Rchr
J-GLOBAL ID:200901045801866001   Update date: May. 21, 2024

Kitagawa Motoo

キタガワ モトオ | Kitagawa Motoo
Affiliation and department:
Job title: Chiba University
Homepage URL  (1): https://narita.iuhw.ac.jp/staff/igakubu/3095.html
Research field  (1): Medical biochemistry
Research keywords  (2): Signal transduction ,  Notch signaling
Research theme for competitive and other funds  (17):
  • 2019 - 2022 Notch受容体の細胞表面における活性化調節機構
  • 2016 - 2020 Functions of regulators for Notch signaling, almondex/TM2D3
  • 2012 - 2017 Elucidation of interactive mechanism on wound healing process after low temperature plasma treatment
  • 2012 - 2014 Involvement of a co-factor of Notch signaling, Mastermind, into Schizophrenia
  • 2010 - 2012 Fragmented hyaluronan is an autocrine factor potentiating cancer cell invasion supported by HAS2 -CD44/hyaluronidase-2 system on the plasma membrane
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Papers (62):
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MISC (30):
  • 北川元生, 増田渉, 増田渉, 山川智子, 安島理恵子, 三宅克也, 板橋匠美, 梅宮敏文, 梅宮敏文, 東和彦, et al. Transmembrane2domain containing3(TM2D3)はNotch受容体の細胞表面の発現を制御する. 日本分子生物学会年会プログラム・要旨集(Web). 2020. 43rd
  • 北川 元生, 増田 渉, 山川 智子, 安島 理恵子, 三宅 克也, 梅宮 敏文, 東 和彦, 田丸 淳一, 相賀 裕美子, 松野 健治. TM2 domain containing 3(TM2D3)はNotch受容体の細胞表面の発現を制御する. 国際医療福祉大学学会誌. 2019. 24. 抄録号. 171-171
  • Asuka Kawano, Satoshi Ota, Takashi Oide, Jun Matsushima, Masaki Suzuki, Masami Iwamoto, Takashi Kishimoto, Motoo Kitagawa, Nobuyuki Araki, Sonoko Misawa, et al. POEMS Syndrome: A Study of Five Autopsy Cases With Emphasis on the Significance of Subcutaneous Calciphylaxis. LABORATORY INVESTIGATION. 2015. 95. 6A-6A
  • 北川 元生. Notchシグナルの分子機構の研究 Mastermindを中心として. 千葉医学雑誌. 2011. 87. 6. 259-266
  • Kenichi Harigaya, Teruyoshi Saito, Kazuhiko Azuma, Toshifumi Umemiya, Akihiro Toyoda, Yuki Shida, Motoo Kitagawa. CD44 has dual functions to enhance the hyaluronan-induced chemokinesis in cancer cells as an associated molecule of hyaluronidase2-mediated HA catabolism and a hyaluronan receptor for RhoGTPase activation. CANCER RESEARCH. 2011. 71
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Lectures and oral presentations  (5):
  • POEMS Syndrome: A Study of Five Autopsy Cases With Emphasis on the Significance of Subcutaneous Calciphylaxis
    (LABORATORY INVESTIGATION 2015)
  • CD44 has dual functions to enhance the hyaluronan-induced chemokinesis in cancer cells as an associated molecule of hyaluronidase2-mediated HA catabolism and a hyaluronan receptor for RhoGTPase activation
    (CANCER RESEARCH 2011)
  • Fragmented hyaluronan is an autocrine chemokinetic motility factor supported by HAS2-CD44/hyaluronidase-2 system on the plasma membrane
    (INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE 2010)
  • Anti-oncogenic and oncogenic potentials of interferon regulatory factors-1 and -2.
    (J. Interferon Res. 1993)
  • IRF-1 and IRF-2 ; A link between interferon system and the regulation of cell growth.
    (J.Interferon Res. 1992)
Works (7):
  • The role of TM2D proteins in the Notch signaling pathway and amyloid cascade
    2013 - 現在
  • The role of Mastermind proteins in the Notch signaling pathway
    1999 - 現在
  • Notchシグナル伝達系におけるMastermindタンパク質の役割
    1999 - 現在
  • Molecular mechanisms of tumorigenesis and tumor suppression
  • Intracellular signal transduction
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Education (2):
  • 1986 - 1990 Tohoku University
  • 1980 - 1986 Tohoku University Faculty of Medicine
Professional career (2):
  • (BLANK) (Tohoku University)
  • (BLANK) (東北大学)
Work history (11):
  • 2017/04 - 現在 International University of Health and Welfare School of Medicine Professor
  • 2023/10 - 2024/03 Kyushu University Institute for Materials Chemistry and Engineering
  • 2007/04 - 2017/03 Chiba University Graduate School of Medicine Associate Professor
  • 2001/04 - 2007/03 Chiba University Graduate School of Medicine Associate Professor
  • 1998/04 - 2001/03 Chiba University School of Medicine Associate Professor
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Awards (1):
  • 2010 - 千葉医学会 第二回千葉医学会賞
Association Membership(s) (5):
THE JAPANESE BIOCHEMICAL SOCIETY ,  American Society for Biochemistry and Molecular Biology ,  日本癌学会 ,  American Society for Microbiology ,  日本分子生物学会
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