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J-GLOBAL ID：200901045612362078   Update date: Jan. 27, 2025

MURAKAMI Takashi

ムラカミ タカシ | MURAKAMI Takashi
Affiliation and department：
Saitama Medical University Faculty of Medicine

About Saitama Medical University Faculty of Medicine


Job title： Professor
Research field  (1)： Tumor diagnostics and therapeutics
Research theme for competitive and other funds  (22)：
  • 2024 - 治療抵抗性「パーシスター」メラノーマ細胞も発生機序の解明とその治療標的化
  • 2021 - 2024 細菌の嫌気部位集積性を利用した悪性黒色腫に対する新規免疫誘導方法の開発
  • 2022 - 進行性メラノーマの腫瘍免疫原性再プログラム化とその分子標的研究
  • 2017 - 2020 新規免疫チェックポイント分子DC-HILを標的としたがん治療の研究
  • 2016 - 2020 ヒトへの外挿性を向上させた培養細胞資源開発と供給体制整備 (AMED)
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Papers (201)：
  • Hyperdifferentiated murine melanoma cells promote adaptive anti-tumor immunity but activate the immune checkpoint system. 2024. 14. 1. 2437211
  • Hanitrarimalala V, Bednarska I, Murakami T, Papadakos KS, Blom AM. Intracellular cartilage oligomeric matrix protein augments breast cancer resistance to chemotherapy. Cell Death Dis. 2024. 15. 7. 480.
  • Owaki T, Iida T, Miyai Y, Kato K, Hase T, Ishii M, Ando R, Hinohara K, Akashi T, Mizutani Y, et al. Synthetic retinoid-mediated preconditioning of cancer-associated fibroblasts and macrophages improves cancer response to immune checkpoint blockade. Br J Cancer. 2024. 131. 2. 372-386
  • Ichikawa T, Suekane A, Nakahata S, Iha H, Shimoda, K, Murakami T, Morishita K. Inhibition of PRMT5/MEP50 arginine methyltransferase activity causes cancer vulnerability in NDRG2low Adult T-cell leukemia/lymphoma. Int J Mol Sci. 2024. 25. 2. 2842
  • Horiuchi Y, Nakamura A, Imai T, Murakami T. Infection of tumor cells with Salmonella typhimurium mimics immunogenic cell death and elicits tumor-specific immune responses. PNAS Nexus. 2024. 3. 1. pgad484
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MISC (63)：
  • Aya Matsui, Takashi Murakami, Taichi Ezaki. Expression of CXCL17 in tumors promotes their progression by inducing CXCL17-responding CD11b(+) Gr-1(high) cells. ANGIOGENESIS. 2014. 17. 3. 745-745
  • 小俣 大樹, 根岸 洋一, 村上 孝, 野水 基義, 新槙 幸彦. ラミニン由来AG73ペプチド修飾リポソームによるsiRNA導入効率の評価. 日本薬学会年会要旨集. 2010. 130年会. 4. 271-271
  • 井上 泰一, 村上 孝, 遠藤 照顕, 小林 英司, 星野 雄一. 糖尿病ラットに対する人工真皮のscaffoldとしての有用性. 日本整形外科学会雑誌. 2009. 83. 8. S1058-S1058
  • Profile of GFP-transgenic Jinhua Pigs (1) Growth and reproductive performance, and GFP expression in tissues. Bulletin of Shizuoka Prefectural Research Institute of Animal Industry, Swine & Poultry Research Center. 2009. 2. 1-7
  • 井上 泰一, 村上 孝, 安食 孝士, 遠藤 照顕, 小林 英司, 星野 雄一. 糖尿病ラットにおける骨髄由来細胞付加人工真皮の創傷治癒メカニズム. 日本整形外科学会雑誌. 2008. 82. 8. S1183-S1183
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Books (13)：
  • 「免疫力が高まる27の生活習慣」
    (株)法研 2020
  • 生物発光モデル動物作製によるがん生物学研究(27章)「がんの分子イメージング」
    化学同人 2015
  • CXCL17 (chemokine (C-X-C motif) ligand 17),Atlas Genet Cytogenet Oncol Haematol
    Institute for Scientific and Technical Information of the French National Center for Scientific Research (INIST-CNRS) 2015
  • Immunomodulation Therapy by the Control of Immune Cell Trafficking (Chapter 10).,Current Immunosuppressive Therapy in Organ Transplantation
    Nova Science Publishers, Inc 2015
  • Immunomodulation Therapy by the Control of Immune Cell Trafficking (Chapter 10). Current Immunosuppressive Therapy in Organ Transplantation
    Nova Science Publishers, Inc 2015
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Lectures and oral presentations  (8)：
  • 細菌を介した生体防御調節と腫瘍免疫への応用
    (第59回日本臨床分子医学会学術集会 2024)
  • Fusobacterium nucreatum promotes epithelial-mesenchymal transition in murine NMuMG breast cancer cells
    (第82回日本癌学会学術総会 2023)
  • Salmonella infected-melanoma cells elicit anti-melanoma T-cell responses.
    (第50回日本免疫学会学術集会 2021)
  • Activation of antigen-presenting cells by stress-induced senescence-like tumor cells.
    (第50回日本免疫学会学術集会 2021)
  • Intra-cellular infection of tumor with Salmonella typhimurium primes tumor-antigen specific T-cell responses.
    (第80回日本癌学会学術総会 2021)
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Education (2)：
  • 1993 - 1997 The University of Tokyo Graduate School, Division of Medical Sciences
  • 1986 - 1992 Gunma University Faculty of Medicine
Professional career (1)：
  • 博士(医学) (東京大学大学院)
Work history (9)：
  • 2016/04 - 現在 Gunma University Faculty of Medicine
  • 2011/04 - 2016/08 Professor
  • 2007/04 - 2011/03 Associate Professor
  • 2003/09 - 2007/03 Lecturer
  • 2001/12 - 2003/08 米国 National Cancer Institute (National Institute of Health) 研究員・ポスドク
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