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J-GLOBAL ID：200901043833031138   Update date: Aug. 29, 2024

Watashi Koichi

ワタシ コウイチ | Watashi Koichi
Affiliation and department：
National Institute of Infectious Diseases Research Center for Drug and Vaccine Development

About National Institute of Infectious Diseases Research Center for Drug and Vaccine Development


Job title： Director, Division of Drug Development
Other affiliations (2)：
Research field  (3)： Virology ,  Pharmaceuticals - health and biochemistry ,  Molecular biology
Research keywords  (10)： HBV ,  HCV ,  hepatitis D virus ,  coronavirus ,  poxvirus ,  Chemical Biology ,  Anti-viral ,  virus dynamics ,  modality ,  anti-infectives
Research theme for competitive and other funds  (9)：
  • 2021 - 2024 Structure and functional analysis of the SARS-CoV-2 Nucleocapsid Protein
  • 2020 - 2023 Molecular mechanism, dynamics, and interaction with environment in the hepatitis B virus entry system
  • 2017 - 2020 Mechanistic analysis of hepatitis B virus entry and the host factors using new cell culture systems
  • 2016 - 2019 Systems Virology for understanding viral pathogenesis
  • 2014 - 2018 Analysis of regulation mechanisms of hepatitis B virus life cycle by kinases and post-translational modifications
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Papers (219)：
  • Masako Yamasaki, Wakana Saso, Takuya Yamamoto, Masayoshi Sato, Hiroko Takagi, Tetsuya Hasegawa, Yuji Kozakura, Hiroyuki Yokoi, Hirofumi Ohashi, Kana Tsuchimoto, et al. Anti-SARS-CoV-2 gapmer antisense oligonucleotides targeting the main protease region of viral RNA. Antiviral research. 2024. 105992-105992
  • Nozomi Mosu, Mitsuki Yasukochi, Shogo Nakajima, Kou Nakamura, Masaya Ogata, Keita Iguchi, Kazuki Kanno, Tomohiro Ishikawa, Kazutoshi Sugita, Hironobu Murakami, et al. Isolation, structural determination, and antiviral activities of a novel alanine-conjugated polyketide from Talaromyces sp. The Journal of antibiotics. 2024
  • Azumi Tamura, Aa Haeruman Azam, Tomohiro Nakamura, Kenichi Lee, Sunao Iyoda, Kohei Kondo, Shinjiro Ojima, Kotaro Chihara, Wakana Yamashita, Longzhu Cui, et al. Synthetic phage-based approach for sensitive and specific detection of Escherichia coli O157. Communications Biology. 2024. 7. 1
  • Hbv, Lena Allweiss, Chari Cohen, Joao Dias, Valeria Fumagalli, Haitao Guo, James M Harris, Jianming Hu, Matteo Iannacone, Masanori Isogawa, et al. Highlights from the 2023 International Meeting on the Molecular Biology of Hepatitis B virus. The Journal of general virology. 2024. 105. 5
  • Shinjiro Ojima, Aa Haeruman Azam, Kohei Kondo, Wenhan Nie, Sai Wang, Kotaro Chihara, Azumi Tamura, Wakana Yamashita, Tomohiro Nakamura, Yo Sugawara, et al. Systematic Discovery of Phage Genes that Inactivate Bacterial Immune Systems. 2024
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MISC (67)：
  • 山下 和可奈, 小島 新二郎, アザム・アア・ハエルマン, 近藤 恒平, 中村 暢宏, 田村 あずみ, 渡士 幸一, 崔 龍洙, 常田 聡, 氣駕 恒太朗. ファージ由来溶菌酵素の殺菌力と作用域の調査. 日本細菌学雑誌. 2023. 78. 1. 148-148
  • 青柳東代, 飯島尋子, 若江亨祥, 渡士幸一, 鈴木亮介, 政木隆博, 政木隆博, 杉山真也, 坪田昭人, 島田紀朋, et al. C型肝炎ウイルス除去後の病態,発癌のメカニズム. 肝細胞研究会プログラム・抄録集. 2023. 30th
  • 深野顕人, 深野顕人, 若江亨祥, 直亨則, 直亨則, 斎藤益満, 斎藤益満, 豊嶋孝恵, 坪田昭人, 相崎英樹, et al. Development of prognostic markers for hepatocellular carcinoma using a novel detection method for hepatitis B virus DNA integration. 日本ウイルス学会学術集会プログラム・予稿集(Web). 2023. 70th
  • 青柳東代, 飯島尋子, 松田麻未, 若江亨祥, 渡士幸一, 鈴木亮介, 政木隆博, 杉山真也, 坪田昭人, 島田紀朋, et al. Correlation between hepatocellular organelles, gene expression abnormalities and carcinogenesis following elimination of hepatitis C virus. 日本ウイルス学会学術集会プログラム・予稿集(Web). 2023. 70th
  • 相崎英樹, 青柳東代, 飯島尋子, 松田麻未, 若江亨祥, 渡士幸一, 鈴木亮介, 政木隆博, 政木隆博, 杉山真也, et al. C型肝炎ウイルス除去後の病態,発癌のメカニズム. 臨床化学(Web). 2023. 52
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Professional career (2)：
  • Ph.D. (Kyoto University)
  • Master (Pharmaceutical Sciences) (Kyoto University)
Work history (8)：
  • 2022/04 - 現在 (併任)早稲田大学大学院 先進理工学研究科 客員教授
  • 2021/04 - 現在 National Institute of Infectious Diseases Research Center for Drug and Vaccine Development Director, Division of Drug Development
  • 2019/04 - 現在 Tokyo University of Science Graduate School of Science and Technology Department of Biological Sciences (Dual Appointment) Visiting Professor
  • 2009/12 - 2021/03 National Institute of Infectious Diseases Department of Virology II Senior Researcher
  • 2011/04 - 2019/03 Tokyo University of Science Graduate School of Science and Technology Department of Biological Sciences (Dual Appointment) Visiting Associate Professor
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Awards (7)：
  • 2023 - 国際B型肝炎ウイルス学会(2023年 神戸) 学会長
  • 2017 - 日本肝臓学会 MSDアワード
  • 2016 - 大正富山Award
  • 2013 - Liver Forum in Kyoto 研究奨励
  • 2012 - 日本肝臓学会STC Young Investigator Award
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Association Membership(s) (5)：
THE PHARMACEUTICAL SOCIETY OF JAPAN ,  Japanese Association of Antiviral Therapy ,  THE JAPAN SOCIETY OF HEPATOLOGY ,  日本分子生物学会 ,  日本ウイルス学会
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