Rchr
J-GLOBAL ID：200901043728709080
Update date: Aug. 25, 2024
Watanabe Bunta
ワタナベ ブンタ | Watanabe Bunta
Affiliation and department：
Job title：
Associate Professor
Homepage URL (1)：
http://www.jikei.ac.jp/academic/course/35_sizenkagaku.html
Research field (1)：
Bioorganic chemistry
Research keywords (5)：
synthetic organic chemistry
, natural product chemistry
, bioorganic chemistry
, plant secondary metabolites
, plant hormones
Research theme for competitive and other funds (8)：
- 2022 - 2026 Study on biosynthesis of steroidal glycoalkaloids in Solanaceae plants based on organic synthetic chemistry
- 2019 - 2023 植物「嗅覚(揮発性化合物を認識し生体シグナルへと変換する過程)」の解明
- 2015 - 2017 Synthesis of gamma-glutamyl transpeptidase-specific chemical probes and their application to cancer immunotherapy
- 2013 - 2016 Elucidation of Multidrug recognition mechanism of ABC transporter and development of its novel inhibitor
- 2013 - 2015 Study on the biosynthesis and the dynamics of archaeal membrane lipids using synthetic lipid probes
- 2011 - 2013 Drug design based on asparagine synthetase inhibitors
- 2009 - 2010 Development of novel regulators for controlling glutathione biosynthesis
- 2007 - 2009 Development of chemicals that control the glutathione metabolism and oxidative stress and their use for chemical biology
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Papers (64)：
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Ken’ichiro Hayashi, Masaaki Kobayashi, Kotaro Mori, Yoshiaki Nakagawa, Bunta Watanabe, Atsushige Ashimori, Fumiaki Higashijima, Takuya Yoshimoto, Junki Sunada, Tsuyoshi Morita, et al. The benzoylphenylurea derivative BPU17 acts as an inhibitor of prohibitin and exhibits antifibrotic activity. Experimental Cell Research. 2024. 114221-114221
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Kohei Nakanishi, Hao Li, Takuji Ichino, Kanade Tatsumi, Keishi Osakabe, Bunta Watanabe, Koichiro Shimomura, Kazufumi Yazaki. Peroxisomal 4-coumaroyl-CoA ligases participate in shikonin production in Lithospermum erythrorhizon. Plant Physiol. 2024
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Kotaro Mori, Yoshiaki Nakagawa, Bunta Watanabe, Hiroshi Miyata, Tsuyoshi Morita, Ken'ichiro Hayashi. Novel ability of diflubenzuron as an inhibitor of mitochondrial function. Insect Biochem. Molecular Biol. 2024. 167. 104088
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Bunta Nishikawa, Kotaro Mori, Seisuke Takimoto, Bunta Watanabe, Midori Matsuo, Takeshi Nakano, Yoshiaki Nakagawa, Hisashi Miyagawa. Quantitative evaluation of the biological activity of various brassinosteroids using spiral root induction in rice seeds. J. Pestic. Sci. 2023. 48. 4. 218-224
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Hiromu Kameoka, Shota Shimazaki, Kiyoshi Mashiguchi, Bunta Watanabe, Aino Komatsu, Akiyoshi Yoda, Yohei Mizuno, Kyoichi Kodama, Masanori Okamoto, Takahito Nomura, et al. DIENELACTONE HYDROLASE LIKE PROTEIN1 negatively regulates the KAI2-ligand pathway in Marchantia polymorpha. Current Biol. 2023. 33. 16. 3505-3513
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MISC (163)：
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宮崎麻紗美, 藤山敬介, 日野智也, 佐藤裕介, LEE Hyoung Jae, 秋山遼太, 加藤純平, 水谷正治, 庄司光男, 重田育照, et al. Structural biology of plant steroids biosynthesis and metabolic detoxification. 日本薬学会年会要旨集(Web). 2022. 142nd
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秋山遼太, 中安大, 中安大, 渡辺文太, 加藤純平, LEE Hyoung Jae, 飯島陽子, 梅基直行, 村中俊哉, 齊藤和季, et al. 2-oxoglutarate dependent dioxygenases involved in biosynthesis of steroidal glycoalkaloids. 日本植物生理学会年会(Web). 2022. 63rd
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押切春佳, LI Hao, 渡辺文太, 山本浩文, 矢崎一史, 高梨功次郎, 高梨功次郎. Functional differentiation of acyltransferases involved in the production of shikonin/alkannin derivatives in Lithospermum erythrorhizon. 日本農芸化学会大会講演要旨集(Web). 2021. 2021
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吉村和貴, 渡辺文太, 中川友喜美, 矢崎一史, 高梨功次郎. Substrate specificity of geranylhydroquinone hydroxylase in shikonin/alkannin biosynthetic pathway. 日本農芸化学会大会講演要旨集(Web). 2021. 2021
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押切春佳, LI Hao, 渡辺文太, 矢崎一史, 高梨功次郎, 高梨功次郎. Functional differentiation of shikonin/alkannin acyltransferases in Lithospermum erythrorhizon. 日本植物生理学会年会(Web). 2020. 61st
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Patents (16)：
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GGT阻害作用を有する化合物及びGGTファミリー酵素阻害剤
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ナールスゲンの光学分割方法
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グルタチオン産生促進剤
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角化細胞遊走・増殖促進剤を含む、創傷治癒剤および褥瘡(床ずれ)治療薬
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ピラゾ-ル-4-カルボキサミド誘導体、それらの製造方法及びそれらを有効成分とする殺菌剤
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Books (2)：
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虚血性急性腎障害に対する新規選択的γ-glutamyl transpeptidase阻害薬GGsTopTMの改善効果について
腎とフリーラジカル, 11, 146-149 2013 ISBN:9784885632167
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A Chemical Approach for Elucidating the Molecular Interaction of Host-Specific AK-Toxin with Japanese Pear.
Advances in Microbial Toxin Research and its Biotechnological Exploitation (Kluwer Academic/Plenum Publishers), pp1-21 2002 ISBN:9781475744392
Lectures and oral presentations (8)：
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グルタチオン代謝酵素とアンチエイジング
(第52回機能性食品用ペプチド研究会 2018)
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グルタチオンと活性酸素種:酵素の阻害剤研究からアンチエイジング化粧品の実用化へ
(第22回化学研究所公開講演会 2015)
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機能性タンパク質を標的とした阻害剤の合成と応用
(第32回藤田カンファレンス 2015)
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昆虫および植物ステロイドホルモンの構造活性相関
(日本農薬学会第40回大会 2015)
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GGT阻害剤の化粧品原体としての開発研究
(第15回京都大学宇治キャンパス産学交流会 2015)
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Education (3)：
- 2000 - 2004 Kyoto University Graduate School of Agriculture Division of Applied Life Sciences
- 1998 - 2000 Kyoto University Graduate School of Agriculture Division of Applied Life Sciences
- 1994 - 1998 Kyoto University Faculty of Agriculture
Professional career (1)：
- Doctor of Agriculture (Kyoto University)
Work history (5)：
- 2022/04 - 現在 The Jikei University School of Medicine Faculty of Medicine School of Medicine Associate Professor
- 2009/03 - 2022/03 Kyoto University Institute for Chemical Research Assistant Professor
- 2005/11 - 2009/02 Sagami Chemical Research Institute
- 2005/01 - 2005/11 Kyoto University Graduate School of Agriculture
- 2004/04 - 2005/01 Kyoto University Institute for Chemical Research
Awards (2)：
- 2015/03 - Pesticide Science Society of Japan Society Award (on high prospectiveness) Structure-activity relationship studies of insect and plant steroid hormones
- 2007 - Japan Society for Bioscience, Biotechnology, and Agrochemistry Award for Excellence to Authors Publishing in Bioscience, Biotechnology, and Biochemistry in 2006 CYP7242 and CYP90B3 function in the early C-22 hydroxylation steps of brassinosteroid biosynthetic pathway in tomato.
Association Membership(s) (4)：
Pesticide Science Society of Japan
, Japan Society for Bioscience, Biotechnology and Agrochemistry
, The Japanese Conference on the Biochemistry of Lipids
, The Japanese Society for Extremophiles
