2019 - 2024 Novel approach focusing on the tight junction-based paracellular barrier combined with the apical barrier toward understanding and manipulating epithelial barriers
2017 - 2020 Structural and functional analysis of sodium selective permeation of voltage dependent sodium channel
2015 - 2020 Studies in structural physiology of channels
2016 - 2018 局所麻酔薬の作用機構の解明を目指したナトリウムチャネルの構造解析
2002 - 2004 X線結晶構造解析学的手法を用いたHomer1cによる受容体集積機構の解明
Show all
Papers (34):
Ayumi Sumino, Takashi Sumikama, Mikihiro Shibata, Katsumasa Irie. Voltage sensors of a Na+ channel dissociate from the pore domain and form inter-channel dimers in the resting state. Nature Communications. 2023
Katsumasa Irie, Yoshinori Oda, Takashi Sumikama, Atsunori Oshima, Yoshinori Fujiyoshi. The structural basis of divalent cation block in a tetrameric prokaryotic sodium channel. Nature Communications. 2023. 14. 1
Ayumi Sumino, Takashi Sumikama, Mikihiro Shibata, Katsumasa Irie. Interchannel dimerization of the dissociated voltage-sensor domains of voltage-gated Na+ channels in the resting state. Research Square. 2023
Daisuke Kozai, Nobutaka Numoto, Kouki Nishikawa, Akiko Kamegawa, Shohei Kawasaki, Yoko Hiroaki, Katsumasa Irie, Atsunori Oshima, Hiroyuki Hanzawa, Kousei Shimada, et al. Recognition mechanism of a novel gabapentinoid drug, mirogabalin, for recombinant human α2δ1, a voltage-gated calcium channel subunit. Journal of Molecular Biology. 2023. 168049-168049
Ayumi Sumino, Takashi Sumikama, Leonardo Puppulin, Mikihiro Shibata, Katsumasa Irie. Dissociation and inter-channel dimerization of voltage-sensor domains (VSD) of voltage-gated Na+ channel in the resting state. The Journal of Physiological Sciences. 2023. 73. 95
入江 克雅. 細胞膜で躍動するタンパク質複合体の意外な素顔 細菌のカルシウムチャネルが示すカルシウム選択的なイオン透過機構(Unexpected operation mechanism of supramolecular machinery working in cell membrane Bacterial calcium channels indicate the universal mechanism of calcium-selective ion permeation). 日本細菌学雑誌. 2022. 77. 1. 37-37
山本健太, 入江克雅, 藤吉好則, 阿部一啓, 山本健太, 入江克雅, 藤吉好則, 阿部一啓. Structural determinants for the K+-binding stoichiometry in the E2P state of gastric H+,K+-ATPase. 日本生体エネルギー研究会討論会講演要旨集. 2019. 45th
Molecular dynamics simulation and structural analysis of the divalent cation blocking mechanism generated in prokaryotic cation channel
(The 10th Federation of Asian and Oceanian Physiological Societies (FAOPS) Congress 2023)
The structural basis of divalent cation block in a tetrameric prokaryotic sodium channel
(Ion Channel Modulation Symposium - US 2023 in Irvine California 2023)
2022/09 - Biophysical Society of Japan 9th BPPB Editors’ Choice Award The insights into calcium ion selectivity provided by ancestral prokaryotic ion channels
Association Membership(s) (4):
日本薬学会
, 日本細菌学会
, THE PHYSIOLOGICAL SOCIETY OF JAPAN
, THE BIOPHYSICAL SOCIETY OF JAPAN