Hata Kenji

ハタケンジ | Hata Kenji

Affiliation and department：
Job title： Associate Professor

Research field (1)： Molecular biology

Research keywords (6)： Bone formation , osteoblast , epigenetics , transcription factor , chondrocyte , Endochondral bone formation

Research theme for competitive and other funds (32)：

2024 - 2027 高齢マウスの骨膜・軟骨膜内に存在する骨軟骨前駆細胞の同定と骨軟骨修復への利用
2023 - 2027 炎症性ドライバーIκBζの相反性の理解から挑む自己免疫疾患の発症機序の解明と応用
2022 - 2026 軟骨細胞分化の連続性を制御する階層的遺伝子発現ネットワークの解明
2021 - 2024 転写プラットフォーム因子Zfhxファミリーによる骨格形成の時空間的制御機構の解明
2021 - 2024 軟骨膜に含まれる骨軟骨前駆細胞の同定と、軟骨再生および骨損傷修復への応用

2020 - 2024 乳酸シャトルによる骨転移進展の制御

2021 - 2024 時空間的トランスクリプトミクスによる骨格系幹細胞の運命決定機構の解明

2019 - 2023 骨・軟骨破壊性疾患の分子標的治療薬の創薬基盤構築を目指す骨免疫学の新機軸の創出

2019 - 2022 The mechanism of bone formation by DNA methylation and its application

2019 - 2021 The elucidation of transcriptional network controlling skeletal development by genome wide analysis

2016 - 2021 Development of innovative medical technology based on integrated understanding of both protection and destruction of articular cartilage homeostasis.

2017 - 2020 Role of sensory nerve in cancer progession

2017 - 2019 Novel strategy of direct reprogramming into chondrocyte

2016 - 2018 Investigation of transcriptional network system of chondrocytes by novel gene-editing cloning technique

2016 - 2018 Establishment of system for predicting inflammatory diseases

2015 - 2017 Development of a novel mouse model that recapitulates bone invasion of oral cancer

2014 - 2017 Biological crosstalk between cancer and bone during bone metastasis

2013 - 2017 Epigenetic regulation underlying bone and cartilage regenaration

2014 - 2016 Development of a novel mouse model that recapitulates bone metastasis seen in human.

2014 - 2016 Development of screening system for bone forming reagents by using TALEN genome engineering technique

2014 - 2016 Search of the cell type-specific inflammatory response

2013 - 2016 Functional role and regulatory mechanism of transcription factor Osterix in skeletal development

2012 - 2014 Establishment of a novel screening system to isolate PTH-like osteogenic small compounds

2011 - 2014 Molecular mechanim of cancer-associated bone pain caused by protons

2011 - 2012 Identification of genes involved in biological crosstalk between cancer and bone

2011 - 2012 Role of Sox9 transcriptional network during chondrocyte differentiation

2010 - 2012 Understanding of non-canonical Wnt signaling network in bone and cartilage formation

2010 - 2011 Investigation for development of technique reprogramming of mesenchymal stem cells using epigenetic analyses

2008 - 2010 Integrative Study of transcriptional network systems during enchondral ossification

2007 - 2009 Understanding of molecular basis by which Indian hedgehog signaling regulates osteoblast differentiation

2007 - 2009 Transcruptional Regulation of Sox9 during endochondral ossification

2003 - 2005 デンタルインプラントにおけるオッセオインテグレーションの分子メカニズムの解明

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Papers (92)：

Naoya Saeki, Chizuko Inui-Yamamoto, Yuki Ikeda, Rinna Kanai, Kenji Hata, Shousaku Itoh, Toshihiro Inubushi, Shigehisa Akiyama, Shinsuke Ohba, Makoto Abe. Deletion of Trps1 regulatory elements recapitulates postnatal hip joint abnormalities and growth retardation of Trichorhinophalangeal syndrome in mice. Human Molecular Genetics. 2024
Sachi Ichiyama-Kobayashi, Kenji Hata, Kanta Wakamori, Yoshifumi Takahata, Tomohiko Murakami, Hitomi Yamanaka, Hiroshi Takano, Ryoji Yao, Narikazu Uzawa, Riko Nishimura. Chromatin profiling identifies chondrocyte-specific Sox9 enhancers important for skeletal development. JCI insight. 2024. 9. 11
Katsutoshi Hirose, Yumiko Hori, Michio Ozeki, Daisuke Motooka, Kenji Hata, Shinichiro Tahara, Takahiro Matsui, Masaharu Kohara, Kazuaki Maruyama, Kyoko Imanaka-Yoshida, et al. Comprehensive phenotypic and genomic characterization of venous malformations. Human Pathology. 2024
Tomohiko Murakami, Lerdluck Ruengsinpinya, Yoshifumi Takahata, Yuri Nakaminami, Kenji Hata, Riko Nishimura. HOXA10 promotes Gdf5 expression in articular chondrocytes. Scientific reports. 2023. 13. 1. 22778-22778
Tatsuo Okui, Masahiro Hiasa, Kenji Hata, G David Roodman, Masako Nakanishi, Toshiyuki Yoneda. The acid-sensing nociceptor TRPV1 controls breast cancer progression in bone via regulating HGF secretion from sensory neurons. Research square. 2023

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MISC (77)：

村上智彦, 高畑佳史, 波多賢二, 中南友里, 西村理行. 骨軟骨形成におけるGタンパク質サブユニットβ1の機能解析. 日本骨代謝学会学術集会プログラム抄録集(CD-ROM). 2022. 40th
波多賢二, 高畑佳史, 村上智彦, 西村理行, 米田俊之. 乳酸受容体GPR81は骨における乳がん細胞の増殖を制御する. 日本骨代謝学会学術集会プログラム抄録集(CD-ROM). 2022. 40th
小林紗知, 小林紗知, 波多賢二, 高畑佳史, 村上智彦, 西村理行. 軟骨細胞におけるSox9遺伝子のエンハンサー領域の同定と機能解析. 日本骨代謝学会学術集会プログラム抄録集(CD-ROM). 2021. 39th
ルゥァンシンピンヤールードラック, 中村恵理子, 高畑佳史, 波多賢二, 中南友里, 西村理行, 村上智彦. GNB1(G protein subunit β1)is required for the late stage of endochondral ossification. 日本骨代謝学会学術集会プログラム抄録集(CD-ROM). 2020. 38th
高畑佳史, 中村恵理子, 萩野弘将, 村上智彦, 波多賢二, 西村理行. 転写因子Runx2の新規標的遺伝子Smoc1,Smoc2による骨形成制御機構の解明. 日本骨代謝学会学術集会プログラム抄録集(CD-ROM). 2020. 38th

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Lectures and oral presentations (4)：

軟骨細胞におけるSox9 遺伝子のエンハンサー領域の同定と機能解析
(第39回日本骨代謝学会 2021)
Identification of Chondrocyte-specific Sox9 Enhancers Important for Skeletal Development
(ASBMR 2021 Annual Meeting 2021)
軟骨細胞におけるSox9遺伝子の発現制御機構の解明
(第6回日本骨免疫学会)
Dmrt2 promotes transition of endochondral ossification by linking Sox9 and Runx2
(European Calcified Tissue Society Congress 2021 2021)

Awards (4)：

2020/10 - 日本骨代謝学会学術賞
2015/03 - 日本軟骨代謝学会学会賞
2013/03 - 日本骨代謝学会研究奨励賞
2001/09 - American Society for Bone and Mineral Research Young Investigator Award

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