- 2024 - 2028 骨髄由来間葉系幹細胞を起点とした新たな口腔癌転移メカニズムの解明
- 2023 - 2027 Selective induction of bone and cartilage differentiation and reconstruction of the mandibular condyle using miRNA and TCP hybrid biomaterials
- 2023 - 2027 癌骨破壊病変において新規破骨細胞形成促進因子Angiogeninが果たす役割の解明
- 2023 - 2026 骨髄由来間葉系幹細胞を用いた新規骨折治癒促進治療の開発
- 2023 - 2026 Development of a novel treatment for ameloblastoma by modifying tumor stroma based on CCN2
- 2022 - 2026 Molecular Basis of Hedgehog Signaling and New Therapeutic Strategies for Cancer induced Bone-Destruction
- 2020 - 2025 口腔扁平上皮癌における新規遠隔転移抑制治療の開発
- 2022 - 2025 口腔癌間質が主導する実質進展制御メカニズム解明と新規治療法開発
- 2021 - 2025 細胞競合による癌の生物学的性格および癌化の制御
- 2020 - 2024 エナメル上皮腫の生物学的性格制御による腫瘍実質ー間質相互作用破綻の誘導
- 2020 - 2023 Development of anti-tumor drugs targeting CD81
- 2020 - 2023 miRNAが支配する骨・軟骨分化方向決定メカニズムの解明
- 2019 - 2022 口腔癌分泌エクソソームを用いた分子標的抗癌剤感受性試験の開発
- 2018 - 2022 The study of the regulatory mechanisms of cancer bone destruction metabolism and immunity in Hedgehog signaling
- 2018 - 2021 Regulation of the biological character of cancer and induction of cancer by the cancer stroma.
- 2017 - 2021 Involvement and function elucidation of stromal cells in the process of bone invasion of odontogenic tumors
- 2017 - 2020 Development of novel gene therapy for rheumatoid arthritis
- 2017 - 2020 Differentiation mechanism of cell proliferation, migration, adn differntiation in the oral proliferative lesions
- 2016 - 2019 Characterization and potential roles of bone marrow-derived stromal cells in premetastasis niche
- 2014 - 2018 Characterization and potential roles of bone marrow-derived stromal cells in cancer development and metastasis
- 2014 - 2017 Development of new therapies targeting SHH in oral cancer jaw bone destruction and its application to personalized medicine
- 2014 - 2017 Large-scale collaborative research on actual condition of odontogenic tumor in Asia
- 2014 - 2017 Development of novel therapeutic compounds for rheumatoid arthritis targeting CD81
- 2014 - 2017 A new reconstruction method using intraosseous microenvironment reproduction system of segmental excision bone
- 2014 - 2017 Elucidation of the molecular mechanisms of the periodontal tissue repair
- 2013 - 2016 Development of novel treatment and functional analysis of molecular regulation of Sjogren's syndrome by using mesenchymal stem cells
- 2012 - 2016 Alveolar bone regeneration based on the low invasive therapy using in vivo BMP gene transfer.
- 2012 - 2016 Functional analysis of candidate tumor suppressor gene, RIZ in oral squamous cell carcinoma.
- 2012 - 2015 Molecular imaging analysis of the antitumour activity of 5-fluorouracil combine with Mycobacterium bovis bacillus Calmette-Guérin (BCG) in the mouse oral cancer model.
- 2012 - 2015 Mimic periodontal tissue by using in vitro dentin
- 2010 - 2014 Differentiation induction of mesenchymal stem cells in the peripheral blood into tooth structure forming cells
- 2011 - 2014 象牙質シートを用いた生体機能付加インプラントシステムの開発
- 2011 - 2013 Development of novel antibody therapy targeting tetraspanin CD81
- 2011 - 2013 Development of a new tooth coating with antibacterial property by using new biomaterial of Calcium Titanate
- 2010 - 2012 Development of a highly sensitive genetic diagnosis ofSjogren syndrome based on detection ofβdefensins
- 2010 - 2011 頭頸部扁平上皮癌における新規癌抑制遺伝子の機能解析
- 2009 - 2011 エナメル上皮腫における骨形成抑制メカニズムの解明
- 2009 - 2011 Functional analysis of candidate tumor suppressor gene, ING family in head and neck squamous cell carcinoma.
- 2008 - 2010 Three-dimensional analysis of dental titanium implant coated by a new biomaterial
- 2008 - 2010 Molecular mechanism of cyto-differentiation of proliferating bone resorping lesions
- 2008 - 2010 Development of a new tooth coating with anti-carious and anti-periodontitis properties by using nanoparticles of Calcium Titanate
- 2008 - 2009 Differentiation induction of bone marrow stem cells into tooth component cells
- 2007 - 2009 Basic research of a novel dental material : Calcium Titanium Oxide-Amorphous Carbon for applying the lining material
- 2007 - 2008 金属医用材料新規コーティング材チタン酸カルシウム非晶質炭素複合物の組織反応
- 2007 - 2008 Loss of heterozygosity analysis and its relationship with Clinicopathological features in ameloblastoma
- 2005 - 2008 Research Technological Study of Tumor Gene Analysis in Oral Cancer and Odontogenic Tumor for Asian People.
- 2005 - 2006 Role of heparanase in odontogenic tumors
- 2005 - 2006 Functional Analysis of Tumor Suppressor ING Family in Oral Cancer
- 2003 - 2006 Molecular biological analysis of tooth germ and odontogenic tumor
- 2003 - 2004 Analysis of Cancer Gene Polymorphism Using Gigabit Internet
- 2000 - 2002 Molecular pathological study of tooth germ and odonto genic tumor
- 1999 - 2001 Gene expression of BMP family and receptors during tooth development
- 1997 - 1999 The Analysis of Gene Expression of Morphogenetic Factors Implicated Development of Tooth Germ and Odontogenic Tumors
- 1998 - 1998 上皮・間葉相互作用-特に歯胚分化-に関与するBMP-3の作用について
- 1996 - 1996 歯胚発生過程における骨誘導蛋白質(BMP)-2,4,7遺伝子の局在変化と定量解析
- 1995 - 1996 Ditribution of bone matrix proteins and PTH recepter mRNA during ectopic bone formation induced by BMP
- 1995 - 1995 骨誘導蛋白-コラーゲン被覆チャンバーによる異所性骨誘導の細胞分化の解析
- 1994 - 1995 Gene Expression and Development of Odontogenic tumors
- 1994 - 1994 異所性骨形成における骨基質蛋白の局在と遺伝子の発現
- 1992 - 1992 合成アパタイト・骨誘導物質複合体による異所性骨髄形成を有する人工骨の開発
- 1992 - 1992 歯原性腫よう上皮と嚢胞上皮との鑑別に関する免疫組織化学的研究
- 1991 - 1992 Immunohistochemical Analysis of Odontogenic and Osteogenic Tumors
- 1991 - 1992 Expression of Cytokeratins in Odontogenic Tumors.
- Distribution of bone matrix Pratein mRNA during heterotopic bone formation induced by BMP
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