Rchr
J-GLOBAL ID：200901043846300847
Update date: Sep. 25, 2024
TAKESHITA TOSHIKAZU
タケシタ トシカズ | TAKESHITA TOSHIKAZU
Affiliation and department：
Job title：
Professor
Homepage URL (1)：
http://www.shinshu-u.ac.jp/faculty/medicine/chair/immunobiology/
Research field (2)：
Immunology
, Virology
Research theme for competitive and other funds (26)：
- 2021 - 2024 胆管癌の浸潤転移能獲得におけるS100A10の機能解明と治療戦略への展開
- 2021 - 2024 高選択性JAK3阻害薬創生に向けたJAK3活性化の時空間的制御機構の解明
- 2020 - 2023 Single nucleotide variants that could serve as the predictive indicator of intravenous immunoglobulin therapy-unresponsive Kawasaki disease.
- 2018 - 2021 Functional role of S100 proteins in maintenance of the malignant phenotype in cancer stem cells of cholangiocarcinoma
- 2016 - 2018 川崎病とサイトカイン受容体の変異および遺伝子多型との関連
- 2013 - 2016 Ubiquitin-independent endosomal sorting of cytokine receptors
- 2013 - 2016 Endosomal sorting signal of cytokine receptors and its single nucleotide polymorphism in allergy disease
- 2009 - 2011 Identification of ubiquitin-dependent endosomal sorting signal in cytokine receptors
- 2002 - 2003 Control of immunological tolerance and its breakdown by cytokine
- 2000 - 2001 Cytokine receptor γc chain/Jak3 mediated signal transduction and analysis of immunodeficiecy by dysfunction of the γc chain/Jak3
- 2000 - 2000 Smads活性化に関わるチロシンリン酸化分子Hgsの細胞増殖がん化における役割
- 1999 - 1999 Smads活性化に関わるチロシンリン酸化分子Hrsの細胞増殖がん化における役割
- 1998 - 1999 Cytokine receptor γc chain mediated signal transduction and analysis of immunodeficiency by dysfunction of the γc chain
- 1998 - 1998 サイトカイン受容体を介する新たな増殖シグナル伝達経路“Jak-STAM"
- 1996 - 1996 サイトカイン共通受容体(γc鎖)を介した細胞内情報伝達機構
- 1996 - 1996 新規IL-2依存性チロシンリン酸化蛋白分子(pp70)の機能的役割
- 1995 - 1996 Investigation on SIL2 receptor, beta gamma in immune nervous system diseases
- 1995 - 1995 サイトカイン共通受容体(γc鎖)を介した細胞内情報伝達機構
- 1995 - 1995 新規IL-2依存性チロシンリン酸化蛋白分子(pp70)の機能的役割
- 1994 - 1994 インターロイキン2受容体γ鎖の発現と機能
- 1994 - 1994 Tリンパ球特異的チロシンキナーゼItkの細胞増殖分化における役割
- 1993 - 1994 IL-2受容体γ鎖の機能ならびに発現制御に関する研究
- 1992 - 1992 IL-2受容体新らたなサブユニットr鎖の機能解析
- 1991 - 1992 Expression of interleukin 2 receptor subunits and mechanism of T cell growth
- 1989 - 1990 The Role of IL-2 Receptor Alpha and Beta Chain in Growth and Differentiation of Lymphocytes
- サイトカインのシグナル伝達機構
Show all
Papers (22)：
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Kobayashi, Maki, Kojima, Katsuhiko, Murayama, Kazutaka, Amano, Yuji, Koyama, Takashi, Ogama, Naoko, Takeshita, Toshikazu, Fukuhara, Tatsuro, Tanaka, Nobuyuki. MK-6, a novel not-alpha IL-2, elicits a potent antitumor activity by improving the effector to regulatory T cell balance. CANCER SCIENCE. 2021. 112. 11. 4478-4489
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Yuichiro Ide, Ryu Yanagisawa, Jun Kobayashi, Kazutoshi Komori, Kazuyuki Matsuda, Yuji Amano, Yozo Nakazawa, Toshikazu Takeshita, Kazuo Sakashita, Minoru Tozuka. Relationship between allergic sensitisation-associated single-nucleotide polymorphisms and allergic transfusion reactions and febrile non-haemolytic transfusion reactions in paediatric cases. Blood Transfusion. 2021. 20. 2. 94-102
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Amano Y., Akazawa K., Yasuda J., Yoshino K., Kojima K., Kobayashi K., Matsuzaki S., Nakasaki M.,Kawai Y., Minegishi N., Ishida N., Motoki N.,Hachiya A.,Nakazawa Y.,Yamamoto M., Koike K. Takeshita T. A low-frequency IL-4R locus variant in Japanese patients with intravenous immunoglobulin therapy-unresponsive Kawasaki disease. Pediatr Rheumatol. 2019. 17(1):34
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Nakada, Tsutomu, Kashihara, Toshihide, Komatsu, Masatoshi, Kojima, Katsuhiko, Takeshita, Toshikazu, Yamada, Mitsuhiko. Physical interaction of junctophilin and the Ca(V)1.1 C terminus is crucial for skeletal muscle contraction. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2018. 115. 17. 4507-4512
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Kashihara, Toshihide, Nakada, Tsutomu, Kojima, Katsuhiko, Takeshita, Toshikazu, Yamada, Mitsuhiko. Angiotensin II activates Ca(V)1.2 Ca2+ channels through beta-arrestin2 and casein kinase 2 in mouse immature cardiomyocytes. JOURNAL OF PHYSIOLOGY-LONDON. 2017. 595. 13. 4207-4225
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