Toyoda Futoshi

トヨダフトシ | Toyoda Futoshi

Affiliation and department：
Job title： Assistant Professors

Research field (1)： Physiology

Research theme for competitive and other funds (15)：

2021 - 2024 L型Caチャネルのイオン透過機構と心臓ペースメーカー細胞の持続性内向き電流
2020 - 2023 細胞膜イオンチャネルの網羅的解析による関節変性疾患診断法および抑制療法の開発
2017 - 2020 洞房結節細胞のCav1.3-TRPM4機能連関と持続性内向き電流の分子機構の解明
2014 - 2018 洞房結節におけるCav1.3レアバリアントと持続性内向き電流の関連性の検討
2014 - 2017 Analysis of single anion channel activity in chondrocytes in vitro

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Papers (84)：

Yixin Zhang, Futoshi Toyoda, Yukiko Himeno, Akinori Noma, Akira Amano. Cell-specific models of hiPSC-CMs developed by the gradient-based parameter optimization method fitting two different action potential waveforms. Scientific Reports. 2024. 14. 1
Makiyama Takeru, Gao Jingshan, Yamamoto Yuta, Kobayashi Takuya, Takanori Aizawa, Huang Hai, Kasahiwa Asami, Imamura Tomohiko, Aoki Hisaaki, Kato Koichi, et al. 心疾患の発症機構解明と新たな治療戦略 iPS細胞を用いたカルモジュリン遺伝子異常による致死性不整脈疾患の病態解明(Elucidation of the pathogenesis of heart diseases and development of new therapeutic strategies Modeling calmodulin-related life-threatening arrhythmias using iPS cells). The Journal of Physiological Sciences. 2024. 74. Suppl.2. 99-99
熊谷康佑, 豊田太, 久保充彦, 奥村法昭, 三村朋大, 彌山峰史, 齋藤英貴, 天野泰孝, Battulga Khaltar, 今井晋二. 家兎関節軟骨細胞においてCOX-2選択的阻害剤は薬剤誘導性細胞アポトーシスを抑制する. 日本整形外科学会雑誌. 2023. 97. 8. S1755-S1755
熊谷康佑, 豊田太, 奥村法昭, Battulga Khaltar, 三村朋大, 彌山峰史, 齋藤英貴, 天野泰孝, 久保充彦, 今井晋二. 膝関節由来滑膜線維芽細胞を用いた関節変性疾患における疾患別サイトカイン発現解析. 日本整形外科学会雑誌. 2023. 97. 8. S1860-S1860
Jingshan Gao, Takeru Makiyama, Yuta Yamamoto, Takuya Kobayashi, Hisaaki Aoki, Thomas L Maurissen, Yimin Wuriyanghai, Asami Kashiwa, Tomohiko Imamura, Takanori Aizawa, et al. Novel Calmodulin Variant p.E46K Associated With Severe Catecholaminergic Polymorphic Ventricular Tachycardia Produces Robust Arrhythmogenicity in Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes. Circulation. Arrhythmia and electrophysiology. 2023. 16. 3. e011387

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MISC (54)：

野間昭典, 姫野友紀子, 糀谷泰彦, 豊田太, 幸田茂也, 天野晃. 心筋細胞活動電位数理モデルを実験まく電位記録に合わせる自動パラメータ最適化. 日本生理学雑誌(Web). 2022. 84. 1
KASHIWA Asami, MAKIYAMA Takeru, KOUJITANI Hirohiko, YAMAMOTO Yuta, YAMAMOTO Yuta, GAO Jingshan, HUANG Hai, IMAMURA Tomohiko, AIZAWA Takanori, ISHIKAWA Taisuke, et al. Late Sodium Current Inhibitor Shortens Prolonged Action Potential Durations in iPS Cell-derived Cardiomyocytes of long QT syndrome associated with Cav 1.2 Ion Selectivity Disruption. Journal of Physiological Sciences (Web). 2021. 71. Supplement 1
KOHJITANI Hirohiko, KASHIWA Asami, MAKIYAMA Takeru, ISHIKAWA Taisuke, TOYODA Futoshi, OHNO Seiko, HUANG Hai, GAO Jingshan, IMAMURA Tomohiko, AIZAWA Takanori, et al. Usefulness of Collaboration Between Mathematical Models and Cell Engineering for Elucidating Complex Disease Mechanisms and Discover Effective Drugs. 日本不整脈心電学会学術大会プログラム・抄録集(Web). 2021. 67th
KASHIWA Asami, MAKIYAMA Takeru, KOHJITANI Hirohiko, MAURISSEN Thomas, WURIYANGHAI Yimin, YAMAMOTO Yuta, GAO Jingshan, HUANG Hai, IMAMURA Tomohiko, AIZAWA Takanori, et al. Inhibition of Late Sodium Current Shortens Action Potential Durations in CACNA1C-E1115K iPS Cell Model with Disrupted Cav1.2 Ion Selectivity. 日本不整脈心電学会学術大会プログラム・抄録集(Web). 2021. 67th
MAKIYAMA Takeru, GAO Jingshan, YAMAMOTO Yuta, KASHIWA Asami, AIZAWA Takanori, IMAMURA Tomohiko, HUANG Hai, KOHJITANI Hirohiko, KATO Kouichi, ISHIKAWA Taisuke, et al. Modeling Inherited Arrhythmias Associated with Ryanodine Receptor Dysfunction Using iPS Cells. 日本循環器学会学術集会(Web). 2021. 85th

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Professional career (1)：

博士(農学) (京都大学)

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