- 2024 - 2027 幹細胞レザバー破綻による顎骨壊死進展メカニズムの解明と幹細胞輸注による治療法開発
- 2022 - 2025 Development of Tetra-PEG gel molded regenerated cartilage to achieve scaffold-Free
- 2022 - 2025 ARONJ治療に用いるMSC由来エクソソームの責任因子および作用機序の同定
- 2022 - 2025 エクソソームを介した軟骨細胞・マクロファージ間相互作用の解明
- 2021 - 2024 口蓋裂患者における口蓋裂幅と言語成績の検討~音響特性評価による新規診断値の設定~
- 2021 - 2024 Wntシグナルによる骨モデリング・リモデリング制御機構の時空間的解析
- 2021 - 2024 エピジェネティック調節制御による口腔癌の時空間的発症機構の解明と臨床検査法の確立
- 2021 - 2024 動的ゴーストイメージング技術を用いた高骨形成細胞集団の分取と機能的再生骨の実現
- 2019 - 2023 マクロファージ・ポラリゼーションに基づくARONJ新規スクリーニング法の開発
- 2018 - 2023 組織再生を誘導する生体シグナルにおけるマクロファージ・エクソソームの役割
- 2019 - 2022 Elucidation of ECM-cell regulatory mechanisms in regenerative tissues and practical application of allografts
- 2019 - 2022 Study on treatment of jaw bone necrosis using a subpopulation of MSCs that activate immunity
- 2019 - 2021 Establishment of a proliferation culture method for hematopoietic stem cells utilizing a novel subpopulation of mesenchymal stem cells
- 2018 - 2021 Elucidation of stem cell signal using genome structure as an index and application to bone regenerative medicine
- 2018 - 2021 Analysis of coupling by shRNA screening using a bone remodeling resconstitution system
- 2017 - 2020 Identification of regulatory factors contributing to migration or recruitment of osteoblast progenitors by genome-wide approach and the application for bone repair
- 2017 - 2020 Elucidation of regenerative tissue maturation signal by focused proteomic analysis and its application to regenerative medicine
- 2017 - 2019 Validation of scarless healing and fusion of the fetal mouse cleft lip like defect by administrating the Bandage-type engineered tissue achieving fetal treatment for the patient with a cleft lip.
- 2016 - 2019 Elucidation of cellular immune mechanism for allogeneic tissue-engineered cartilage and the effectiveness of super allograft
- 2016 - 2019 Examination of osteonecrosis of the jaw treatment method by autologous iPS cell origin mesenchymal stem cell
- 2014 - 2019 Development of a novel strategy for bone regeneration with small molecule-mediated osteo-reprogramming and understanding of genomic mechanisms underlying the process
- 2015 - 2018 Acceleration of differentiation and maturation of iPS cell via coculture with matuer cells
- 2015 - 2018 Analysis of damage-associated molecular patterns (DAMPs) in autologous tissue-engineered cartilage and its application to regenerative medicine
- 2015 - 2018 Large scale amplification of tissue-repairing macrophages by regulation of subset differentiation and their application for tissue regeneration.
- 2015 - 2017 Elucidation of fibrous dysplasia pathogenesis using disease-specific iPS cells and application to drug discovery
- 2014 - 2017 Strategic research on development of bone regenerative therapy with in vivo delivery of nucleic acids
- 2014 - 2017 Development of Bone Regeneration Method Utilizing Hematopoietic-Mesenchymal Interaction and Clinical Application to Orthodontics
- 2014 - 2017 Development of novel cartilage regeneration method utilizing regenerative precursor cells and in vivo maturation promoting factor
- 2014 - 2017 The development of tissue regeneration method using molecular biological chimeric induction and inhibitory cytokine
- 2013 - 2016 The manufacture of the regeneration bone by the minimum differentiation induction of iPS cells and application to a pig defect of jaw bone model
- 2013 - 2016 Patch tracheoplasty in body tissue engineering using collagenous connective tissue membranes(biosheets)
- 2014 - 2015 低分子化合物を用いた骨ダイレクトリプログラミングによる新規骨再生技術の開発
- 2013 - 2015 3次元顔面軟骨オルガノイド開発を目的とした移植母床の「場の原理」解明
- 2013 - 2015 development of functional regenerative bone as a stem cell reserver
- 2012 - 2015 The establishment of isolation and culture system by adhesion for periosteum stem cells: application to mandibular reconstruction
- 2012 - 2015 Investigation on phenotypes of macrophages in transplantation of engineered tissues and its application to regenerative medicine
- 2012 - 2015 Identification of stem-ness signal in mesencymal stem cells by mesenchymal-hematopoietic interaction and application to regenerative medicine
- 2013 - 2014 骨芽細胞シートと人工類骨を用いた骨基質石灰化の解明と骨形成促進技術への展開
- 2010 - 2014 Cartilage repair using a scaffold free tissue engineered construct derived from multipotent stem cell
- 2011 - 2013 Minimal reprogramming of cultured MSC based on DNA methylation analysis
- 2011 - 2013 Establishment of in situ bone regenerative technology to induce mature cortical bone formation containing osteons
- 2011 - 2013 Tracheoplasty by combined growth factor and injectable cell therapy
- 2009 - 2011 コンポジット・スカフォールド導入による新規再生軟骨の開発
- 2009 - 2011 The investication of factors related to odontoblast diffenetiation and morphology preservation, and analysis of expression
- 2009 - 2011 Development on scaffold-free 3D regenerative cartilage as surgical implants
- 2009 - 2010 MPCポリマーを用いた間葉系幹細胞濃縮技術による再生組織の高性能化
- 2008 - 2010 Analysis of re-differentiation mechanism in perichondrium-like tissues around tissue-engineered cartilage using p53 knockout mice
- 2008 - 2010 Three dimensionally layered spheroid array for tissue organization
- 2007 - 2008 Analysis on tissue reactions to tissue-engineered cartilage in transgenic mice and optimization of scaffolds
- 2006 - 2008 Development of tracheoplasty using tissue engineered tracheal cartilage
- 2006 - 2008 Molecular mechanisms of cartilage degeneration by mechanical stress
- 2006 - 2007 3次元増殖培養装置と非侵襲評価装置の機能を有する軟骨再生のための新規足場素材の開発
- 2006 - 2007 Bone regeneration for secondary bone graft and orthodontic evaluation
- 2006 - 2007 Research to enhance potentials of mesenchymal calls by introducing Nanog gene and its application to regenerative medicine of bone and cartilage
- 2004 - 2006 Research and Development for Fabrication of 3D-structured Tissue-engineered Cartilage through Nino-molecular Technologies
- 2003 - 2006 Research on Pathophysiology and Novel Treatment of Osteoarthritis through Molecular Biological Approach
- 2004 - 2005 コンピューター支援デザインによる積層造型法を応用した3次元再生骨構築法の確立
- 2004 - 2005 再生骨および歯と受容者(recipient)組織間の特異的相互作用の解析
- 2004 - 2005 Teeth eruption and movement in tissue-engineered bone
- 2004 - 2005 Novel tissue regeneration using polymer nano-micelle gene delivery system
- 2003 - 2005 Analysis of expression pattern of fibrocartilage with a view to promoting regenerative medicine of temporomandibular joint
- 2003 - 2005 Basic study on cartilage, bone and tendon tissue engineering by using physical factors
- 2003 - 2005 Elucidation of molecular mechanism involved in mechanical stress signaling in bone - functional analysis, contribution to pathology, and cloning of related molecule of a novel gene Znt5 -
- 2003 - 2005 Inhibition of aseptic loosening of artificial joints by graft polymerizaiton of a novel biocompatible polymer MPC
- 2002 - 2005 Contribution of new prostaglandin E_2 synthase to bone resorptive pathology and clinical application of PGES inhibitor
- 2002 - 2004 Study of the pathophysiology of congenital pseudarthrosis of the tibia.
- 2002 - 2004 Study of the function of cystatin 10, a novel chondrocyte-specific gene.
- 2000 - 2004 老化関連骨軟骨疾患におけるklotho遺伝子の関与
- 2002 - 2003 MRIラットにおける軟骨異常病態の解明とその原因遺伝子の同定
- 2002 - 2003 慢性関節リウマチにおける腱断裂機序の解明と治療法の確立
- 2002 - 2003 Development of PIG micelle vector system for gene delivery
- 2002 - 軟骨再生医療
- 2002 - Cartilage tissue engineering
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