Research keywords (7):
Glycoproteome
, Glycoproteomics
, Mass Spectrometry
, Posttranslational modification
, Glycosylation
, Proteomics
, Proteome
Research theme for competitive and other funds (9):
2015 - 2018 Elucidation of biological function of glycan by integrated omics analysis based on glycoproteome.
2015 - 2017 Development of a method to analyze glycosylation site-specific glycome at proteome-scale for study on significance of glycan heterogeneity
2012 - 2015 Elucidation of regulation/control mechanisms in glycan-mediated functions of cell-surface biomolecules.
2012 - 2015 N-glycosylated glycoproteome analysis of glycosyltransferase-modified mice for comprehensive understanding of glycan functions
2006 - 2008 Functional proteomics studies on the mechanism of differentiation of mouse embryonic stem cells
2006 - 2007 Development of a method for high-throughput, large-scale quantitative analysis of glycosylated proteins.
2004 - 2005 Development of a method for large-scale analysis of glycosylated proteins in the worm, C.elegans.
1997 - 1998 プロテアーゼインヒビターの阻害活性調節機構
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Papers (90):
Chiaki Nagai-Okatani, Daisuke Tominaga, Azusa Tomioka, Hiroaki Sakaue, Norio Goda, Shigeru Ko, Atsushi Kuno, Hiroyuki Kaji. GRable version 1.0: A software tool for site-specific glycoform analysis with improved MS1-based glycopeptide detection with parallel clustering and confidence evaluation with MS2 information. Molecular & cellular proteomics : MCP. 2024. 100833-100833
Kiyoko F Aoki-Kinoshita, Hiromune Ando, Kiyohiko Angata, Morihisa Fujita, Jun-Ichi Furukawa, Hiroyuki Kaji, Koichi Kato, Ken Kitajima, Yasuhiko Kizuka, Yusuke Matsui, et al. The Human Glycome Atlas Project for cataloging all glycan-related omics data in human. Glycobiology. 2024
Takahiro Hiono, Hiroaki Sakaue, Azusa Tomioka, Hiroyuki Kaji, Michihito Sasaki, Yasuko Orba, Hirofumi Sawa, Atsushi Kuno. Combinatorial Approach with Mass Spectrometry and Lectin Microarray Dissected Site-Specific Glycostem and Glycoleaf Features of the Virion-Derived Spike Protein of Ancestral and γ Variant SARS-CoV-2 Strains. Journal of proteome research. 2024. 23. 4. 1408-1419
Chiaki Nagai-Okatani*#, Daisuke Tominaga*, Azusa Tomioka*, Hiroaki Sakaue, Norio Goda, Shigeru Ko, Atsushi Kuno, Hiroyuki Kaji#. GRable version 1.0: A software tool for site-specific glycoform analysis using the improved Glyco-RIDGE method with parallel clustering and MS2 information. bioRxiv. 2023
岡谷千晶, 富永大介, 富岡あづさ, 坂上弘明, 合田徳夫, 洪繁, 久野敦, 梶裕之, 梶裕之. GRable Version 1.0: A software tool for an MS1-based site-specific glycoform analysis by a Glyco-RIDGE method. 日本プロテオーム学会大会プログラム・抄録集. 2023. 2023 (CD-ROM)