
2013 -
Featured article: stabilization of human interferon-{Alpha}1 mRNA by its antisense RNA.
2013 -
Regulatory RNA (A special issue to Frontiers in Bioscience as a managing editor; http://www.bioscience.org/special-issue-details?editor_id=193
2012 -

Education (2)：

- 1985 Kansai Medical University Graduate School, Division of Medicine Microbiology
- 1980 Kansai Medical University Faculty of Medicine Department of Medicine

Professional career (1)：

Doctor of Medical Sciences (Kansai Medical University)

Work history (2)：

2010/04/01 - Shiga University of Medical Science
2007/04/01 - Kansai Medical University

Committee career (8)：

2013/10 - 2015/10 茨木市新型インフルエンザ等対策審議会茨木市新型インフルエンザ等対策審議会委員、会長
2014/05 - 2015/03 草津市新型インフルエンザ等対策有識者会議草津市新型インフルエンザ等対策有識者会議委員
2013/10 - 2013/10 日本ウイルス学会第61回日本ウイルス学会学術集会プログラム委員
2013/05 - 日本臨床分子形態学会評議員
2012/10 - 2012/10 日本ウイルス学会第60回日本ウイルス学会学術集会プログラム委員

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Awards (2)：

2010/09 - 第42回日本臨床分子形態学会論文賞
1984/04 - The British Council Scholarship (84/85 JPN/2201/268)

Association Membership(s) (9)：

The International Cytokine & Interferon Society , The American Society for Cell Biology , Society for General Microbiology , Japanese Society for Bacteriology , The Japanese Society for Clinical Molecular Morphology , The Pharmaceutical Society of Japan , The RNA Society of Japan , The Molecular Biology Society of Japan , The Japanese Society for Virology

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