Rchr
J-GLOBAL ID:200901045379935291   Update date: Jun. 30, 2020

Shirasaka Yoshiyuki

シラサカ ヨシユキ | Shirasaka Yoshiyuki
Homepage URL  (2): http://www.p.kanazawa-u.ac.jp/lab/doutai.htmlhttp://www.p.kanazawa-u.ac.jp/e/lab/doutai.html
Research field  (3): Clinical pharmacy ,  Clinical pharmacy ,  Clinical pharmacy
Research keywords  (9): Pharmacokinetics ,  Biopharmaceutics ,  Drug Absorption ,  Drug Transport ,  Drug Metabolism ,  Drug Interaction ,  Transporters ,  Bioavailability ,  Gastrointestinal Toxicity
Research theme for competitive and other funds  (11):
  • 2017 - 2019 Kinetic Analysis of Gastrointestinal Water Absorption to Quantitatively Predict Drug-Beverage and -Food Interactions
  • 2016 - 2018 Development of in vitro System to Evaluate Oral Drug Absorption Using Intestinal Villus Epithelial Model
  • 2015 - 2016 Quantitative Analysis of the Effect of Controlled-release on Intestinal Absorption of P-gp and CYP3A Substrate Drugs
  • 2015 - 2016 Quantitative Analysis of Site-Dependent Intestinal Absorption of Drugs
  • 2014 - 2014 Kinetic Analysis of Transporters- and Metabolic Enzymes-Mediated Drug Absorption
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Papers (78):
  • Suzuki S, Shirasaka Y, Okada R, Eguchi A, Kishimoto H, Langguth P, Inoue K. Quantitative analysis of the effect of controlled-release formulation on nonlinear gastrointestinal absorption of P-glycoprotein substrate talinolol using physiologically based pharmacokinetic absorption model. Journal of Drug Delivery Science and Technology. 2019
  • Miyazaki K, Kishimoto H, Muratani M, Kobayashi H, Shirasaka Y, Inoue K. Mucins are Involved in the Intestinal Permeation of Lipophilic Drugs in the Proximal Region of Rat Small Intestine. Pharm Res. 2019. 36. 11. 162
  • Funai Y, Shirasaka Y, Ishihara M, Takemura M, Ichijo K, Kishimoto H, Inoue K. Effect of Osmolality on the Pharmacokinetic Interaction between Apple Juice and Atenolol in Rats. Drug Metab Dispos. 2019. 47. 4. 386-391
  • Furuya T, Takehara I, Shimura A, Kishimoto H, Yasujima T, Ohta K, Shirasaka Y, Yuasa H, Inoue K. Organic anion transporter 1 (OAT1/SLC22A6) enhances bioluminescence based on d-luciferin-luciferase reaction in living cells by facilitating the intracellular accumulation of d-luciferin. Biochem Biophys Res Commun. 2018. 495. 3. 2152-2157
  • Yoshiyuki Shirasaka, Nora Lee, Haichuan Duan, Horace Ho, Joanna Pak, Joanne Wang. Interspecies comparison of the functional characteristics of plasma membrane monoamine transporter (PMAT) between human, rat and mouse. JOURNAL OF CHEMICAL NEUROANATOMY. 2017. 83. 99-106
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MISC (5):
  • Yoshiyuki Shirasaka, Amarjit S. Chaudhry, Timothy Wong, Justina C. Calamia, Nina Isoherranen, Allan E. Rettie, Erin G. Schuetz, Kenneth E. Thummel. INTERINDIVIDUAL VARIABILITY OF CYP2C19-CATALYZED DRUG METABOLISM DUE TO DIFFERENCES IN THE DIPLOTYPES. DRUG METABOLISM REVIEWS. 2014. 45. 29-30
  • 小林彰子, 我妻瑶恵, 森本かおり, 叶隆, 和田翔, 白坂善之, 玉井郁巳, 荻原琢男. 消化管吸収過程における薬物とミルクのペプチドトランスポーター(PEPT1)を介した相互作用の解析. 薬剤学. 2010. 70. Supplement. 218-218
  • 我妻瑶恵, 森本かおり, 小林彰子, 叶隆, 和田翔, 白坂善之, 玉井郁巳, 荻原琢男. ペプチドトランスポーター(PEPT1)の基質となる薬物の消化管吸収に与えるミルクの影響. 日本農芸化学会大会講演要旨集. 2010. 2010. 40
  • 小林彰子, 我妻瑶恵, 叶隆, 和田翔, 薮内光, 白坂善之, 森本かおり, 玉井郁巳, 荻原琢男. 食事由来ペプチドがヒトペプチドトランスポーターPEPT1に基質認識される薬物の消化管吸収に与える影響. 日本栄養・食糧学会大会講演要旨集. 2009. 63rd. 149-149
  • 我妻 瑶恵, 叶 隆, 和田 翔, 薮内 光, 白坂 善之, 森本 かおり, 小林 彰子, 玉井 郁巳, 荻原 琢男. オセルタミビルのPEPT1基質認識性と消化管吸収における食事由来ペプチドの影響. 薬剤学: 生命とくすり. 2009. 69. Suppl. 158-158
Lectures and oral presentations  (72):
  • New challenges of pharmaceutical-pharmacokinetic collaboration in innovative drug development
    (32nd APSTJ Annual Meeting 2017)
  • Kinetic Analysis of Physiological Functions of Gastrointestinal Tract to Predict Oral Drug Absorption
    (32nd APSTJ Annual Meeting 2017)
  • Effect of Mucus Layer on the Intestinal Membrane Permeability of Lipophilic Drugs
    (32nd APSTJ Annual Meeting 2017)
  • Development of a Simple Method to Evaluate the Membrane Permeation of Micellized Drug
    (32nd APSTJ Annual Meeting 2017)
  • Utilization of Transporter-Mediated Cellular Uptake of D-Luciferin for in vivo Bioluminescence Imaging
    (32nd APSTJ Annual Meeting 2017)
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Education (3):
  • 2004 - 2007 Setsunan University Graduate School of Pharmaceutical Sciences Ph.D.
  • 2002 - 2004 Setsunan University Graduate School of Pharmaceutical Sciences M.S.
  • 1998 - 2002 Setsunan University Faculty of Pharmaceutical Sciences
Professional career (1):
  • Ph.D. (Setsunan University)
Work history (8):
  • 2020/04 - 現在 Kanazawa University Associate Professor
  • 2017/04 - 2020/03 Tokyo University of Pharmacy and Life Sciences
  • 2015/01 - 2017/03 Tokyo University of Pharmacy and Life Sciences
  • 2014/01 - 2014/12 The Uehara Memorial Foundation Research fellow
  • 2012/01 - 2014/12 University of Washington Visiting Scholar/Scientist
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Committee career (18):
  • 2018 - 現在 The Academy of Pharmaceutical Science and Technology, Japan (APSTJ) Global Education Seminar Comittee Vice-chair
  • 2018 - 現在 Workshop for Japan-Korea Young Scientists on Pharmaceutics Chair
  • 2018 - 現在 The Pharmaceutical Society of Japan Division of Clinical Pharmaceutical Scienses, Young Courier
  • 2018 - 現在 The Japanese Society of Digestion and Absorption 49th Annual Meeting Planning Committee
  • 2018 - 現在 The Academy of Pharmaceutical Science and Technology, Japan (APSTJ) Journal of Pharmaceutical Science and Technology, Japan (YAKUZAIGAKU) Editor-in-chief
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Awards (15):
  • 2018 - PSJKB Award for Young Pharmaceutical Scientist 2018
  • 2017 - APSTJ Award for Young Pharmaceutical Scientist 2017
  • 2015 - JSSX Award for Young Scientists 2015
  • 2013 - 10th International ISSX Poster Award, Finalist
  • 2013 - APSTJ Global Education Seminar Presentation Award 2013
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Association Membership(s) (10):
Japanese Society of Pharmaceutical Health Care and Sciences ,  Forum for Pharmaceutical Technology Innovation ,  Japan Transporter Research Association ,  The International Society for the Study of Xenobiotics ,  The American Association of Pharmaceutical Scientists ,  The Japanese Society of Digestion and Absorption ,  The Pharmaceutical Society of Japan ,  The Academy of Pharmaceutical Science and Technology, Japan ,  The Japanese Society for the Study of Xenobiotics ,  The American Society for Pharmacology and Experimental Therapeutics
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