Rchr
J-GLOBAL ID：200901046402215915   Update date: Nov. 18, 2024

Yoichiro Abe

アベ ヨウイチロウ | Yoichiro Abe
Affiliation and department：
Keio University School of Medicine Department of Pharmacology

About Keio University School of Medicine Department of Pharmacology


Job title： Research Associate/Assistant Professor/Instructor
Research field  (2)： Pharmacology ,  Molecular biology
Research keywords  (4)： neuromyelitis optica ,  neurodegenerative dieseases ,  astrocyte ,  aquaporin-4
Research theme for competitive and other funds  (9)：
  • 2017 - 2019 アクアポリン4機能と脳リンパ排泄機構に着目したアルツハイマー病発症機構の解明
  • 2016 - 2019 視神経脊髄炎の動物モデルと抗アクアポリン4抗体を用いた新規治療法の開発基盤研究
  • 2015 - 2018 Development of a new therapy for brain edema: study for regulation of AQP4 as a molecular target
  • 2013 - 2015 アルツハイマー病モデルマウスを用いたAβ蓄積から神経原繊維変化へ至る機構の解明
  • 2010 - 2013 アクアポリン4ノックアウトマウスを用いた新規視神経脊髄炎モデルの作製とその解析
Show all
Papers (57)：
  • Kato D, Kameda H, Kinota N, Fujii T, Xiawei B, Simi Z, Takai Y, Chau S, Miyasaka Y, Mashimo T, et al. Loss of aquaporin-4 impairs cerebrospinal fluid solute clearance through cerebrospinal fluid drainage pathways. Scientific reports. 2024
  • Chihiro Namatame, Yoichiro Abe, Yoshiki Miyasaka, Yoshiki Takai, Yuki Matsumoto, Toshiyuki Takahashi, Tomoji Mashimo, Tatsuro Misu, Kazuo Fujihara, Masato Yasui, et al. Humanized-Aquaporin-4-Expressing Rat Created by Gene-Editing Technology and Its Use to Clarify the Pathology of Neuromyelitis Optica Spectrum Disorder. International journal of molecular sciences. 2024. 25. 15
  • Yingqi Wang, Ryosuke Suzuki, Atsushi Fujii, Kenji Ieki, Wakami Goda, Masato Yasui, Yoichiro Abe. A tyrosine-based YXXΦ motif regulates the degradation of aquaporin-4 via both lysosomal and proteasomal pathways and is functionally inhibited by a 10-amino-acid sequence within its C-terminus. The FEBS Journal. 2023. 290. 10. 2616-2635
  • Murakami A, Tsuji K, Isoda M, Matsuo M, Abe Y, Yasui M, Hitoshi Okamura, Tominaga K. Prolonged Light Exposure Induces Circadian Impairment in Aquaporin-4-Knockout Mice. Journal of biological rhythms. 2023. 38. 2. 208-214
  • Akiko Imaizumi, Takayuki Obata, Jeff Kershaw, Yasuhiko Tachibana, Yoichiro Abe, Sayaka Shibata, Nobuhiro Nitta, Ichio Aoki, Masato Yasui, Tatsuya Higashi. Quantitative measurement of diffusion-weighted imaging signal using expression-controlled aquaporin-4 cells: Comparative study of 2-compartment and diffusion kurtosis imaging models. PLOS ONE. 2022. 17. 4
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MISC (15)：
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Lectures and oral presentations  (24)：
  • Development of a new Neuromyelitis Optica model mice.
    (The 18th World Congress of Basic and Clinical Pharmacology/The 91st Annual Meeting of the Japanese Pharmacological Society 2018)
  • Roles of the C-terminal domain in intracellular trafficking and degradation of AQP4.
    (The 40th Annual Meeting of the Molecular Biology Society of Japan 2017)
  • Aquaporin-4 is not involved in chronic neuroinflammatory responses in 5xFAD mice.
    (The 90th Annual Meeting of the Japanese Pharmacological Society 2017)
  • Glial responses to amyloid β accumulation in aquaporin-4-deficient Alzheimer’s disease model.
    (The 39th Annual Meeting of the Japan Neuroscience Society 2016)
  • High avidity chimeric monoclonal antibodies against the extracellular domains of human aquaporin-4 competing with NMO-IgG.
    (The 88th Annual Meeting of the Japanese Pharmacological Society 2015)
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Professional career (1)：
  • 博士(医学) (University of Tsukuba)
Work history (4)：
  • 2009/04/01 - 現在 School of Medicine, Keio University Department of Pharmacology associate professor
  • 2007/04/01 - 2009/03/31 School of Medicine, Keio University Department of Pharmacology Instructor
  • 1999/04/01 - 2007/03/31 School of Medicine, Keio University Department of Pharmacology Instructor
  • 1997/04/01 - 1999/03/30 Institute of Basic Medical Sciences, University of Tsukuba Department of Pharmacology Research Associate
Association Membership(s) (4)：
日本薬理学会 ,  Society for Neuroscience ,  日本神経科学学会 ,  日本分子生物学会
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