Ohno Hiroaki

オオノヒロアキ | Ohno Hiroaki

Affiliation and department：
Homepage URL (1)： http://www.pharm.kyoto-u.ac.jp//seizo/

Research field (2)： Pharmaceuticals - chemistry and drug development , Bioorganic chemistry

Research keywords (4)： Cascade reactions , Sythetic Organic Chemistry , Natural Product Chemistry , Medicinal Chemistry

Research theme for competitive and other funds (30)：

2023 - 2027 Natural product syntheses based on cascade cyclization and their applications to middle-molecule drug modalities
2022 - 2024 Synthesis of Novel Bowl-Shaped Highly pi-Conjugated Molecules Based on the Original Vinylcation Formation
2017 - 2021 Synthetic and medicinal studies on bioactive indole alkaloids based on direct construction of polycyclic ring systems
2018 - 2020 Alkaloid Synthesis and Its Middle Molecular Strategy Based on Reaction Integration
2015 - 2019 Precise activation based on transition state control using neighboring effect and its medicinal application

2015 - 2018 Develoment of a screening platform using mirror-image proteins and their application to drug discovery

2015 - 2018 Development of Novel Drug Discovery Technologies for Target Proteins with Elusive Molecular Basis

2012 - 2017 Innovative Molecular Transformations Based on Consecutive pai-Activation and Their Medicinal Applications

2012 - 2015 Development and application of a novel screening technolgy toward effective uses of chemical library

2011 - 2015 Practical medicinal chemistry on the basis of protein chemistry, computational science and synthetic technologies for a variety of heterocycles

2012 - 2014 原子移動型反応の高度集積化による多環式芳香族化合物の合成と創薬展開

2010 - 2011 触媒的多成分反応・高原子効率反応の高度集積化と創薬展開

2010 - 2011 Divergent syntheses of biologically active compounds based on catalytic cascade cyclization reactions

2008 - 2009 多重標的創薬概念に基づくがん化学療法の新機軸

2008 - 2009 GPCR周辺の細胞外環境解明のためのケミカルプローブの創出と応用

2007 - 2009 Development of highly atom-economical synthetic methods based on catalytic cascade reactions

2006 - 2007 癌転移・骨髄依存薬物耐性の動的超分子機構解明のケミカルプローブ創出と創薬展開

2006 - 2007 ドラッグ指向性化合物バンクの構築と創薬展開

2005 - 2006 複雑な構造を有する生物活性複素環の一挙合成法の開発と環境調和型連続反応への展開

2003 - 2004 パラジウム触媒を用いた新規反応活性種の創出と合成反応への利用

2003 - 2004 生物活性を有する含窒素複素環の自在な合成を指向した新規環形成反応の開発研究

2001 - 2002 Synthesis of Biologically Active Compounds Using Potential Utility of Transition Metals

2000 - 2001 高活性な降圧剤及びプロテアーゼ阻害剤の開発を指向したアミノアレンの合成研究

1999 - 1999 高活性なプロテアーゼ阻害剤及び糖尿病治療薬の開発を指向した基礎的合成研究

触媒的・連続型反応の開発

遷移金属を用いた触媒的・連続型反応の開発

遷移金属を用いた複素環合成反応の開発

Catalytic and Tandem Reactions

Development of Transition Metal-Catalyzed Tandem Reactions

Heterocycle Syntheses Using Transition Metals

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Papers (281)：

Shinsuke Inuki, Junki Miyamoto, Naoki Hashimoto, Hidenori Shimizu, Hitomi Tabuchi, Atsuko Kawai, Luca C. Greiner, Ikuo Kimura, Hiroaki Ohno. Structure-activity relationship studies of tetrahydroquinolone derivatives as GPR41 modulators. Bioorganic & Medicinal Chemistry Letters. 2024. 107. 129758-129758
Naoya Iwamoto, Takuma Kai, Shinsuke Inuki, Hiroaki Ohno, Hitoshi Maeda, Hiroshi Watanabe, Toru Maruyama, Shinya Oishi. Mirror-Image Human Serum Albumin Domain III as a Tool for Analyzing Site II-Dependent Molecular Recognition. Bioconjugate Chemistry. 2024
Keisuke Aoki, Shugo Tsuda, Naoko Ogata, Michiyo Kataoka, Jumpei Sasaki, Shinsuke Inuki, Hiroaki Ohno, Koichi Watashi, Taku Yoshiya, Shinya Oishi. Synthesis of the full-length hepatitis B virus core protein and its capsid formation. Organic & biomolecular chemistry. 2024. 22. 11. 2218-2225
Ayuta Yamaguchi, Naoki Obiya, Norihito Arichi, Shinya Oishi, Hiroaki Ohno, Shinsuke Inuki. Synthesis of labionin and avionin precursors via a nitrogen-centred-radical-triggered 1,5-HAT reaction of Tris derivatives. Organic & biomolecular chemistry. 2024. 22. 10. 2049-2055
Naoya Iwamoto, Jumpei Sasaki, Saya Ohno, Keisuke Aoki, Yusuke Usui, Shinsuke Inuki, Hiroaki Ohno, Shinya Oishi. Synthetic studies on the extracellular domain of the T cell immunoreceptor with immunoglobulin and immunoreceptor tyrosine-based inhibitory motif domain (TIGIT) using Trt-K10 solubilizing tags. Bioorganic & medicinal chemistry. 2024. 99. 117585-117585

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MISC (185)：

山口亞由太, 井貫晋輔, 有地法人, 大石真也, 大野浩章. Construction of Quaternary Carbon Stereocenter of α-Tertiary Amine of Avionin Moiety and Synthetic Study of Microvionin. 日本薬学会年会要旨集(Web). 2023. 143rd
岩本直也, 佐々木順平, 青木啓輔, 井貫晋輔, 大野浩章, 大石真也, 大石真也. Synthetic Study of Imuune Checkpoint Molecules. 日本薬学会年会要旨集(Web). 2023. 143rd
佐藤志乃, 岩本直也, 眞鍋麻彩子, 井貫晋輔, 大野浩章, 野中元裕, 大石真也. Synthetic Studies on Mirror-image Monobody and Their Application to a Novel Antibody Mimetic. 日本薬学会年会要旨集(Web). 2023. 143rd
眞鍋麻彩子, 前田佳夕, 青木啓輔, 薄井友輔, 高橋里菜, 大野浩章, 森瀬譲二, 岡昌吾, 大石真也, 野中元裕. 鏡像VHH抗体の免疫原性評価と免疫ライブラリーを用いた配列取得. 日本生化学会大会(Web). 2022. 95th
松岡巧朗, 服部明, 大石真也, 有地法人, 掛谷秀昭, 山崎晶, 山崎晶, 大野浩章, 井貫晋輔. Identification of a novel MR1 ligand by screening with split-luciferase and its structure-activity relationship study. メディシナルケミストリーシンポジウム講演要旨集. 2022. 39th (CD-ROM)

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Patents (4)：

Books (4)：

Intramolecular C-X Bond Formation between C=X or X-H and Alkynes (in Transition-Metal-Mediated Aromatic Ring Construction)
Wiley 2013
Synthesis by Substitution (in Science of Synthesis)
Thieme 2007
Vinylaziridines in Organic Synthesis (in Aziridines and Epoxides in Organic Synthesis)
Wiley-VCH 2005
Enantioselective Synthesis of Allenes (in Modern Allene Chemistry)
Wiley-VCH 2004

Lectures and oral presentations (36)：

Gold-Catalyzed Cascade Cyclization for Fused Ring Construction
(The 8th Japanese-Sino Symposium on Organic Chemistry for Young Scientists 2019)
Gold-Catalyzed C-C bond Formation and Its Application to Alkaloid Synthesis
(Technische Universität Wien Special Lecture 2019)
Gold-Catalyzed Cascade Cyclization Reactions via C-H Bond Cleavage
(The 47th Naito Conference 2019)
Gold-Catalyzed C-C bond Formation and Its Application to Alkaloid Synthesis
(1st NCTU Conference on Advanced Organic Synthesis 2018)
天然物骨格一挙構築法の開発と応用
(京大テックフォーラム 2018)

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Education (4)：

1998 - 1999 Kyoto University
1996 - 1999 Kyoto University
1992 - 1996 Kyoto University Faculty of Pharmaceutical Sciences
1989 - 1992 函館ラ・サール高等学校

Professional career (1)：

Doctor (Phamaceutical Sciences) (Kyoto University)

Work history (6)：

2019/04/01 - Institute for Liberal Arts and Sciences/Graduate School of Pharmaceutical Sciences, Kyoto University Professor
2015/04 - 2019/03 Kyoto University ILAS/Graduate School of Pharmceutical Sciences Professor
2008/04/01 - Graduate School of Pharmaceutical Sciences, Kyoto University Associate Professor
2005/07/01 - Graduate School of Pharmaceutical Sciences, Kyoto University Associate Professor
1999/09/16 - Graduate School of Pharmaceutical Sciences, Osaka University Assistant Professor

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Awards (5)：

2013/11 - MSD Life Science Foundation Banyu Chemist Award Molecular architecture based on consecutive efficient transformations and its application to drug discovery
2006/11 - Kansai Branch, The Society of Synthetic Organic Chemistry Kansai Branch Award, The Society of Synthetic Organic Chemistry
2005/03 - The Pharmaceutical Society of Japan The Pharmaceutical Society of Japan Award for Young Scientists Development of Useful Reactions Involving Tandem Cyclizations Based on the Novel Reactivities of Allenic Compounds
2001/06 - Kinki Branch, the Pharmaceutical Society of Japan Kinki Branch Award for Encouragement of Research, the Pharmaceutical Society of Japan
2001 - The Pharmaceutical Society of Japan, Kinki Branch Award for Young Scientists

Association Membership(s) (3)：

The Japanese Peptide Society , The Society of Synthetic Organic Chemistry, Japan , The Pharmaceutical Society of Japan

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