NAKAGAWA Hidehiko

ナカガワヒデヒコ | NAKAGAWA Hidehiko

Affiliation and department：
Job title： Professor
Homepage URL (1)： http://www.phar.nagoya-cu.ac.jp/hp/ykg/Yakka/index.html

Research field (2)： Chemical biology , Pharmaceuticals - chemistry and drug development

Research keywords (6)： medicinal chemistry , chemical probe , caged compunds , reactive oxygen species , nitric oxide , 包括脳ネットワーク

Research theme for competitive and other funds (27)：

2023 - 2026 Development of near-infrared light-responsive flexible nitric oxide-emitting nanomaterials.
2021 - 2026 In-cell chemistry of supersulfur species in biology
2021 - 2026 Management of international relation and facility for promotion of research on sulfur biology
2021 - 2024 Application of light-controllable nitric oxide donor for lower urinary tract symptom
2020 - 2023 光制御可能なNOドナー「NORD-1」の難治性EDへの応用

2019 - 2023 Fluorescent imaging probes for epigenetic enzymes with specialized amino acids

2019 - 2022 Caged compounds for NO and its related signaling molecules with multimodal control, and their biological applications

2016 - 2019 Expanded chemical properties of novel caged NOs and biological applications

2015 - 2019 Promotion of oxygen biology on the basis of international networks

2014 - 2019 Oxygen biology: a new criterion for integrated understanding of life

2014 - 2019 Development of imaging probes and caged compounds for oxygen biology researches

2016 - 2018 The development of a novel ED therapy by four-dimensional controllable NO releasers

2016 - 2018 New fluorescence NO probe adopting radical-specific reactivity

2014 - 2016 Molecular design of Pin1-binding fluorescence probes for efficient drug screening

2013 - 2016 Photocontrol of NO and H2S treatment as signaling molecules and biological applications

2012 - 2015 Synthesis of HDAC inhibitors that locally develop their inhibition activity in cells

2013 - 2014 Development of peptidyl prolyl isomerase Pin1 inhibitors based on thioamide isomerization energy

2011 - 2013 活性酸素シグナル解明のための光制御ピンポイントNO類ドナー

2010 - 2012 Oxidative stress imaging in organelle by novel TEMPO derivatives

2009 - 2011 活性酸素シグナル解明のためのピンポイントNO類ドナー

2008 - 2011 Development of drug candidates that epigenetically regulate gene expression

2005 - 2008 Oxidative degeneration of neurodegenerative disease-related protein and reactive nitrogen oxide stress

2002 - 2005 Development of novel oxyl-radical quenching pharmacophores as drug candidates

2001 - 2002 パーオキシナイトライトによるシトクロムC修飾作用のアポトーシス様細胞死への関与

2001 - 2002 Study on Development of Redox Regulatative Substances Against Oxidative Stress.

1999 - 2000 パーオキシナイトライトのシトクロムc修飾反応とミトコンドリア活性・細胞障害作用

1999 - 2000 Study on Development of Bioregurative Substances Related with Generation and Elimination for Active Oxygen and Nitrogen Species.

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Papers (149)：

Mitsuyasu Kawaguchi, Shohei Minami, Naoya Ieda, Hidehiko Nakagawa. [1,2,4]Triazolo[1,5-a]pyrimidine derivatives: Structure-activity relationship study leading to highly selective ENPP1 inhibitors. Bioorganic & Medicinal Chemistry Letters. 2024. 110. 129820-129820
Yuji Hotta, Kyoya Oyama, Takuma Yoshida, Naoya Ieda, Taiki Mori, Yasuhiro Horita, Tomoya Kataoka, Yoko Furukawa-Hibi, Susumu Ohya, Hidehiko Nakagawa, et al. The Effects of a Red-Light Controllable Nitric Oxide Donor, NORD-1, on Erectile Dysfunction in Rats with Streptozotocin Induced Diabetes Mellitus. The World Journal of Men's Health. 2024. 42
Naoya Ieda, Akira Nakamura, Natsumi Tomita, Kei Ohkubo, Ryo Izumi, Yuji Hotta, Mitsuyasu Kawaguchi, Kazunori Kimura, Hidehiko Nakagawa. A BODIPY-picolinium-cation conjugate as a blue-light-responsive caged group. RSC Advances. 2023. 13. 26375-26379
Naoya Ieda, Mitsuyasu Kawaguchi, Hidehiko Nakagawa. Substituent Effects at the <i>N</i>-Nitrosoaminophenol Moiety of a Photoinduced-Electron-Transfer-Driven Nitric Oxide Releaser. Chemical and Pharmaceutical Bulletin. 2023. 71. 6. 447-450
Naoya Ieda, Masato Sawada, Runa Oguchi, Masato Itoh, Seina Hirakata, Daisuke Saitoh, Akito Nakao, Mitsuyasu Kawaguchi, Kazunobu Sawamoto, Toshitada Yoshihara, et al. An Optochemical Oxygen Scavenger Enabling Spatiotemporal Control of Hypoxia. Angewandte Chemie International Edition. 2023. 62. 20

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MISC (63)：

坂本眞伍, 小松徹, 渡邉力也, 張翼, 井上大輝, 川口充康, 中川秀彦, 植野高章, 奥坂拓志, 本田一文, et al. 1分子酵素活性プロファイリング技術のリキッドバイオプシーへの応用. JSMI Report. 2021. 14. 2. 135-135
坂本眞伍, 小松徹, 渡邉力也, 張翼, 井上大輝, 川口充康, 中川秀彦, 植野高章, 奥坂拓志, 本田一文, et al. 1分子酵素活性プロファイリング技術のリキッドバイオプシーへの応用. JSMI Report. 2021. 14. 2. 135-135
山口遥己, 川口充康, 井田智章, 松永哲郎, 家田直弥, 赤池孝章, 中川秀彦. S-sulfhydryl化タンパク質解析を志向したhydropersulfideラベル化蛍光プローブの開発. 日本病院薬剤師会東海ブロック・日本薬学会東海支部合同学術大会講演要旨集. 2021. 2021
Naoya Ieda, Hidehiko Nakagawa. Development of Photoredox-reaction-driven NO-releasing Reagents and Application for Photomanipulation of Vasodilation. Yuki Gosei Kagaku Kyokaishi/Journal of Synthetic Organic Chemistry. 2020. 78. 11. 1048-1057
坂本眞伍, 小松徹, 渡邉力也, 張翼, 井上大輝, 川口充康, 中川秀彦, 植野高章, 奥坂拓志, 本田一文, et al. 1分子酵素活性プロファイリングによる疾患関連酵素の超高感度検出. 日本生化学会大会(Web). 2020. 93rd. 1. 39-42

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Lectures and oral presentations (21)：

ENPP1活性検出蛍光プローブの開発とケミカルスクリーニング
(メディシナルケミストリーシンポジウム講演要旨集 2017)
Inhibition of Amyloid-beta Fibril Formation and Its Cytotoxicity by Antioxidant-Conjugated Amyloid-beta C-Terminal Peptides
(FREE RADICAL BIOLOGY AND MEDICINE 2016)
Chamical Biology for Pharmaceutical Sciences-Novel Approaches for Exploring Cellular Functions with Non-drug Chemicals Foreword
(YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN 2016)
Photo-manipulation of vasodilation with a novel photo-controllable nitric oxide releaser based on N-nitrosoaminophenol
(NITRIC OXIDE-BIOLOGY AND CHEMISTRY 2014)
Hydrogen sulfide releaser with xanthone-type photocages
(NITRIC OXIDE-BIOLOGY AND CHEMISTRY 2014)

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Education (2)：

1990 - 1995 The University of Tokyo Graduate School of Pharmaceutical Sciences
1986 - 1990 The University of Tokyo Faculty of Pharmaceutical Sciences

Professional career (1)：

Ph.D.

Work history (10)：

2013/04 - 現在 Nagoya City University Graduate School of Pharmaceutical Sciences
2010/10 - 2014/03 科学技術振興機構兼任研究員(さきがけ)
2007/04 - 2013/03 Nagoya City University Graduate School of Pharmaceutical Sciences
2004/05 - 2007/03 Nagoya City University Graduate School of Pharmaceutical Sciences
2000/04 - 2004/04 放射線医学総合研究所主任研究員

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Committee career (1)：

2017/10 - 現在 World Health Organization International Non-proprietary Names (INN) Expart

Awards (2)：

2016/03 - Pharmaceutical Society of Japan Award for Divisional Scientific Promotion
2014 - Society for Free Radical Research Japan Award for Scientific Promotion

Association Membership(s) (5)：

THE JAPANESE PHOTOCEHMISTRY ASSOCIATION , THE SOCIETY OF ELECTRON SPIN SCIENCE AND TECHNOLOGY , SOCIETY FOR FREE RADICAL RESEARCH JAPAN , THE PHARMACEUTICAL SOCIETY OF JAPAN , The Chemical Society of Japan

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