Hashimoto Wataru

2019 - 2022 Construction of the brown macroalgae-based biorefinery system for the high production of terpenoid and lipids

2019 - 2021 Development of bases on next-generation fermentation technology using atmospheric nitrogen and construction of sustainable society

2018 - 2021 Elucidation of dynamics and colonization mechanisms of microbiota targeting animal extracellular matrices and their application development

2016 - 2019 Construction of transport systems by analysis and modification of molecular mechanism of macromolecule-importing ABC transporter

2016 - 2018 Novel and innovative mechanism of ATP biosynthesis based on the plasmolysis as a proton-driven force in alkalophilic bacteria

2015 - 2018 Structural life science of pathogenic bacterial systems targeting animal host extracellular matrix for colonization and infection

2014 - 2017 Three-dimensional structure and functionof ABC transporter responsible for macromolecule transport in bacteria

2014 - 2016 A novel metal-import system in the pit-forming bacterium and its application for recovery of radioactive compounds and rare metals

2011 - 2014 Structure and function of complex of substrate-binding protein and macromolecule-specific ABC transpoter

2011 - 2013 Metabolic mechanism of host extracellular matrices, glycosaminoglycans, in streptococci

2008 - 2010 Structure/function relationship and cell surface localization mechanism of bacterial flagelin

2008 - 2010 Structure and function of streptococcal system for heparin degradation/import and its involvement in infectious diseases

2006 - 2007 タンパク質の「揺らぎ」と機能発現における水分子の役割

2006 - 2007 Molecular and structural biostudies on streptococcalinyasion/infection mechanisms to host cells through degradation of extracellular matrices glyoceaminoglycans

2006 - 2007 体腔器官の分子移植による細菌の構造と機能の大規模改変とその応用

2005 - 2007 Molecular basis for cell surface architecture and evolution of bacterial flagellin by structure and unction analysis of the protein

2003 - 2005 高分子物質の結合と分解に関わるタンパク質・酵素の機能を規定する動的高次構造の解析

2004 - 2004 「小胞状構造体」の形成に関わる細菌細胞膜のダイナミクス

2002 - 2004 Biochemical significance of the non-common amino acid sequences specifying the common functions of enzymes, polysaccharide lyases

2003 - 2003 細菌の細胞膜流動による「小胞状構造体」の形成に関わる遺伝子ネットワークの解明

2001 - 2002 緑膿菌エコーシステムにおけるバイオフィルムの酵素・遺伝学的特性解析とその応用

2001 - 2001 難治性細菌感染症における細菌の増殖、潜伏及び感染持続機構の解析と新規治療法の確立

2000 - 2001 DNA分子の戦略的生存システムの解析とその応用

1999 - 2001 Structure/function analysis of abundance and transmission mechanism of genetic information invlolved in the biosynthesis of multi-catalytic site enzyme

1999 - 2000 X線結晶構造解析による多糖リアーゼの構造・機能相関と構造的一般則

1998 - 2000 Function and safety of bacterial alginate lyase for the therapy of biofilm-dependent infection of Pseudomonas aeruginosa

1999 - 1999 細菌細胞表層における体腔形成機構と体腔の高分子輸送機構

1998 - 1998 細菌細胞表層への体腔提示と体腔への高分子ターゲッティング機構

1997 - 1998 細菌多糖リアーゼの多面的機能・構造相関解析と医薬・食品領域への応用

1996 - 1996 多糖の合成と分解に関わるスヒンゴモナス属細菌表層の穴構造と新規高分子取り込み機構