Rchr

J-GLOBAL ID：200901045379935291 Update date: Apr. 02, 2024

Shirasaka Yoshiyuki

シラサカヨシユキ | Shirasaka Yoshiyuki

Affiliation and department：
Job title：准教授
Homepage URL (2)： http://www.p.kanazawa-u.ac.jp/lab/doutai.html , http://www.p.kanazawa-u.ac.jp/e/lab/doutai.html

Research field (3)： Clinical pharmacy , Clinical pharmacy , Clinical pharmacy

Research keywords (8)： Pharmacokinetics , Biopharmaceutics , Drug Absorption , Drug Interaction , Gastrointestinal Toxicity , Drug Transport , Drug Metabolism , Bioavailability

Research theme for competitive and other funds (23)：

2024 - 2028 Establishment of predictive approach of oral drug absorption based on gastrointestinal imaging analysis using quantum dot and tissue clearing technologies
2023 - 2027 Quantitative analysis for predicting oral absorption of peptide drugs using transparent intestinal imaging technology with quantum dots
2023 - 2025 Regulation of inflammatory response by uric acid via uric acid binding protein CD38
2020 - 2024 Quantitative Prediction of Oral Drug Absorption by Kinetically Analyzing Gastrointestinal Water Dynamics
2021 - 2023 Quantitatively Analysis of Gastrointestinal Fluid Dynamics to Predict Food/Beverage-Drug Interactions

2021 - 2023 Establishment of Quantitative Methodology to Predict Drug-Induced Gastrointestinal Toxicity Based on Kinetic Analysis of Serotonin-Regulated Body Fluid

2020 - 2021 Quantitative Analysis of Body Fluid Regulated by Serotonin Transporter and Its Application to Prediction of Drug-Induced Gastrointestinal Toxicity

2020 - 2021 Development of anti-COVID-19 therapy to suppress severe pneumonia by combination using adenovirus vector with ultra-multi guide RNA expression system and protease inhibitors

2017 - 2021 Kinetic Analysis of Gastrointestinal Water Absorption to Quantitatively Predict Drug-Beverage and -Food Interactions

2016 - 2019 Evaluation of Oral Drug Absorption by Developing In Vitro Culture System for Intestinal Villus Cells

2018 - 2019 The 3rd Workshop for Japan-Korea Young Scientists on Pharmaceutics

2015 - 2016 Quantitative Analysis of the Effect of Controlled-release on Intestinal Absorption of P-gp and CYP3A Substrate Drugs

2015 - 2016 Quantitative Analysis of Site-Dependent Intestinal Absorption of Drugs

2014 - 2014 Kinetic Analysis of Transporters- and Metabolic Enzymes-Mediated Drug Absorption

2012 - 2014 Quantitative Evaluation of the Effect of Transporters and Metabolic Enzymes on Oral Drug Absorption

2011 - 2013 Regional Difference in the Effect of Influx/Efflux Transporters and Metabolic Enzymes on Intestinal Drug Absorption

2009 - 2011 Clarification and evaluation of regulation mechanism of uric acid

2009 - 2010 Quantitative Evaluation of the Effect of Influx/Efflux Transporters on Oral Drug Absorption

2009 - 2010 細胞内オルガネラ膜トランスポーター活性の定量的可視化による薬物の細胞毒性評価

2009 - 2010 Evaluation of molecular mechanisms of tumor-specific protoporphyr in accumulation induced by 5-aminolevulinic acid

2008 - 2009 吸収/排泄型トランスポーターの優位性に基づいた消化管吸収性評価システムの構築

2007 - 2008 Species difference in hepatic disposition of organic anions

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Papers (80)：

Yoshiyuki Shirasaka, Atsushi Kambayashi. Food effects on oral drug absorption: Recent advances in understanding mechanisms and quantitative prediction. Drug Metabolism and Pharmacokinetics. 2024. 54. 100533-100533
Miyuki Takemura, Katsuhisa Inoue, Ikumi Tamai, Yoshiyuki Shirasaka. Magnitude of Fruit Juice-Drug Interactions Due to Osmolality-Dependent Fluid Secretion: Differences among Apple, Orange, and Grapefruit Juices. Biological and Pharmaceutical Bulletin. 2024. 47. 1. 72-78
Yugo Yasugi, Yoshiyuki Shirasaka, Ikumi Tamai. Quantitative analysis of the impact of membrane permeability on intestinal first-pass metabolism of CYP3A substrates. Biopharmaceutics & Drug Disposition. 2023
Koki Sugiyama, Hiroe Shimano, Masaki Takahashi, Yuta Shimura, Asuka Shimura, Takahito Furuya, Ryuto Tomabechi, Yoshiyuki Shirasaka, Kei Higuchi, Hisanao Kishimoto, et al. The Use of Carboxyfluorescein Reveals the Transport Function of MCT6/SLC16A5 Associated with CD147 as a Chloride-Sensitive Organic Anion Transporter in Mammalian Cells. Journal of Pharmaceutical Sciences. 2023
Keisuke Kiyomiya, Ryuto Tomabechi, Naoki Saito, Kenta Watai, Tappei Takada, Yoshiyuki Shirasaka, Hisanao Kishimoto, Kei Higuchi, Katsuhisa Inoue. Macrolide and Ketolide Antibiotics Inhibit the Cytotoxic Effect of Trastuzumab Emtansine in HER2-Positive Breast Cancer Cells: Implication of a Potential Drug-ADC Interaction in Cancer Chemotherapy. Molecular Pharmaceutics. 2023

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MISC (34)：

Yoshiyuki Shirasaka, Nora Lee, Haichuan Duan, Weibin Zha, Joanne Wang. MULTIPLE TRANSPORT MECHANISMS INVOLVED IN THE INTESTINAL ABSORPTION AND DISPOSITION OF ANTIDIABETIC METFORMIN. DRUG METABOLISM REVIEWS. 2015. 47. 242-243
Yoshiyuki Shirasaka, Amarjit S. Chaudhry, Timothy Wong, Justina C. Calamia, Nina Isoherranen, Allan E. Rettie, Erin G. Schuetz, Kenneth E. Thummel. INTERINDIVIDUAL VARIABILITY OF CYP2C19-CATALYZED DRUG METABOLISM DUE TO DIFFERENCES IN THE DIPLOTYPES. DRUG METABOLISM REVIEWS. 2014. 45. 29-30
Yoshiyuki Shirasaka, Chi-Chi Peng, Shu-Ying Chang, Mary F. Grubb, Stephen R. Johnson, A. David Rodrigues, Kenneth E. Thummel, Nina Isoherranen. IMPACT OF CYP3A5 EXPRESSION ON THE INHIBITION OF CYP3A-CATALYZED DRUG METABOLISM: CONSIDERATIONS FOR MODELING CYP3A-MEDIATED DRUG-DRUG INTERACTIONS. DRUG METABOLISM REVIEWS. 2012. 44. 83-84
Arakawa Hiroshi, Nakanishi Takeo, Shirasaka Yoshiyuki, Tamai Ikumi. Upregulation of organic anion-transporting polypeptide (OATP) 1A2 by depletion of androgens; a possible molecular mechanism of castration resistance in prostate cancer. DRUG METABOLISM REVIEWS. 2011. 43. 23
Shichiri Megumi, Shirasaka Yoshiyuki, Mori Takanori, Nakanishi Takeo, Tamai Ikumi. Differential interaction of fruit juices with transporter-mediated absorption of drugs. DRUG METABOLISM REVIEWS. 2011. 43. 54

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Books (4)：

Agricultural Biotechnology
2023
Drug Selivery System
2022
臨床薬理の進歩
臨床薬理研究振興財団 2020
臨床薬物動態学
医学書院 2009 ISBN:9784260007061

Lectures and oral presentations (123)：

セロトニン動態/腸内細菌叢に起因した薬物性消化器毒性発現とその個体間変動
(日本薬学会第144年会(ジョイントシンポジウムJS11: 個別化医療に寄与する薬剤学-基礎および臨床/開発の観点から) 2024)
薬物吸収動態シミュレーションがもたらす経口特殊製剤の適正使用: 投与製剤で変わるCYP3A/P-gpの影響
(第33回日本医療薬学会年会(シンポジウム24: 薬物動態の“モデリング&シミュレーション”の活用 -現状と未来-) 2023)
消化管生理学の視点から: 消化管内水分挙動解析に基づく生理学的薬物吸収動態予測モデルの確立とその応用
(日本薬物動態学会第38回年会/第23 回シトクロムP450国際会議国際合同大会(シンポジウム5: ゼロから学ぶ薬物吸収動態学: 経口薬物吸収のPBPK Absorptionモデリング&シミュレーションの成功の秘訣) 2023)
薬物動態/ホルモン/腸内細菌叢の因果解析とオルガノイド技術応用による薬物性消化器毒性予測法の確立
(日本薬剤学会経口吸収FG/日本薬物動態学会吸収DIS 合同研究討論会2022 2022)
Quantitative Analysis of the Impact of Controlled-Release Formulation on Oral Absorption and Bioavailability of P-gp/CYP3A4 Substrates
(4th International Symposium on BA/BE of Oral Drug Products (Session 3) 2022)

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Education (3)：

2004 - 2007 Setsunan University Graduate School of Pharmaceutical Sciences Ph.D.
2002 - 2004 Setsunan University Graduate School of Pharmaceutical Sciences M.S.
1998 - 2002 Setsunan University Faculty of Pharmaceutical Sciences

Professional career (1)：

Ph.D. (Setsunan University)

Work history (11)：

2020/04 - 現在 Tokyo University of Pharmacy and Life Sciences School of Pharmacy
2020/04 - 現在 Kanazawa University Faculty of Pharmacy Associate Professor
2018/04 - 現在 Setsunan University Faculty of Pharmaceutical Sciences
2017/04 - 2020/03 Tokyo University of Pharmacy and Life Sciences School of Pharmacy
2017/04 - 2018/03 University of Hyogo

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Committee career (47)：

2023/04 - 現在 The Pharmaceutical Society of Japan (PSJ) Editorial Board
2023/04 - 現在 YAKUGAKU-ZASSHI Editor (Editorial Board)
2023/04 - 現在 Biological and Pharmaceutical Bulletin Editor (Editorial Board)
2023/03 - 現在 ISSX/JSSX 2024 Meeting Organizing Committee (MOC)
2022/12 - 現在 The Pharmaceutical Society of Japan (PSJ) 18th Young Investigator Symposium on Clinical Pharmaceutical Science, Meeting Organizing Committee

2022/12 - 現在 The Pharmaceutical Society of Japan (PSJ) 18th Young Investigator Symposium on Clinical Pharmaceutical Science, Annual Meeting Organizing Committee, Chair

2022 - 現在 The Japanese Society for the Study of Xenobiotics (JSSX) 38th JSSX Annual Meeting Organizing Committee

2021/12 - 現在 Drug Metabolism and Pharmacokinetics Guest Editor

2021/11 - 現在 The Japanese Society for the Study of Xenobiotics (JSSX) DMPK Activation Committee

2021/04 - 現在 The Academy of Pharmaceutical Science and Technology, Japan (APSTJ) Reiwa's Vision Committee, Chair

2021/04 - 現在 The Academy of Pharmaceutical Science and Technology, Japan (APSTJ) Reiwa's Vision Committee

2021/04 - 現在 Pharmaceutics Topic Editor (Editorial Board)

2021/03 - 現在 Frontiers in Pharmacology Review Editor (Editorial Board)

2020 - 現在 The Academy of Pharmaceutical Science and Technology, Japan (APSTJ) International Exchange Board Committee

2020 - 現在 The Academy of Pharmaceutical Science and Technology, Japan (APSTJ) Journal of Pharmaceutical Science and Technology, Japan (YAKUZAIGAKU) Adviser

2020 - 現在 The Academy of Pharmaceutical Science and Technology, Japan (APSTJ) Oral Absorption Focus Group Vice-chair

2020 - 現在 The Academy of Pharmaceutical Science and Technology, Japan (APSTJ) Oral Absorption Focus Group Committee

2019 - 現在 The Japanese Society for the Study of Xenobiotics (JSSX) Absorption DIS Chair

2019 - 現在 The Japanese Society for the Study of Xenobiotics (JSSX) Absorption DIS Committee

2019 - 現在 The Japanese Society of Digestion and Absorption Councilor

2018 - 現在 The Pharmaceutical Society of Japan Division of Clinical Pharmaceutical Scienses, Young Courier

2017 - 現在 Workshop for Japan-Korea Young Scientists on Pharmaceutics Committee

2017 - 現在 Drug Metabolism and Pharmacokinetics Editorial Advisory Board (EAB)

2016 - 現在 The Academy of Pharmaceutical Science and Technology, Japan (APSTJ) Journal of Pharmaceutical Science and Technology, Japan (YAKUZAIGAKU) Editorial Board

2016 - 現在 The Japanese Society for the Study of Xenobiotics (JSSX) Councilor

2016 - 現在 The Academy of Pharmaceutical Science and Technology, Japan (APSTJ) Councilor

2016 - 現在 The Academy of Pharmaceutical Science and Technology, Japan (APSTJ) Drug Interaction Focus Group Committee

2016 - 現在 Absorption Club Chair

2007 - 現在 Japan Transporter Research Association (JTRA) Committee

2021/11 - 2022/11 The Japanese Society for the Study of Xenobiotics (JSSX) 37th JSSX Annual Meeting Organizing Committee

2021/04 - 2022/03 Japan Transporter Research Association (JTRA) 16th JTRA Annual Meeting Organizing Committee

2020/04 - 2022/03 The Pharmaceutical Society of Japan Hokuriku Branch Annual Meeting Planning Committee

2020/12 - 2021/11 Japan Transporter Research Association (JTRA) Kansai Region Committee

2018/10 - 2020/11 Japan Transporter Research Association (JTRA) Kanto Region Committee

2018 - 2020 The Academy of Pharmaceutical Science and Technology, Japan (APSTJ) Global Education Seminar Comittee Vice-chair

2018 - 2020 Workshop for Japan-Korea Young Scientists on Pharmaceutics Chair

2018 - 2020 The Academy of Pharmaceutical Science and Technology, Japan (APSTJ) Journal of Pharmaceutical Science and Technology, Japan (YAKUZAIGAKU) Editor-in-chief

2016 - 2020 The Academy of Pharmaceutical Science and Technology, Japan (APSTJ) English Seminar Committee

2018/02 - 2019/10 The Japanese Society of Digestion and Absorption 49th Annual Meeting Planning Committee

2018 - 2019 Japan Transporter Research Association (JTRA) Kanto Region Chair

2017 - 2018 Workshop for Japan-Korea Young Scientists on Pharmaceutics Vice-chair

2016 - 2018 The Academy of Pharmaceutical Science and Technology, Japan (APSTJ) Journal of Pharmaceutical Science and Technology, Japan (YAKUZAIGAKU) Vice Editor-in-chief

2014 - 2014 ISSX/JSSX 2014(19th North American ISSX Meeting/29th JSSX Meeting) Short Course Co-Chairs

2010 - 2014 The Academy of Pharmaceutical Science and Technology, Japan (APSTJ) Oral Absorption Focus Group Committee

2008 - 2010 The Academy of Pharmaceutical Science and Technology, Japan (APSTJ) Global Education Seminar (West) Committee

2005 - 2007 The Academy of Pharmaceutical Science and Technology, Japan (APSTJ) SNPEE organizing committee

2005 - 2006 The Academy of Pharmaceutical Science and Technology, Japan (APSTJ) Chair

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Awards (34)：

2023 - JSCPT Best Presentation Award 2023
2023 - JSPHCS Best Presentation Award 2023
2023 - YCPS 2021 Best Presentation Award
2023 - JSOT Best Presentation Award 2023
2023 - 38th APSTJ Best Presentation Award

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Association Membership(s) (14)：

The Japanese Society of Toxicology , Japanese Society of Gout and Uric & Nucleic Acids , The Japanese Society of Clinical Pharmacology and Therapeutics , The American Society for Pharmacology and Experimental Therapeutics , Japanese Society of Pharmaceutical Health Care and Sciences , The Japanese Society of Digestion and Absorption , Forum for Pharmaceutical Technology Innovation , Japan Transporter Research Association , The International Society for the Study of Xenobiotics , The American Association of Pharmaceutical Scientists , The Pharmaceutical Society of Japan , The Academy of Pharmaceutical Science and Technology, Japan , The Japanese Society for the Study of Xenobiotics , The Japanese Gastroenterological Association

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