Rchr

J-GLOBAL ID：200901048460083223 Update date: Jan. 10, 2025

Katayama Tsutomu

カタヤマツトム | Katayama Tsutomu

Affiliation and department：
Job title： Professor
Homepage URL (1)： https://bunsei.phar.kyushu-u.ac.jp

Research field (3)： Genetics , Molecular biology , Functional biochemistry

Research keywords (8)：生物系薬学 , 合成生物学 , 生物化学 , 分子生物学 , Pharmaceutical Molecular Biology , Synthetic Biology , Biological Chemistry , Moleular Biology

Research theme for competitive and other funds (41)：

2021 - 2024 DNA屈曲因子の新たな分子動態解明から切り開く新たな細胞周期像の創出
2020 - 2023 両方向性複製を支える複製開始機構の原理と複製開始制御システムの機能制御原理の解明
2017 - 2020 Molecular mechanisms on the replication initiation which leads to loading of the helicase and the regulatory systems for the replication initiation
2016 - 2018 複製開始蛋白質 DnaAに対する制御系の自律的連動システムの創生と動態原理の解析
2014 - 2017 Genomic and functional analysis for novel long-chain inverted repeats

2014 - 2017 Analysis of molecular association and dissociation mechanism in replication restart

2014 - 2017 Introduction of lactam with useful functions into proteins at specific lysine residue by reactions with artificial nucleic acids

2014 - 2017 Functional regulation for nucleoprotein complexes in the chromosomal replication origin and in novel regulatory elements, DARS and datA

2013 - 2017 Study of mechanisms that decrease speed of replication fork progression in DNA damage response

2013 - 2015 新たな染色体分配因子の運動と機能の分子機構解析

2012 - 2014 Systematic analysis on the inter-gene regions of the Escherichia coli genome

2011 - 2013 Structural basis of replication restart primosome proteins involved in DnaB helicase loading

2010 - 2012 Molecular analyses on the replication initiation complex and its novel regulatory factors in E. coli

2010 - 2011 Analysis of replication initiation systems regulated through the proteins-interacting domain of DnaA

2008 - 2010 Interaction analysis of chromosomal replication related proteins in Escherichia coli.

2005 - 2009 Analysis on regulatory factors and functional mechanisms for the initiator protein of the chromosomal replication

2007 - 2008 High-order Structure-based Molecular Mechanisms in Replicational Initiation Complex Formation, DNA Unwinding, and Dissociation

2006 - 2007 Functional analysis based on the structure of DNA replication proteins in Escherichia coli

2006 - 2007 Development of novel spin-labeled nucleic acids for detection of DNA internal dynamics

2006 - 2007 核酸のインターナルダイナミクスを鋭敏に捕えるスピンラベル化核酸の開発と応用

2006 - 2007 開始のオン・オフにより周期的に複製を行う大腸菌ミニ染色体複製サイクルの再構成

2004 - 2006 Protein Dynamics in Complex Apparatus for the Initiation and Regulation of the Chromosomal Replication

2001 - 2004 Genetic Analyses on the functional network of essential genes in Escherichia cali

2002 - 2003 STRUCTURE AND FUNCTION OF MOLECULRAR SWITCH FOR CHROMOSOMAL REPLICATION

2001 - 2003 STUDY ON RATIONAL DEVELOPMENT OF NOVEL ANTIBIOTICS TAGRETING DnaA DOMAIN IV

1999 - 2003 複製開始と細胞周期を制御する染色体複製装置の構造と機能

2000 - 2001 REGULATORY MACHINERY FOR THE E. COLI CHROMOSOMAL REPLICATION CYCLE

2000 - 2000 大腸菌必須遺伝子群の機能ネットワークの遺伝学的解析

1998 - 1999 Interaction between the replicational initiator DnaA and the DNA polymerase components

1996 - 1999 Regulation of initiation of chromosome replication

1997 - 1997 染色体の複製開始の頻度と同時性の制御装置

1996 - 1997 Study on molecular structure-function relationship of E..coli DnaA protein

1996 - 1996 DNA高次構造構築に関与する大腸菌遺伝子の検索

1996 - 1996 大腸菌DnaAタンパク質機能の制御装置の分子機構

1995 - 1995 大腸菌染色体複製の開始制御の分子機構:開始因子DnaAタンパク質の機能制御機構

DNA複製を阻害する抗菌剤

DNA複製をモニターするチェックポイント制御機構

大腸菌染色体DNAの複製制御機構

Autibiotics that inhibit DNA replication

Mechanism for the check-point regulation that monitors DNA replication

Molecular Mechanism for control of the E.coli chromosomal replication

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Papers (112)：

Yusuke Akama, Ryusei Yoshida, Shogo Ozaki, Hironori Kawakami, Tsutomu Katayama. SSB promotes DnaB helicase passage through DnaA complexes at the replication origin oriC for bidirectional replication. Journal of biochemistry. 2025
Kazutoshi Kasho, Ryuji Sakai, Kosuke Ito, Wataru Nakagaki, Rion Satomura, Takafumi Jinnouchi, Shogo Ozaki, Tsutomu Katayama. Read-through transcription of tRNA underlies the cell cycle-dependent dissociation of IHF from the DnaA-inactivating sequence datA. Frontiers in microbiology. 2024. 15. 1360108-1360108
Kazutoshi Kasho, Shogo Ozaki, Tsutomu Katayama. IHF and Fis as Escherichia coli Cell Cycle Regulators: Activation of the Replication Origin oriC and the Regulatory Cycle of the DnaA Initiator. International journal of molecular sciences. 2023. 24. 14
Chuyuan Lu, Ryusei Yoshida, Tsutomu Katayama, Shogo Ozaki. Thermotoga maritima oriC involves a DNA unwinding element with distinct modules and a DnaA-oligomerizing region with a novel directional binding mode. The Journal of biological chemistry. 2023. 104888-104888
Ryusei Yoshida, Shogo Ozaki, Hironori Kawakami, Tsutomu Katayama. Single-stranded DNA recruitment mechanism in replication origin unwinding by DnaA initiator protein and HU, an evolutionary ubiquitous nucleoid protein. Nucleic acids research. 2023

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MISC (12)：

片山勉, 吉田竜星, 川上広宣, 加生和寿, 尾崎省吾. 核様体タンパク質から複製開始メカニズムの共通原理を展望する. 日本ゲノム微生物学会ニュースレター. 2023. No.28
川上広宣, 片山勉. 真核細胞ゲノムにおける複製起点探しの分子機構. 九州大学アイソトープ総合安全管理センターニュース. 2018. 3. 7-8
片山勉, 尾崎省吾, 尾崎省吾, 松田雄作, 松田雄作, 毛谷村賢司, 毛谷村賢司, 川上広宣, 野口泰徳, 加生和寿, et al. 大腸菌染色体DNAの接着と分配に必要な新規DNA-蛋白質複合体. 日本細菌学雑誌. 2014. 69. 1
片山勉. 複製後のDNAの接着と分配を制御する新規なタンパク質因子. ファルマシア, 51(2):99-103. 2014
片山勉. 高次制御機構を備えた新たなゲノム複製系の再構成に向かって. 実験医学「細胞を創る・生命システムを創る」. 2011. 29. 7. 83-89

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Works (2)：

DNA複製阻害剤スクリーニング系の開発
1999 -
Development of systems screening novel inhibitors for DNA replication
1999 -

Education (4)：

1985 - 1990 京都大学大学院理学研究科生物物理学
- 1990 Kyoto University Graduate School, Division of Natural Science
1980 - 1985 Nagoya University School of Science
- 1985 Nagoya University Faculty of Science

Professional career (1)：

Ph.D. (Kyoto University)

Work history (15)：

2002 - 現在 Kyushu University Faculty of Pharmaceutical Sciences
2001 - 2002 Kyushu University Faculty of Pharmaceutical Sciences
2001 - 2002 Kyushu University Graduate School of
2002 - - Kyushu University Graduate School of
1994 - 2001 Kyushu University Faculty of Pharmaceutical Sciences

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Committee career (6)：

- 現在日本学術会議連携会員
- 現在日本生化学会評議員
- 現在日本生化学会代議員
- 現在日本遺伝学会評議員
日本ゲノム微生物学会評議員

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Awards (3)：

2017 - 日本遺伝学会木原賞
2009 - Asia-Pacific International Molecular Biology Network: Arthur Kornberg Memorial Lecture Award
2001 - 九州大学総長賞(若手研究者奨励)

Association Membership(s) (5)：

日本ゲノム微生物学会 , 日本遺伝学会 , 日本薬学会 , 日本生化学会 , 日本分子生物学会

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